A5039356514- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic and Kidney Cyst Diseases
- Thyroid and Parathyroid Surgery
- Renal and Vascular Pathologies
- Gallbladder and Bile Duct Disorders
- Abdominal Surgery and Complications
- Pancreatic and Hepatic Oncology Research
- Thyroid Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Porphyrin Metabolism and Disorders
- Cancer Immunotherapy and Biomarkers
- Muscle and Compartmental Disorders
- Congenital Anomalies and Fetal Surgery
- Kidney Stones and Urolithiasis Treatments
- Glycogen Storage Diseases and Myoclonus
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
Martini-Klinik
2025
Karolinska University Hospital
2020
Karolinska Institutet
2020
Charité - Universitätsmedizin Berlin
2020
In-Q-Tel
2014
University Hospital of Bern
2008-2011
Phage therapy is an experimental therapeutic approach used to target multidrug-resistant bacterial infections. A lack of reliable data with regard its efficacy and regulatory hurdles hinders a broad application. Here we report, for the first time, case vancomycin-resistant Enterococcus faecium abdominal infection in one-year-old, critically ill, three times liver transplanted girl, which was successfully treated intravenous injections (twice per day 20 days) magistral preparation containing...
Anti-HLA antibodies and especially donor-specific (DSA) play a significant role in graft survival after solid organ transplantation. Their impact on long-term adult liver transplantation (LT) is controversial, but they may be risk factor. The effects of DSA pediatric LT are still unclear.We performed retrospective evaluation sera from 43 children who had received transplants at our tertiary center. Twenty-four patients good clinical laboratory function (group 1), whereas 19 recipients...
Recurrent attacks of acute intermittent porphyria (AIP) result in poor quality life and significant risks morbidity mortality. Liver transplantation (LT) offers a cure, but published data on outcomes after LT are limited. We assessed the pretransplant characteristics, complications, for patients with AIP who received transplant. Data were collected retrospectively from European Transplant Registry questionnaires sent to identified transplant centers. studied 38 transplants 12 countries 2002...
Liver transplantation (LT) has been shown to be a feasible treatment in patients with severe forms of maple syrup urine disease (MSUD). Because sufficient extrahepatic enzyme activity non ‐ MSUD individuals, the organ can used as domino graft. We performed retrospective data collection all LTs for carried out at University Medical Center Hamburg‐Eppendorf (2016‐2018). Moreover, from consecutive grafts either transplanted our institution or allocated other transplant centers were analyzed....
Introduction Combined or sequential liver and kidney transplantation (CLKT/SLKT) restores function corrects the underlying metabolic defect in children with end-stage disease primary hyperoxaluria type 1 (PH1). However, data on long-term outcome, especially infantile PH1, are rare. Methods All pediatric PH1-patients who underwent CLKT/SLKT at our center were analyzed retrospectively. Results Eighteen patients (infantile PH1 n = 10, juvenile 8) (CLKT 17, SLKT 1) a median age of 5.4 years...
Background. Studies reporting the immediate pediatric intensive care unit (PICU) treatment after combined liver-kidney transplantation (CLKT) are scarce, although this period is pivotal for survival and long-term outcome. Methods. We retrospectively analyzed all CLKT performed in our center between 1998 2010. Results. Sixteen patients underwent 17 at a median age of 5.3 years (range, 1.3–15.9 years). Median body weight was 17.7 kg 9.2–55 kg). Underlying diagnosis primary hyperoxaluria type 1...
Background. As long-term survival of pediatric liver transplant recipients increases, the assessment physical, psychological, and social well-being becomes more important. Methods. In this retrospective analysis, 120 young adult patients (age ≥18 y) who underwent transplantation in childhood were studied. Patients with ideal outcome defined as perfect graft function, no complications from immunosuppressive medication, late retransplantation, steroid treatment. Also, patients’ drug adherence...
We report on liver transplantation in two patients with GSD Ib treatment empagliflozin. The use of this SGLT2 inhibitor resulted a marked decrease 1,5-anhydroglucitol which has an important role the development neutropenia condition. As intended, caused significant rise neutrophil numbers. Liver alone did not produce desired effect and our observation argues for continuing after transplantation.
