A5026234677- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Dental Research and COVID-19
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Long-Term Effects of COVID-19
- Antifungal resistance and susceptibility
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Plant and Fungal Interactions Research
- Skin Protection and Aging
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Health disparities and outcomes
- COVID-19 Clinical Research Studies
- Fungal and yeast genetics research
- Acne and Rosacea Treatments and Effects
- Yeasts and Rust Fungi Studies
- Mycobacterium research and diagnosis
- Molecular Biology Techniques and Applications
- COVID-19 and Mental Health
- Thermal Regulation in Medicine
- Dental Health and Care Utilization
- melanin and skin pigmentation
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2022-2025
Centre for Genomic Regulation
2008-2022
Universitat Politècnica de Catalunya
2020-2022
Barcelona Supercomputing Center
2020-2022
Institute for Research in Biomedicine
2020-2022
Universitat Pompeu Fabra
2011-2019
Barcelona Institute for Science and Technology
2017
Institut d'Investigacions Biomèdiques de Barcelona
2008-2009
Consejo Superior de Investigaciones Científicas
2008-2009
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2008-2009
MicroRNAs (miRNAs) are post-transcriptional gene expression regulators, playing key roles in neuronal development, plasticity and disease. Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by presence of protein inclusions or Lewy bodies a progressive loss dopaminergic neurons midbrain. Here, we have evaluated miRNA deregulation PD brain samples. MiRNA profiling revealed decreased miR-34b miR-34c areas with variable neuropathological affectation at...
The oral cavity comprises a rich and diverse microbiome, which plays important roles in health disease. Previous studies have mostly focused on adult populations or very young children, whereas the adolescent microbiome remains poorly studied. Here, we used citizen science approach 16S profiling to assess of 1500 adolescents around Spain its relationships with lifestyle, diet, hygiene, socioeconomic environmental parameters.Our results provide detailed snapshot how it varies lifestyle other...
Candida glabrata is an opportunistic fungal pathogen that ranks as the second most common cause of systemic candidiasis. Despite its genus name, this yeast more closely related to model Saccharomyces cerevisiae than other pathogens, and hence ability infect humans thought have emerged independently. Moreover, C. has all necessary genes undergo a sexual cycle but considered asexual organism due lack direct evidence reproduction. To reconstruct recent evolution find footprints reproduction, we...
The relevance of the human oral microbiome to our understanding health has grown in recent years as studies continue develop. Given links cavity with digestive, respiratory and circulatory systems, composition is relevant beyond just health, impacting systemic processes across body. However, we still have a very limited about intrinsic extrinsic factors that shape healthy microbiome. Here, followed citizen-science approach assess relative impact on selected biological, social, lifestyle 1648...
Human pigmentation has largely been associated with different disease prevalence among populations, but most of these studies are observational and inconclusive. Known to be genetically determined, pigmentary traits have studied by Genome-Wide Association Study (GWAS), mostly in Caucasian ancestry cohorts from North Europe, identifying robustly, several loci involved many the traits. Here, we conduct a detailed analysis GWAS Polygenic Risk Score (PRS) 13 pigmentary-related South European...
Long-COVID has mostly been investigated in clinical settings. We aimed to assess the risk, subtypes, persistence, and determinants of long-COVID a prospective population-based study adults with history SARS-CoV-2 infection Catalonia. examined 2764 infected individuals from cohort (COVICAT) established before pandemic followed up three times across (2020, 2021, 2023). assessed immunoglobulin (Ig)G levels against SARS-CoV-2, clinical, vaccination, sociodemographic, lifestyle factors. risk...
Abstract Lingo‐1 (also known as Lern1) is a component of the Nogo receptor complex that mediates intracellular signaling in response to myelin associated inhibitors (MAIs): NogoA, MAG, and Omgp. Signaling through extends more than its well role preventing axon regeneration after lesion CNS, being implicated neuronal functional maturation. Using Lingo‐1‐deficient mice, it has been demonstrated plays relevant roles oligodendrocyte differentiation during brain development, treatment with...
Introduction: The oral cavity harbors an abundant and diverse microbial community (i.e. the microbiome), whose composition roles in health disease have been focus of intense research. Down syndrome (DS) is associated with particular characteristics cavity, a lower incidence caries higher periodontitis gingivitis compared to control populations. However, overall microbiome DS how it varies factors like host age or pH within mouth are still poorly understood. Methods: Using Citizen-Science...
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 COVID-19 cases 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 present 2.4% young (<60 years) no reported clinical (n = 378), compared 0.24% (odds ratio [OR] 12.3, p 1.27 × 10
<title>Abstract</title> Population-based cohorts play a key role in personalized medicine. However, it is known that are affected by the "healthy volunteer bias" where participants generally healthier than broader population, compromising its representativeness. Here, we assess healthy bias, identifying bias indicators for representativeness of GCAT cohort, encompassing 20 000 adult Catalonia, and generating survey raked weights to enhance cohort’s comparability. To correct compare multiple...
Long non-coding RNAs (lncRNAs) are a heterogeneous class of genes that do not code for proteins. Since lncRNAs (or fraction thereof) expected to be functional, many efforts have been dedicated catalog in numerous organisms, but our knowledge non vertebrate species remains very limited. Here, we annotated using transcriptomic data from the same larval stage four Caenorhabditis species. The number self-fertile nematodes was lower than out-crossing We used combination approaches identify...
Abstract Background Epidermal Growth Factor (EGF) is a key regulatory growth factor activating many processes relevant to normal development and disease, affecting cell proliferation survival. Here we use combined approach study the EGF dependent transcriptome of HeLa cells by using multiple long oligonucleotide based microarray platforms (from Agilent, Operon, Illumina) in combination with digital gene expression profiling (DGE) Illumina Genome Analyzer. Results By applying procedure for...
Introduction: Cystic fibrosis (CF) is an autosomal genetic disease, associated with the production of excessively thick mucosa and life-threatening chronic lung infections. The microbiota oral cavity can act as a reservoir or barrier for infectious microorganisms that colonize lungs. However, specific composition microbiome in CF poorly understood.Methods: In collaboration associations Spain, we collected rinse samples from 31 persons (age range 7-47) matched controls, then performed 16S...
Limited research suggests that certain viruses reactivate in severe-acute-respiratory-syndrome-coronavirus 2 infection, contributing to the development of postacute sequelae COVID-19 (PASC). We examined 1083 infected individuals from a population-based cohort, and assessed differences plasma immunoglobulin (Ig)G A levels against Epstein-Barr virus (EBV), cytomegalovirus, varicella zoster (VZV), BK polyomavirus, KI WU polyomavirus (WUPyV), respiratory syncytial virus, Adv-36 according...
Long non-coding RNAs (lncRNAs) play important roles in cancer and are potential new biomarkers or targets for therapy. However, given the low tissue-specific expression of lncRNAs, linking these molecules to particular types processes through transcriptional profiling is challenging. Formalin-fixed, paraffin-embedded (FFPE) tissues abundant resources research but prone nucleic acid degradation, thereby complicating study lncRNAs. Here, we designed validated a probe-based enrichment strategy...
Abstract Background Population-based cohorts play a key role in epidemiological studies. However, it is known that volunteer include healthy bias. Assessment and characterization of this bias needed to extrapolate results the general population. Here, we assess population-based cohort GCAT, encompassing 20 000 adult participants from Catalonia with electronic health record data. The aim study compare GCAT its age-matching Catalan population, their representativeness, as well determining...