A5027955466- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Sex work and related issues
- COVID-19 epidemiological studies
- HIV-related health complications and treatments
- ICT in Developing Communities
- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- COVID-19 Clinical Research Studies
- Adolescent and Pediatric Healthcare
- Mobile Health and mHealth Applications
- Genomics and Phylogenetic Studies
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Herpesvirus Infections and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Genomics and Rare Diseases
- Child Development and Digital Technology
- Reproductive tract infections research
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
Milken Institute
2018-2023
George Washington University
2018-2023
An estimated 50% of adolescents and young adults (AYA) living with HIV are failing to adhere prescribed antiretroviral treatment (ART). Digital games effective in chronic disease management; however, research on gaming improve ART adherence among AYA is limited.
The COVID-19 pandemic has disproportionately affected older people, people with underlying health conditions, racial and ethnic minorities, socioeconomically disadvantaged, living HIV (PWH). We sought to describe vaccine hesitancy associated factors, reasons for hesitancy, uptake over time in PWH Washington, DC.
Women with syndemic conditions, i.e., two or more co-occurring epidemics, are at elevated risk for HIV acquisition and therefore prime candidates pre-exposure prophylaxis (PrEP). However, PrEP uptake remains low among women, especially Black Hispanic women. This study examined associations of conditions attitudes the moderating effect race ethnicity. In 2017, 271 non-Hispanic Black, White, Hispanic, PrEP-eligible women engaged in care Planned Parenthood northeastern region U.S. completed an...
Abstract We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0–19 years) in the United States report an increased rate change BMI-for-age z score after initiating integrase strand transfer inhibitors (+0.19 units/year [95% confidence interval, .01–.37]; P = .036) for median follow-up 527.5 days.
Abstract Background COVID-19 has not only taken a staggering toll in terms of cases and lives lost, but also its psychosocial effects. We assessed the impacts pandemic large cohort people with HIV (PWH) Washington DC evaluated association various demographic clinical characteristics impacts. Methods From October 2020 to December 2021, Cohort participants were invited complete survey capturing outcomes influenced by pandemic. Some variables collected survey, results matched additional data...
The DC Cohort is an ongoing longitudinal observational study of persons living with HIV. To better understand HIV-1 drug resistance and potential transmission clusters among these participants, we performed targeted, paired-end next-generation sequencing (NGS) protease, reverse transcriptase integrase amplicons. We elected to use free, publicly-available software (HyDRA Web, Stanford HIVdb HIV-TRACE) for data analyses so that laboratory personnel without extensive bioinformatics expertise...
Abstract Washington, DC continues to experience a generalized HIV-1 epidemic. We characterized the local phylodynamics of in using next-generation sequencing (NGS) data. Viral samples from 68 participants 2016 through 2017 were sequenced and paired with epidemiological Phylogenetic network inferences, drug resistant mutations (DRMs), subtypes diversity estimations completed. Haplotypes reconstructed infer transmission clusters. Phylodynamic inferences based on polymerase ( pol ) envelope...
Abstract Background Direct oral anticoagulants (DOACs) have become first-line treatment for venous thrombotic events. DOAC prescribing trends among people living with human immunodeficiency virus (PWH) are not well described. The coadministration of DOACs the antiretroviral (ARV) pharmacokinetic boosters ritonavir (RTV) or cobicistat (COBI) may be complicated by interactions. Methods A longitudinal cohort study was conducted using D.C. Cohort Database in Washington, D.C., from January 2011...
Two strategies of the US Ending HIV Epidemic initiative are early diagnosis infections via widespread testing and prevention new using pre-exposure prophylaxis (PrEP). These particularly important for adolescents young adults (AYAs) who disproportionately affected by HIV, if they identify as Black and/or lesbian, gay, bisexual, transgender, queer or questioning, others (LGBTQ+). This study will develop test an interactive life-simulation game in which players can enact real-life behaviors...
