A5007247705- Dermatological diseases and infestations
- Rabies epidemiology and control
- Nail Diseases and Treatments
- Vector-borne infectious diseases
- Microbial infections and disease research
- Zoonotic diseases and public health
- Viral gastroenteritis research and epidemiology
- Milk Quality and Mastitis in Dairy Cows
- Salmonella and Campylobacter epidemiology
- Tuberculosis Research and Epidemiology
- Animal Disease Management and Epidemiology
- Tattoo and Body Piercing Complications
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Yersinia bacterium, plague, ectoparasites research
- Virus-based gene therapy research
- Genital Health and Disease
- Bacterial Identification and Susceptibility Testing
- Bartonella species infections research
- Study of Mite Species
- Phytoestrogen effects and research
- Parasites and Host Interactions
- HIV/AIDS Impact and Responses
Makerere University
2015-2025
Background Animal tungiasis is believed to increase the prevalence and parasite burden in humans. reservoirs of Tunga penetrans differ among endemic areas their role epidemiology had never been investigated Uganda. Methods Findings To identify major animal relative importance transmission Uganda, a cross sectional study was conducted rearing households 10 villages Bugiri District. T. infections were detected pigs, dogs, goats cat. The prevalences with ranged from 0% 71.4% (median 22.2) for...
Tungiasis is an important but highly neglected cause of morbidity in resource-poor communities Latin America and sub-Saharan Africa. Data upon which implementation control measures can be based are scarce. Before piloting integrated tungiasis program three parishes Napak district, Uganda, a cross-sectional survey involving the systematic examination humans domestic mammals was implemented to establish occurrence patterns tungiasis. The study population 5482 residents, 4035 (73.6%)...
Abstract Background Tungiasis is a neglected tropical skin disease caused by the sand flea Tunga penetrans . Female fleas penetrate skin, particularly at feet, and cause severe inflammation. This study aimed to characterize burden in two highly affected regions Kenya, test use of thermography detect tungiasis-associated inflammation create new two-level classification severity suitable for mapping, targeting, monitoring interventions. Methods From February 2020 April 2021, 3532 pupils age...
Background The sand flea, Tunga penetrans , is the cause of a severely neglected parasitic skin disease (tungiasis) in tropics and has received little attention from entomologists to understand its transmission ecology. Like all fleas, T . environmental off-host stages presenting constant source reinfection. We adapted Berlese-Tullgren funnel method using heat light bulbs extract soil samples identify major development sites within rural households Kenya Uganda. Methods findings Simple,...
Abstract Background Tungiasis is a neglected tropical disease which common in impoverished communities. In sub-Saharan Africa, it caused by female sand fleas, Tunga penetrans , and pigs are amongst the major domestic animal reservoirs. Depending on environment, tungiasis occurs throughout year or preferentially dry seasons. This study investigated changes flea abundance associated morbidity during season. Methods lesions were counted staged 35 22 households with at least one affected pig....
Tunga penetrans (Insecta, Siphonaptera, Tungidae) causes severe morbidity among heavily infected humans and animals in Latin America sub-Saharan Africa. The clinical pathology of tungiasis has never been studied systematically. This was a cross-sectional study conducted between January to March 2015, aimed at describing tungiasis-associated 121 20 T. penetrans-infected pigs dogs, living nine five endemic rural villages respectively located Bugiri District, Busoga, Uganda. parasite load...
There are increasing reports of antimicrobial treatment failures for bacterial diseases poultry in Uganda. The paucity data on resistance (AMR) pathogenic bacteria Uganda is a major setback to AMR control. This study investigated the occurrence fowl typhoid, colibacillosis, and associated pathogens from 2012 2018. Laboratory records Central Diagnostic (CDL), National Veterinary Facility located at Makerere University, were reviewed. Archived isolates causative two also evaluated AMR....