Immunosuppressed and immunocompromised patients are at high risk of infectious complications. Among those rare but sometimes lethal invasive fungal infections/disease (IFD). Especially immunosuppression caused by intense polychemotherapy, corticosteroids, prolonged, severe neutropenia or surrounding organ transplantation seems to cause susceptibility towards opportunistic mycosis [Pacholczyk, M., et al., Ann Transplant, 2011. 16(3): p. 14-16; Ceylan, B., Infez Med, 2019. 27(1): 85-92;...
Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices outcomes in patients with HAC LT, including early late complications.
To identify predictive factors associated with long-term patient and graft survival (> 15 years) in liver transplant recipients.Medical charts of all de novo adult recipients (n = 140) who were transplanted Hamburg between 1997 1999 retrospectively reviewed. In total, 155 transplantations identified this time period (15 re-transplantations). Twenty-six orthotopic (OLT) early lost to follow-up due moving other places within 1 year after transplantation. All remaining 114 patients included the...
Abstract Amanita phalloides intoxication can lead to FHF with high mortality, especially in children. There is still ongoing discussion about the optimal treatment and decision criteria for emergency liver transplantation ( LT x). Here, we summarize our experience outcomes five Five children severe A. were treated at tertiary center from 1995 2010 studied retrospectively respect clinical laboratory aspects that might help decide between x or conservative therapy only. The findings are...
Liver allocation in the Eurotransplant (ET) region has changed from a waiting time to an urgency-based system using model of end-stage liver disease (MELD) score 2006. To allow timely transplantation, pediatric recipients are allocated by assigned MELD independent severity illness. Consequences for children listed at our center were evaluated retrospective analysis all primary transplantation (LTX) deceased donors between 2002 and 2010 (110 LTX before/50 after new allocation). Of 50...
Goitre recurrence is a common problem following subtotal thyroid gland resection for multinodular goitre disease. The aim of the present study was to evaluate morbidity rate in relation side initial and redo-surgery recurrent disease.A total 1699 patients underwent consecutive surgery between 1997 2010 at our institution. One hundred eighteen (6.9%) disease after resection. nine with complete follow-up were included study.Recurrent found 79 (72.5%) ipsilateral lobe 30 (27.5%) contralateral...
Abstract Introduction Full‐split liver transplantation ( LTX ) offers the possibility to expand donor pool by utilization of one for two adults. The aim our study was analyze long‐term outcome in a large series and its applicability recent transplant era. Methods We performed retrospective analysis all full‐split from deceased donors (1999‐2015). Additionally, potential retrospectively analyzed whole organ recipients between 2006 2015 (after introduction MELD allocation). Results 44 ,...
(1) Background: Accurate hepatic artery (HA) depiction following pediatric liver transplantation (LT) is essential for graft surveillance but challenging on ultrasound (US). This study assesses if improved HA delineation can be achieved by recording two-dimensional US volumes in Color Doppler (CD) and B-flow technique. (2) Methods: Of 42 consecutive LT, 37 cases were included, was retrospectively rated using a four-point score (0 = not detectable, 3 fully separable from portal vein) within...
Evidence relating to early everolimus use after liver transplantation remains limited.Ninety-one adult patients undergoing at our center during 2007-2012 in whom therapy was initiated <3 months post-transplant were analyzed retrospectively. Everolimus started on days 1-5 50 (group 1) and day 5 41 2). Most continued receive low-dose cyclosporine (59.3%, target 50-80 ng/ml) or tacrolimus (25.3%; 3-5 ng/ml). Mean follow-up 4.6 years.One-, three- five-year patient survival rates 80.5%, 74.2%,...
Abstract In case of graft failure, re‐ LTX is the only life‐saving option but it has been associated with inferior results. This study analyzes outcome following pediatric a main focus on timely relation between initial transplant and . All at our institution 2000 2010 divided into patients primary undergoing early (≤30 days) or late (>30 after previous were analyzed. Two hundred ninety‐eight (79%), 33 (9%), 46 (12%) performed. Patient/graft survival was significantly worse for children...
Abstract IAH after LTX can impair perfusion and threaten graft viability. This study aimed to assess the feasibility of longitudinal IAP measurements as an screening method in children LTX. A cohort 23 with a mean age (range) 3.1 (3 months–14 years) who underwent between May 2017 February 2018 were evaluated retrospectively. Longitudinal compared bedside Doppler US monitoring data. In total, 425 257 examinations performed. The ± SD time expenditure for measurement was 1.9 0.4 (0.5‐3.2)...