A5067385960- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Family Support in Illness
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Pharmacological Effects and Toxicity Studies
- Monoclonal and Polyclonal Antibodies Research
- Electrolyte and hormonal disorders
- Extracellular vesicles in disease
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Genital Health and Disease
- Advanced Breast Cancer Therapies
- Simulation-Based Education in Healthcare
- Numerical methods in inverse problems
- Cancer-related cognitive impairment studies
- Advanced Mathematical Modeling in Engineering
- Potassium and Related Disorders
- Ovarian cancer diagnosis and treatment
Universitätsklinikum Würzburg
2019-2024
Universitäts Frauenklinik
2020-2024
Kantonsspital St. Gallen
2024
University of Würzburg
2021-2023
Imperial College London
2022
Universitäts-Kinderklinik Würzburg
2021
University of Stuttgart
2020
Lawson Health Research Institute
1998
Brain metastases are the most severe tumorous spread during breast cancer disease. They associated with a limited quality of life and very poor overall survival. A subtype extracellular vesicles, exosomes, sequestered by all kinds cells, including tumor play role in cell-cell communication. Exosomes contain, among others, microRNAs (miRs). can be taken up other cells body, their active molecules affect cellular process target cells. Tumor-secreted exosomes integrity blood-brain barrier (BBB)...
Computational prediction of limiting activity coefficients is great relevance for process design. For highly nonideal mixtures including molecules with directed interactions, methods that maintain the molecular character solvent are most promising. expense and force-field deficiencies main factors prevent use high-throughput dynamics (MD) simulations in a predictive setup. The combination MD machine learning used this work accounts both issues. Comparison to published data free-energy...
Abstract Background Cervical cancer often originates from cervical cell dysplasia. Previous studies mainly focused on surgical margins and high-risk human papillomavirus persistence as factors predicting recurrence. New research highlights the significance of positive findings endocervical curettage (ECC) during excision treatment. However, combined influence margin ECC status dysplasia recurrence risk has not been investigated. Methods In this retrospective study, data 404 women with...
Background and Objectives:Skills-lab training is crucial for the development of advanced laparoscopic skills. In this study, we examined whether a systematic deconstructive comprehensive tutoring approach improves results in suturing intracorporeal knot tying.Methods:Sixteen residents obstetrics gynecology participating structured skills-lab laparoscopy were randomized 2 equal-sized groups receiving 1-on-1 either traditional method or according to Peyton's 4-step approach, involving an...
Therapeutic options for breast cancer (BC) treatment are constantly evolving. The Human Epidermal Growth Factor 2 (HER2)-low BC entity is a new subgroup, representing about 55% of all patients. New antibody-drug conjugates demonstrated promising results this subgroup. Currently, there limited information the conversion HER2 subtypes between primary tumor and recurrent disease.This retrospective study included women with at University Medical Centre Wuerzburg from 1998 to 2021. Data were...
Abstract Purpose Definitive fascial closure is an essential treatment objective after open abdomen and mitigates morbidity mortality. There a paucity of evidence on factors that promote or prevent definitive closure. Methods A multi-center multivariable analysis data from the Open Abdomen Route European Hernia Society included all cases between 1 May 2015 31 December 2019. Different elements, i.e. use visceral protective layer, negative-pressure wound therapy dynamic techniques, as well...
Pelvic palpation is a core component of every Gynecologic examination. It requires vigorous training, which difficult due to its intimate nature, leading need simulation. Up until now, there are mainly models available for mere do not offer adequate visualization the concerning anatomical structures. In this study we present 3D printed model female pelvis. can improve both practical teaching gynecological pelvic examination health care professionals and spatial understanding relevant...
Abstract Purpose: This study aims to investigate the psychological distress experienced by patients with initial diagnosis of abnormal Pap smears or dysplastic changes cervix uteri. It is investigated whether patients' age, education, information level and approach acquisition have an impact on their distress. Methods: A total 364 female patients, aged 20-80 years, referred special dysplasia consultation hour at Department Obstetrics Gynecology, Wuerzburg, completed a questionnaire...
Abstract Background 3D printing holds great potential of improving examination, diagnosis and treatment planning as well interprofessional communication in the field gynecological oncology. In current manuscript we evaluated five individualized, patient-specific models cervical cancer FIGO Stage I-III, created with printing, concerning their value for translational Methods Magnetic resonance imaging (MRI) pelvis was performed on a 3.0 Tesla MRI, including T2-weighted isotropic sequence. The...
