Frank W. Brennfleck

ORCID: 0000-0001-8055-9282
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About
Contact & Profiles
Research Areas
  • Abdominal Surgery and Complications
  • Liver Disease and Transplantation
  • Organ Transplantation Techniques and Outcomes
  • Liver Disease Diagnosis and Treatment
  • Surgical site infection prevention
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Renal Transplantation Outcomes and Treatments
  • Hernia repair and management
  • Pelvic and Acetabular Injuries
  • Surgical Sutures and Adhesives
  • Pneumothorax, Barotrauma, Emphysema
  • Pancreatic and Hepatic Oncology Research
  • Clinical Nutrition and Gastroenterology
  • Organ Donation and Transplantation
  • Cardiac, Anesthesia and Surgical Outcomes
  • Gallbladder and Bile Duct Disorders
  • Muscle and Compartmental Disorders
  • MRI in cancer diagnosis
  • COVID-19 and healthcare impacts
  • Congenital Anomalies and Fetal Surgery
  • Diagnosis and Treatment of Venous Diseases
  • Hip and Femur Fractures
  • Body Contouring and Surgery
  • Intramuscular injections and effects
  • Transplantation: Methods and Outcomes

Gollwitzer-Meier-Klinik
2023-2025

Helios Vogtland Klinikum Plauen
2024

University Hospital Regensburg
2018-2023

Background: Critically ill patients requiring extracorporeal membrane oxygenation (ECMO) have several risk factors to suffer from abdominal compartment syndrome (ACS). Little is known about this subgroup. The aim of study was investigate the prevalence and associated for ACS in ECMO assess effect decompressive laparotomy (DL) impact on mortality. Methods: This retrospective observational analyzed adult four intensive care units at University Medical Center Regensburg between 01/2010 06/2020....

10.3390/jcm14030855 article EN Journal of Clinical Medicine 2025-01-28

Objective To evaluate the influence of an active inflammatory process in liver on Gd-EOB-DTPA-enhanced MR imaging patients with different degrees fibrosis/cirrhosis. Material and methods Overall, a number 91 (61 men 30 women; mean age 58 years) were included this retrospective study. The inclusion criteria for study MRI histopathological evaluation fibrotic changes. T1-weighted VIBE sequences fat suppression evaluated to determine relative signal change (RE) between native hepatobiliary...

10.1371/journal.pone.0215752 article EN cc-by PLoS ONE 2019-05-13

Abstract Purpose Definitive fascial closure is an essential treatment objective after open abdomen and mitigates morbidity mortality. There a paucity of evidence on factors that promote or prevent definitive closure. Methods A multi-center multivariable analysis data from the Open Abdomen Route European Hernia Society included all cases between 1 May 2015 31 December 2019. Different elements, i.e. use visceral protective layer, negative-pressure wound therapy dynamic techniques, as well...

10.1007/s10029-020-02336-x article EN cc-by Hernia 2020-11-21

Abstract Background Pediatric liver transplantations generally represent advanced surgery for selected patients. In case of acute or chronic graft failure, biliary vessel complications, a retransplantation (reLT) can be necessary. these situations massive adhesions, critical patient condition lack good vessels anastomosis often are problematic. Methods Between 2008 and 2021, 208 pediatric patients received transplantation at our center. Retrospectively, all cases with least one were...

10.1111/petr.14699 article EN cc-by-nc-nd Pediatric Transplantation 2024-03-01

Abstract Strong correlations between the grade of fibrosis and cirrhosis, classified using Ishak scoring system, uptake characteristics Gd-EOB-DTPA with relative enhancement (RE) liver parenchyma have been reported. To confirm results a retrospective analysis, patients undergoing surgery were prospectively examined Gd-EOB-DTPA-enhanced 3 Tesla MRI to determine degree fibrosis. Correlations RE investigated compared those derived from an initial study. After validating cut-off values in study...

10.1038/s41598-018-24316-z article EN cc-by Scientific Reports 2018-04-12

Abstract Surgical site infections (SSI) in open Hepatopancreatobiliary (HPB) surgery are common complications. They worsen patients’ outcomes and prolong hospital stays. Their economic significance the German diagnosis related groups (DRG) system is mostly unknown. To investigate their importance, we evaluated all cases for SSIs as well clinical financial parameters undergoing our centre from 2015 2016. Subsequently, carried out a cost‐revenue calculation by assessing billing data cost...

10.1111/iwj.13511 article EN cc-by-nc International Wound Journal 2020-10-02

Abstract Background Risks for living-liver donors are lower in case of a left liver donation, however, due to graft volume, the risk small-for-size situations recipients increases. This study aims prevent using an auxiliary two-staged partial resection transplantation (LTX) living-donated lobes. Case presentation Two patients received two-stage LTX lobes after lateral resection. The native extended right was removed second operation sufficient hypertrophy had occurred. Neither donor...

10.1186/s12893-021-01167-6 article EN cc-by BMC Surgery 2021-03-26

Abstract This study aimed to assess the degree of differentiation hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1 relaxometry. Thirty-three solitary HCC lesions were included in this retrospective study. study's inclusion criteria preoperative MRI liver and a histopathological evaluation after hepatic tumor resection. maps evaluated determine relaxation time reduction rate between native phase hepatobiliary (HBP) lesions. These findings...

10.1038/s41598-021-02499-2 article EN cc-by Scientific Reports 2021-11-26

Abstract Background Graft rejection and chronic CNI toxicity remain obstacles to organ transplant success. Current formulations of tacrolimus, such as Prograf® Advagraf™, exhibit limitations in terms pharmacokinetics tolerability, related part suboptimal bioavailability. As dosing non-compliance can result graft rejection, the once daily formulation was developed (vs 2x/day Prograf®). Benefits Advagraf™ are counterbalanced by delayed achievement therapeutic trough levels need for up 50%...