Neglected tropical diseases are known to be highly stigmatized conditions. This study investigates tungiasis-related stigma and control practices in the impoverished Napak District rural northeastern Uganda, where tungiasis is hyperendemic effective treatment unavailable. We conducted a questionnaire survey with main household caretakers (n = 1329) 17 villages examined them for tungiasis. The prevalence of among our respondents was 61.0%. Questionnaire responses showed that perceived as...
Porcine Circovirus type 2 (PCV2) infections and associated diseases have been rarely studied in Africa. There is no report of PCV2 infection-associated morbidity the level awareness stakeholders has never investigated Uganda. This cross sectional survey occurrence – systemic disease (PCV2-SD) among pigs Central Data were collected using questionnaires, Focus Group Discussions (FGDs), key informant interviews laboratory investigations. All respondents (n = 131) farmers attending FGDs 31) had...
Cattle and poultry enterprises are among the major contributors to food security socioeconomic empowerment of households in Uganda. However, various diseases constrain their productivity. A two-year retrospective study between April 2012 March 2014 was conducted using records for cattle diagnosed at Central Diagnostic Laboratory (CDL) determine prevalent The laboratory received 836 samples from (36.3%) (63.7%). Of samples, 47.5% had a definitive diagnosis disease causation. Most were...
Towards the improvement of stakeholders' awareness animal tungiasis, we report 10 unusual severe clinical cases pig tungiasis which were associated with very high infection intensities T. penetrans in an endemic area. Morbidity ten pigs sand flea detected during transmission seasons area Busoga sub region, Uganda is described detail. The presented a number embedded fleas (median = 276, range 141–838). Acute manifestations due to included ulcerations (n 10), abscess formation 6) and lameness...
Tungiasis ensues from the penetration and burrowing of female sand fleas (Tunga spp.; Siphonaptera: Tungidae) in skin mammals. There are few case reports severe tungiasis goats these cases Tunga species were not most clearly identified. Two caused by penetrans goat kids tungiasis-endemic rural Uganda reported. These first reported outside South America.
Abstract Background Tungiasis, a neglected tropical parasitosis, disproportionately affects children. Few empirical studies have reported neurocognitive and mental health outcomes of children with ectoparasitic skin diseases like tungiasis. Pathophysiology tungiasis suggests it could detrimentally affect cognition behaviour. This study pioneered the investigation in Methods was multi-site cross-sectional including 454 quasi-randomly sampled school-children aged 8–14 from 48 randomly selected...
Background In endemic communities, zoonotic tungiasis, a severe skin disease caused by penetrating female sand fleas, is public health hazard causing significant human and animal morbidity. No validated drugs are currently available for treatment of tungiasis. Due to the reservoir in domestic animals, integrated management tungiasis required avert its negative effects. Methods principal findings A topical aerosol containing chlorfenvinphos 4.8%, dichlorphos 0.75% gentian violet 0.145%...
Abstract Background Mastitis and associated antimicrobial resistance (AMR) are major challenges to the dairy industry worldwide. Objective This study aimed expose mastitis burden, causative bacteria drivers for mastitis‐causing multi‐drug‐resistant (MDR) Staphylococci infectivity in cows on farms Wakiso district, Uganda. Methods On 22 farms, practices were documented using questionnaires, 175 screened by California test. Composite milk samples from positive reactors submitted laboratory...
Tungiasis is a neglected tropical disease (NTD) that can cause significant suffering and disability. Health promotion an important pillar in NTD control programs, assuming better knowledge contributes to reduced risk behavior of infection. The study objective was assess tungiasis-related its translation into practices rural highly endemic setting Karamoja, Northeastern Uganda. We applied mixed-methods design on household community level. A semi-quantitative questionnaire knowledge,...
Abstract Tungiasis (sand flea disease) is a neglected tropical disease that endemic in Sub‐Saharan Africa and Latin America. causes pain, mobility restrictions, stigmatisation reduced quality of life. Very severe cases with hundreds sand fleas have been described, but treatment such has never studied systematically. During larger community‐based tungiasis control programme hyperendemic region Karamoja, northeastern Uganda, 96 very were identified treated the dimeticone formula NYDA®. They...