A5000353572- Glioma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- COVID-19 and healthcare impacts
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Trauma and Emergency Care Studies
- Cancer Genomics and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Parkinson's Disease Mechanisms and Treatments
- Mass Spectrometry Techniques and Applications
- Craniofacial Disorders and Treatments
- Biomedical Ethics and Regulation
- RNA regulation and disease
- Genomics and Rare Diseases
- Migraine and Headache Studies
- Virus-based gene therapy research
- Spinal Dysraphism and Malformations
- Infectious Disease Case Reports and Treatments
- Autophagy in Disease and Therapy
- Neuroethics, Human Enhancement, Biomedical Innovations
- Soft tissue tumors and treatment
- Telemedicine and Telehealth Implementation
- Forensic and Genetic Research
University of Osijek
2015-2025
Klinički bolnički centar Osijek
2017-2025
University Hospital Centre Zagreb
2017-2025
University of Zagreb
2021
University of Belgrade
2021
Background: Cranioplasty is a routine neurosurgery treatment used to correct cranial vault abnormalities. Utilization of 3D printing technology in the field cranioplasty involving reconstruction defects emerged as an advanced possibility anatomical reshaping. The transformative impact patient-specific printed implants, focuses on their remarkable accuracy, customization capabilities, and enhanced biocompatibility. Methods: precise adaptation implants anatomies, even complex cases we...
Glioblastoma (GBM) is the most aggressive brain tumor, characterized by high recurrence rates and poor patient outcomes. Treatment failure driven multiple factors, including complex tumor heterogeneity, presence of cancer stem cells, immunosuppressive microenvironment (TME), many others. GBM’s heterogeneity underlines its ability to resist therapies adapt TME. The TME, which highly shaped hypoxia, impairs anti-tumor immunity limits efficacy immunotherapy. blood–brain barrier (BBB) remains a...
Introduction: Glioblastoma (GB) is the most aggressive glial tumor of brain with a dismal prognosis. Studies conducted during last two decades highlighted neurotropic viruses as risk factors involved in development glioblastoma. Authors present an immunohistological study single center on sixty-three archive paraffin-embedded samples GB. Patients and methods: The tissues were tested using immunohistochemistry homogenous group glioblastoma for presence Cytomegalovirus (CMV), Epstein-Barr...
Introduction: Multiple sclerosis (MS) is a chronic progressive disease of the central nervous system that results in wide range clinical manifestations. Further, 90% MS patients report some type lower urinary tract symptoms (LUTS), including sexual disorders, which impact their health-related quality life (HRQoL). The aim this study was to determine psychometric properties Croatian version King’s Health Questionnaire (KHQ) patients. Methods: Our research problem examined using KHQ, includes...
Gabriele-de Vries syndrome is a rare autosomal dominant genetic disease caused by de novo pathogenic variants in the Yin Yang 1 (YY1) gene. Individuals with this present multiple congenital anomalies, as well delay development and intellectual disability. Herein, we report case of newborn male patient novel variant Guanine Nucleotide-Binding Protein, Alpha Stimulating (GNAS) gene, which was identified whole-exome sequencing. Our suffered from large open spinal dysraphism treated surgically...
Introduction: Migraine is one of the most prominent headache disorders with a global burden over billion patients and presented as disabling painful disorder. Pathophysiological mechanism migraine not fully understood, but accepted theory suggests that caused primarily by neural dysfunction leading to secondary changes in cerebral perfusion. Methods: Authors conducted case-control study 175 patients; 88 them were migraineurs 87 health controls. Optical coherence tomography (OCT) was...
Background and objective: Chronic subdural hematoma (cSDH) is one of the most common neurosurgical entities affecting mostly elderly patients. In this study, we aimed to provide detailed characteristics surgically treated patients with cSDH evaluate outcomes between two conventional treatment methods. Materials methods: Patients burr hole craniostomy (BHC) craniotomy (CO) in tertiary centers Croatia Serbia during 2017-2019 were included study. Characteristics these prospectively collected....
: Schwannomas (Schs) are benign tumor masses that rarely occur intra-abdominally and reach larger diameters. When present, they as rare solitary nerve sheath tumors of peri-neural Schwann cells. Schwannoma mostly affects the nerves extremities, trunk, or head neck region. They more common in female patients, among patients between third fifth decade. spontaneously but could also be found association with a group genetic autosomal dominant disorders called type 2. present intra-abdominally,...
Background: Gram-positive opportunistic bacteria of the Nocardia species are responsible for a large spectrum infections, such as pneumonia, skin and more widespread conditions, including brain abscesses. Case Description: A 67-year-old male patient suffered from headache, gait disorder, vertigo week before admission to our department. An enhanced magnetic resonance imaging scan revealed mediosagittal hyperintense infratentorial lesion with concomitant compression fourth ventricle. The...
Telemedicine is a rapid tool that reduces the time until treatment for patients, which especially useful neurosurgical trauma. The aim of our study was to evaluate use telemedicine in neurosurgery during COVID-19 pandemic compared with pre-pandemic era. We assessed utilization at Department Neurosurgery University Hospital Center Osijek Croatia over timespan one year prior and first pandemic, starting date lockdown Croatia. For each period, total number consults specific clinical inquiries...
Streptococcus constellatus (SC) is a species of belonging to the anginosus group, along with and intermedius. Despite its commensal nature, underlying risk factors medical conditions might lead various anatomic site infections caused by this opportunistic pathogen. Although SC have mostly been associated bacteremia, some case reports abscess empyema formation documented. Herein, we report middle-aged female patient who initially presented radiculopathy symptoms. Subsequent neurologic imaging...
Treatment of glioblastoma is challenging due to its aggressive and highly invasive nature, no significant advances in survival have been achieved recently. The aim our retrospective study was identification predictive factors consequent outcome patients who underwent surgical oncologic treatment glioblastoma. conducted at the Department Neurosurgery, Osijek University Hospital Centre. authors designed a cohort 63 between January 1, 2012 December 31, 2017. Data were collected by reviewing...
Background and objective: The COVID-19 pandemic had a profound impact on medical practice worldwide. In this study, we aimed to investigate the trends of elective spine surgery in our department before during pandemic. Materials methods: Total number procedures due disc herniation (DH) or spinal stenosis (SS) was collected 2019–2021 Department Neurosurgery, University Hospital Center Osijek, Croatia. order elucidate potential risk factors post-pandemic period, demographic data were for...
Saul Wilson syndrome (SWS) is a rare congenital characterized by variety of symptoms, mostly skeletal changes. and were the first to describe children with extremely short stature craniofacial dysmorphism.We present case 15-years-old boy clinical radiological characteristics SWS. Genetic examination identified pathogenic heterozygous variant in COG4 gene. Magnetic resonance imaging revealed critical stenosis cranio-cervical junction (CCJ) which required surgical treatment attempt sufficient...