Abstract Purpose The reliable detection of tumor-infiltrated axillary lymph nodes for breast cancer [BC] patients plays a decisive role in further therapy. We aimed to find out whether cross-sectional imaging techniques could improve sensitivity pretherapeutic staging nodal-positive BC compared conventional such as mammography and sonography. Methods Data with having received surgery between 2014 2020 were included this study. All examinations (sonography, mammography, computed tomography...
Due to improved therapy, early diagnosis, and growing incidence rates, the number of long-term breast cancer survivors is increasing. Survivors can still be affected by aftercare, resulting in reduced quality life (QoL). Thus, this study, we investigated possible predictors decreased physical social functioning survivors.In a German multicenter prospective enrolled 759 female patients with before surgery (t1), contacted them again 5 years after (t4). Data on QoL were assessed at t4 using...
Cluster approaches to local economic development. Theoretical considerations and case studies from Wolfsburg Hannover. Since the 1990s. cluster have become highly fashionable among scholars in geography regional economics, policy-makers alike. This paper explores theoretical foundations of concept, which eclectically draws on various schools thought. Clusters can be either conducive or harmful depending a set framework conditions life cycle. A number preconditions derived that will...
Background Genital human papillomavirus (HPV)-infections are common in the general population and responsible for relevant numbers of epithelial malignancies. Much data on HPV-prevalence is available secondary immunodeficiencies, especially patients with immunodeficiency virus (HIV)-infection. Little known about genital primary immunodeficiencies (PIDs). Methods We performed a cross-sectional study PIDs took swabs from male female patients, which were analyzed polymerase chain reaction...
Simulation in the field of gynecological pelvic examination with educational purposes holds great potential. In current manuscript we evaluate a 3D printed model female pelvis, which improves practical teaching for medical staff.We evaluated benefit pelvis (Pelvisio®) as part seminar ("skills training") to students. Each student was randomly assigned Group A or B by picking ticket from box. underwent skills training without model. experienced same integration Both groups answering five...
Abstract Purpose An increasing incidence of breast cancer can be observed worldwide. Since a delay therapy have negative impact on prognosis, timely care is an important quality indicator. By receiving treatment at certified center, the patient has best chance in accordance with guidelines and prognosis. The identification risk factors for central importance should basis continuous optimization centers. Methods This retrospective study included women (primary diagnosis, relapse, or secondary...
Abstract Purpose Electrosurgery is the gold-standard procedure for treatment of cervical dysplasia. The quality outcome depends on accuracy performance, which underlines role adequate training surgeons, especially, as this often performed by novice surgeons. According to our knowledge, medical simulation has up until now lacked a model, focuses realistically simulating dysplasia with concerning anatomy. Methods and result In work, we present model created using 3D printing holistically...
Objective: We aimed to evaluate real-world data for the use of fractional CO2 laser therapy treating symptoms vulvovaginal atrophy (VVA). Background: VVA is widespread and can reduce patients' quality life. There a lack regarding its with laser, especially daily practice (i.e., data). Methods: Thirty-six patients were treated in single medical center. They consisted pre- postmenopausal women received three treatments 3-6 weeks between each treatment. Each patient financed treatment...
This study investigated whether virtual monoenergetic images (VMIs) and iodine mapping based on dual-energy CT (DECT) provide advantages in the assessment of endometrial cancer. A dual-source DECT was performed for primary staging histologically proven endometrioid adenocarcinoma 21 women (66.8 ± 12.0 years). In addition to maps, VMIs at 40, 50, 60, 70, 80 keV were reconstructed from polyenergetic (PEIs). Objective analysis comprised measurement tumor contrast, contrast-to-noise ratio,...
Abstract Purpose Isolated locoregional recurrence of breast cancer (ILRR) and contralateral (CBC) affect up to 20% all (BC) patients in the first 20 years after primary diagnosis. Treatment options comprise surgical interventions further systemic therapies depending on histological subtype. Patients with hereditary or ovarian (HBOC) undergo MRI, mammography, ultrasound aftercare BC, while non-HBOC (nHBOC) do not regularly receive MRI. Since early detection is crucial for morbidity mortality,...
<title>Abstract</title> Background Cervical cancer often originates from cervical cell dysplasia. Previous studies mainly focused on surgical margins and high-risk human papillomavirus persistence as factors predicting recurrence. New research highlights the significance of positive findings endocervical curettage (ECC) during excision treatment. However, combined influence margin ECC status dysplasia recurrence risk has not been investigated. Methods In this retrospective study, data 404...