Objective: Adolescents and young adults (AYAs) account for >20% of new HIV diagnoses in the United States, yet >50% are unaware their infection. Digital gaming is widespread among youth has proven efficacious other disease areas; thus, we sought to determine whether a life-and-dating simulation game increase testing would be acceptable AYAs. Materials Methods: Focus groups surveys were administered health care providers AYAs Washington, DC. shown that incorporated Centers Disease Control...
Molecular epidemiology (ME) is one tool used to end the HIV epidemic in United States. We combined clinical and behavioral data with sequence identify any overlap clusters generated from different datasets; characterize transmission clusters; correlates of clustering among people living (PLWH) Washington, District Columbia (DC). First, Sanger sequences DC Cohort participants, a longitudinal study, were next-generation (NGS) participants ME substudy clusters. Next, demographic self-reported...
Adolescents and young adults (AYA) in the United States, Washington, District of Columbia (DC), specifically, are disproportionately affected by HIV. Both national Ending HIV Epidemic initiative DC-specific plans emphasize testing, innovative strategies to encourage testing among AYA needed.The purpose this study is identify sexual behaviors, knowledge, perceptions (eg, susceptibility severity), perceived barriers facilitators at risk for DC.This was part a larger determine acceptability...
Integrating pregnancy and HIV prevention services would make reproductive health care settings an optimal venue for the promotion delivery of preexposure prophylaxis (PrEP) to cisgender women. However, these have been slow adopt PrEP. Planned parenthood clinicians leaders possess critical insight that can help accelerate PrEP implementation in elements Consolidated Framework Implementation Research (i.e., relative priority intervention staff, climate, available resources implement...
Abstract Integrase inhibitors (INSTIs) are recommended by expert panels as initial therapy for people with HIV. Because there can be disparities in prescribing and uptake of novel and/or therapies, this analysis assessed potential INSTI using a combined data set from the Johns Hopkins HIV Clinical Cohort DC Cohort. We performed multivariable logistic regression to identify factors associated ever being prescribed an INSTI. Disparities were noted, including clinic location, age, transgender....
<sec> <title>BACKGROUND</title> An estimated 50% of adolescents and young adults (AYA) living with HIV are failing to adhere prescribed antiretroviral treatment (ART). Digital games effective in chronic disease management; however, research on gaming improve ART adherence among AYA is limited. </sec> <title>OBJECTIVE</title> We assessed the feasibility acceptability videogaming adherence. <title>METHODS</title> Focus group discussions (FGDs) surveys were administered healthcare providers...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
This study explored virological outcomes of two-drug (2DRs) and three-drug (3DRs) antiretroviral regimens in adults with HIV the DC Cohort. We analyzed 310 treatment-experienced sustained RNA ≤50 copies/mL at baseline, 53 whom switched to 2DRs 257 continued 3DRs. Adults on 3DRs had similar demographics (median age 53.3 years, 76.8% cisgender male, 76.1% Black). more participants ≥2 comorbidities (62.3% vs. 42.8%, p = .019), a longer time since diagnosis years 20.4 13.2, .017), received...
<sec> <title>BACKGROUND</title> Two strategies of the US Ending HIV Epidemic initiative are early diagnosis infections via widespread testing and prevention new using pre-exposure prophylaxis (PrEP). These particularly important for adolescents young adults (AYAs) who disproportionately affected by HIV, if they identify as Black and/or lesbian, gay, bisexual, transgender, queer or questioning, others (LGBTQ+). This study will develop test an interactive life-simulation game in which players...
<sec> <title>BACKGROUND</title> Adolescents and young adults (AYA) in the United States, Washington, District of Columbia (DC), specifically, are disproportionately affected by HIV. Both national Ending HIV Epidemic initiative DC-specific plans emphasize testing, innovative strategies to encourage testing among AYA needed. </sec> <title>OBJECTIVE</title> The purpose this study is identify sexual behaviors, knowledge, perceptions (eg, susceptibility severity), perceived barriers facilitators...