A5004871400- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Biochemical and Structural Characterization
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Microbial Metabolism and Applications
- Advanced biosensing and bioanalysis techniques
- Toxin Mechanisms and Immunotoxins
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Advanced Proteomics Techniques and Applications
- Cell death mechanisms and regulation
Ulsan National Institute of Science and Technology
2018-2025
Abstract The aggressive proliferation of tumor cells often requires increased glucose uptake and excessive anaerobic glycolysis, leading to the massive production secretion lactate form a unique microenvironment (TME). Therefore, regulating appropriate levels in TME would be promising approach control cell immune suppression. To effectively consume TME, oxidase (LOX) catalase (CAT) were displayed onto Aquifex aeolicus lumazine synthase protein nanoparticles (AaLS) either AaLS/LOX or...
Valosin-containing protein (VCP)/p97, an AAA+ ATPase critical for maintaining proteostasis, emerges as a promising target cancer therapy. This study reveals that targeting VCP selectively eliminates breast cells while sparing non-transformed by inducing paraptosis, non-apoptotic cell death mechanism characterized endoplasmic reticulum and mitochondria dilation. Intriguingly, oncogenic HRas sensitizes to inhibition-mediated paraptosis. The susceptibility of inhibition is attributed the...
Abstract Valosin-containing protein (VCP)/p97, an AAA + ATPase that plays a pivotal role in proteostasis, is potential therapeutic target for cancer. We report targeting VCP preferentially kills breast cancer cells over non-transformed by inducing paraptosis, non-apoptotic cell death mode accompanied the endoplasmic reticulum and mitochondria dilation. also found expression of oncogenic HRas sensitizes to inhibition-mediated paraptosis. The preferential vulnerability inhibition associated...