10.1186/s13063-023-07344-7 article EN cc-by Trials 2023-05-11

Abstract Development of subcutaneous abdominal wound healing impairment (SAWHI) can greatly affect patient care. Complications from SAWHI include delayed healing, increased risk infection, and fascial dehiscence resulting in care associated costs. Treatment options conventional treatment or negative pressure therapy, both which be used the out‐of‐hospital setting. However, limited published evidence on cost‐effectiveness exists. A conservative health economic model was created to assess...

10.1111/iwj.13894 article EN International Wound Journal 2022-07-14

Abstract Background Incisional surgical site infections (iSSI) in hepatopancreatobiliary (HPB) surgery usually lead to prolonged hospital stays, consume valuable resources, and impact on patients’ outcome. Prophylactic closed incision negative pressure wound therapy (ciNPWT) decrease complications has become available. Owing an increasing number of studies, evidence for superiority many indication areas accumulated; however, general surgery, there are a few data those have shown...

10.1186/s13063-020-04831-z article EN cc-by Trials 2020-11-09

Abstract In case of potential contamination, implantation synthetic meshes in hernia and abdominal wall surgery is problematic due to a higher risk mesh infection. As an alternative, variety different biologic have been used. However, relevant data comparing outcome after these are lacking. Between January 2012 October 2021, were used for reconstruction the 71 patients with preoperative or intraoperative contamination. this retrospective study, semiresorbable hybrid (BHM) completely...

10.1007/s13304-022-01378-3 article EN cc-by Updates in Surgery 2022-10-12

The ongoing SARS-COV-2 pandemic has severe implications for people and healthcare systems everywhere. In Germany, worry about the consequences of led to deferral non-emergency surgeries. Tumor surgery accounts a large volume in field visceral cannot be considered purely elective. It is not known how changed surgical tumor patients.Retrospective analysis amount oncological surgeries three academic departments Bavaria, 2020. Procedures were split into subgroups: Upper Gastrointestinal (Upper...

10.1186/s12893-021-01404-y article EN cc-by BMC Surgery 2021-12-01

Living donor liver transplantation (LDLT) from hepatitis C virus (HCV)–positive donors into HCV-positive recipients is not established yet.(1) We report a case of combining direct antiviral agent (DAA) therapy and living donation with chronic HCV infection (genotype 3a) to recipient congenital 3a). The recipient, an 11-year-old female (body mass index [BMI] = 20.1 kg/m2), underwent subtotal left pancreas resection splenectomy partial omentectomy due pseudopapillary tumor (PPT) in 2015....

10.1002/hep.31185 article EN cc-by-nc Hepatology 2020-02-17

Abstract Background After pediatric split liver transplantation, intra‐abdominal loss of domain due to large‐for‐size left lateral grafts is a frequent problem for fascial closure and potentially leads reduced perfusion abdominal compartment syndrome. Therefore, delayed with the use temporary silastic meshes reoperation or alternative bridging procedures are necessary. Methods Between March 2019 October 2021, biologic were used wall expansion in 6 cases transplantation. These analyzed...

10.1111/petr.14405 article EN Pediatric Transplantation 2022-10-06

Early patient and allograft survival after liver transplantation (LT) depend primarily on parenchymal function, but long-term success relies often biliary-tree function. We examined parameters related to cholangiocyte damage that predict poor LT outcomes donation brain death (DBD).Sixty bile ducts (BD) were assessed by a BD damage-score divided into groups with "major" BD-damage (n = 33) "no relevant" 27) during static cold storage. Patients further investigated measuring biliary excretion...

10.1111/ctr.14880 article EN cc-by-nc Clinical Transplantation 2022-12-16

In the context of liver surgery, predicting postoperative dysfunction is essential. This study explored potential preoperative function assessment by MRI for and compared these results with established indocyanine green (ICG) clearance test. prospective included patients undergoing resection planning. Liver was quantified using T1 relaxometry correlated scores. The analysis revealed an improved model dysfunction, exhibiting accuracy (ACC) 0.79, surpassing 0.70 ICG test, alongside a higher...

10.3390/diagnostics13183014 article EN cc-by Diagnostics 2023-09-21

Ziel dieser Studie ist es den Einfluss eines aktiven Entzündungsprozess der Leber auf die Gd-EOB-DTPA-verstärkte MR-Bildgebung in Patienten mit unterschiedlichen Fibrose/Zirrhosegraden zu evaluieren.

10.1055/s-0037-1682113 article DE RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 2019-03-01

Fragestellung Die CT-Diagnostik stellt in Deutschland den Goldstandard der Polytraumadiagnostik dar und ist für Abdomenverletzungen im Rahmen des Polytraumas die primäre Phase unverzichtbar [1]. Verzögerte abdominelle Blutungen, primär nicht detektierbar sind oder sich erst sekundär manifestieren, können mit einer hohen Mortalität einhergehen [2,3]. S3-Leitlinien sehen eine standardmäßige Abdomen-Kontrollsonographie vor [4], Datenlage hierzu spärlich [5]. Ziel vorliegenden Studie es,...

10.1055/s-0040-1717340 article DE Zeitschrift für Orthopädie und Unfallchirurgie 2020-10-15

Background After pediatric split liver transplantation intraabdominal loss of domain due to a large-for-size left lateral graft is frequent problem for fascial closure and potentially leads reduced perfusion abdominal compartment syndrome. Therefore, delayed with use temporary silastic meshes reoperation or alternative bridging procedures are necessary.

10.1055/s-0041-1740719 article EN Zeitschrift für Gastroenterologie 2022-01-01
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