A5018333739- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Cellular transport and secretion
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Nanomaterials and Printing Technologies
- Antimicrobial Peptides and Activities
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Escherichia coli research studies
- Bacterial Genetics and Biotechnology
- Microfluidic and Capillary Electrophoresis Applications
- Lipid Membrane Structure and Behavior
- Viral gastroenteritis research and epidemiology
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Biomedical Research and Pathophysiology
- Infection Control in Healthcare
- Quantum-Dot Cellular Automata
- Cancer therapeutics and mechanisms
- Parasites and Host Interactions
- Biosensors and Analytical Detection
- