A5061571833- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Virus-based gene therapy research
- COVID-19 diagnosis using AI
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Advanced biosensing and bioanalysis techniques
- Diet, Metabolism, and Disease
- Otolaryngology and Infectious Diseases
- Oral Health Pathology and Treatment
- Yersinia bacterium, plague, ectoparasites research
- Dermatological and COVID-19 studies
- Global Health Workforce Issues
- Hepatitis Viruses Studies and Epidemiology
- Probiotics and Fermented Foods
- Bacillus and Francisella bacterial research
- Genetics, Bioinformatics, and Biomedical Research
- Microbial Metabolites in Food Biotechnology
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Liver Disease and Transplantation
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Biofuel production and bioconversion
Heidelberg University
2020-2022
University Hospital Heidelberg
2020-2022
University of Basrah
2021
Charité - Universitätsmedizin Berlin
2016
MSB Medical School Berlin
2016
A colorimetric isothermal RNA amplification method was shown to detect SARS-CoV-2 in clinical samples with excellent sensitivity and specificity.
Rapid large-scale testing is essential for controlling the ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic pipeline SARS-CoV-2 presence in patients with an infection predominantly based on pharyngeal swabs, from which viral RNA extracted using commercial kits, followed by reverse transcription and quantitative PCR detection. As a result large demand testing, extraction kits may be limited and, alternatively, non-commercial protocols...
ABSTRACT Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from humans or nonhuman primates have so far not been proven to be causes of human disease. In view the increasing success AAV-derived vectors in gene therapy, definition vivo sites wild-type persistence and clinical consequences its reactivation is becoming increasingly urgent. Here, we identify presumed cell type for host by highly sensitive PCRs developed...
Abstract Background At the entry site of respiratory virus infections, oropharyngeal microbiome has been proposed as a major hub integrating viral and host immune signals. Early studies suggested that infections with severe acute syndrome coronavirus 2 (SARS-CoV-2) are associated changes upper lower airway microbiome, specific microbial signatures may predict disease 2019 (COVID-19) illness. However, results not conclusive, critical illness can drastically alter patient’s through multiple...
Abstract The COVID-19 pandemic caused by the novel SARS-CoV-2 virus poses a significant public-health problem. In order to control pandemic, rapid tests for detecting existing infections and assessing spread are critical. Approaches detect viral RNA based on reverse transcription loop-mediated isothermal amplification (RT-LAMP) hold outstanding promise towards greatly simplified broadly applicable testing methods. RT-LAMP assays appear more robust than qPCR-based methods only require...
Abstract Rapid large-scale testing is essential for controlling the ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic pipeline SARS-CoV-2 presence in patients with an infection predominantly based on pharyngeal swabs, from which viral RNA extracted using commercial kits followed by reverse transcription and quantitative PCR detection. As a result large demand testing, extraction may be limited alternative, non-commercial protocols are...
Abstract Coronavirus 2 (SARS-CoV-2) infection and the resulting COVID-19 illness vary from asymptomatic disease, mild upper respiratory tract infection, pneumonia 1 , to a life-threatening multi-organ failure with case fatality rates ranging 0.27–13.4% 2,3 . Despite increasing knowledge of clinical immunological features underlying 1,4−6 biological variables explaining course its severity remain elusive. At entry site SARS-CoV2, oropharyngeal microbiome represents hub integrating viral...
A total of one hundred and fifty cow, buffalo, sheep milk samples were collected from several markets in Basrah, Iraq (50 each species). All subjected to enrichment TSB cold PBS, then cultured on YSA agar order obtain Yersinia species. The highest growth obtained by was seen cow (24%) followed buffalo (22%) (12%). results PBS showed the (14%) (8%) (2%). that both contaminated Y. enterocolitica at 8% while prevalence 4%. Ten isolates different sources current study examined for their...
Abstract Background and Aims Hepatitis E virus (HEV) is an increasingly recognised pathogen in industrialised countries, particular genotype 3. Patients with underlying liver disease are at increased risk for severe course of the infection. Additionally, patients receiving immunosuppressive therapy can develop chronic HEV infection, which may cause further damage ultimately lead to cirrhosis, decompensation or death. Methods This retrospective study assessed 1023 on waiting list...