A5009462004- Herpesvirus Infections and Treatments
- Tuberculosis Research and Epidemiology
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Ubiquitin and proteasome pathways
- Biochemical and Molecular Research
- Endoplasmic Reticulum Stress and Disease
- Viral Infections and Immunology Research
- vaccines and immunoinformatics approaches
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- Sirtuins and Resveratrol in Medicine
- Gut microbiota and health
- Toxin Mechanisms and Immunotoxins
- Mycobacterium research and diagnosis
University of Oslo
2020-2022
Charité - Universitätsmedizin Berlin
2010-2016
MSB Medical School Berlin
2016
University of Bergen
2013-2014
Adeno-associated virus type 2 (AAV) is known to establish latency by preferential integration in human chromosome 19q13.42. The AAV non-structural protein Rep appears target a site called AAVS1 simultaneously binding Rep-binding sites (RBS) present on the genome and within AAVS1. In absence of Rep, as case with vectors, chromosomal rare random. For genome-wide survey wildtype linker-selection-mediated (LSM)-PCR strategy was designed retrieve AAV-chromosomal junctions. DNA sequence...
ABSTRACT Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from humans or nonhuman primates have so far not been proven to be causes of human disease. In view the increasing success AAV-derived vectors in gene therapy, definition vivo sites wild-type persistence and clinical consequences its reactivation is becoming increasingly urgent. Here, we identify presumed cell type for host by highly sensitive PCRs developed...
Reactive nitrogen species (RNS) are secreted by human cells in response to infection Mycobacterium tuberculosis (Mtb). Although RNS can kill Mtb under some circumstances, adapt and survive the presence of a process that involves modulation gene expression. Previous studies focused primarily on stress-related changes transcriptome. This study unveils proteome sub-lethal dose nitric oxide (NO) over several hours exposure. Proteins were identified using liquid chromatography coupled with...
Despite the discovery of tubercle bacillus more than 130 years ago, its physiology and mechanisms virulence are still not fully understood. A comprehensive analysis proteomes members human-adapted Mycobacterium tuberculosis complex (MTBC) lineages 3, 4, 5 7 was conducted to better understand evolution other physiological characteristics. Unique shared proteomic signatures in these modern, pre-modern ancient MTBC lineages, as deduced from quantitative bioinformatics analyses high-resolution...