A5101596671- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Herpesvirus Infections and Treatments
- Legionella and Acanthamoeba research
- Cytomegalovirus and herpesvirus research
- Advanced MRI Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Functional Brain Connectivity Studies
- Diabetic Foot Ulcer Assessment and Management
- Bacillus and Francisella bacterial research
- Angiogenesis and VEGF in Cancer
- Animal Virus Infections Studies
- Infant Nutrition and Health
- Mycobacterium research and diagnosis
- SARS-CoV-2 detection and testing
- Cardiac Imaging and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Mesenchymal stem cell research
- Viral gastroenteritis research and epidemiology
- COVID-19 diagnosis using AI
- Neuroscience and Neuropharmacology Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- vaccines and immunoinformatics approaches
The University of Texas at Austin
2023-2024
Anhui Provincial Hospital
2010-2016
Anhui Medical University
2016
Cangzhou Central Hospital
2016
University of California, San Francisco
1997-1998
San Francisco VA Medical Center
1997
<b>Aims:</b> The multilineage differentiation potential of human umbilical cord mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers and tissue regeneration. present study evaluated the effects HUCMSC transplantation after angioplasty treatment diabetic foot. <b>Methods:</b> Included in were 53 patients (72 limbs) with severe symptoms Fontaine II-IV foot accompanied by varying degrees lower extremity arterial disease. randomly apportioned to a control group (25...
Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the effectiveness therapeutic antibodies and vaccines. Developing a coronavirus vaccine that offers greater breadth protection against current future VOCs would eliminate need to reformulate COVID-19 Here, we rationally engineer sequence-conserved S2 subunit spike protein characterize resulting S2-only antigens. Structural studies demonstrate introduction interprotomer disulfide bonds can lock in prefusion trimers,...
The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants concern that accumulate most sequence modifications in immunodominant S1 subunit. S2, contrast, evolutionarily conserved region and can elicit broadly neutralizing protective antibodies. Yet, S2's usage as an alternative vaccine strategy hampered its general instability. Here, we use a simulation-driven approach to design S2-only...
Abstract Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein required for viral entry. HCMV vaccine candidates containing gB have demonstrated moderate clinical efficacy, but no has been FDA-approved. Here, we used structure-based design to identify and characterize amino acid substitutions that stabilize in its metastable prefusion conformation. One variant two engineered interprotomer disulfide bonds cavity-filling (gB-C7), displayed increased expression...
Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein required for viral entry. HCMV vaccine candidates containing gB have demonstrated moderate clinical efficacy, but no has been approved. Here, we used structure-based design to identify and characterize amino acid substitutions that stabilize in its metastable prefusion conformation. One variant two engineered interprotomer disulfide bonds cavity-filling (gB-C7), displayed increased expression...
The ongoing evolution of SARS-CoV-2 into more easily transmissible and infectious variants has provided unprecedented insight mutations enabling immune escape. Understanding how these affect the dynamics antibody-antigen interactions is crucial to development broadly protective antibodies vaccines. Here we report characterization a potent neutralizing antibody (N3-1) identified from COVID-19 patient during first disease wave. Cryogenic electron microscopy revealed quaternary binding mode...
Mycobacterium tuberculosis (Mtb) is known to be responsible for (TB), but the pathogenesis of this disease and host defense mechanisms involved are, most part, poorly understood. In study, we divided 30 male C57BL/6 mice into control infection groups, following injection with physiological saline or Mtb, respectively, euthanized five from each group on days 1, 3, 7. TNF-α IL-10 levels were measured by enzyme-linked immunosorbent assay flow cytometry, latter also being performed assess...
Abstract The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants concern that accumulate most sequence modifications in immunodominant S1 subunit. S2, contrast, evolutionarily conserved region and can elicit broadly neutralizing protective antibodies. Yet, S2’s usage as an alternative vaccine strategy hampered its general instability. Here, we use a simulation-driven approach to design...
Rotavirus is the most common pathogens of diarrheal diseases in children. infection lead to not only gastrointestinal symptoms but also a variety extraintesu'nal manifestations. The pathogenesis RV diarrhea and especially viremia related multiple factors. infectious damaged cell intercellular connections,the non-structural protein 4, heat shock hsc70 other Pathogenesis may be secretion inflammatory mediators vivo expression cytokines after infection. Key words: Rotavirus; Infantile...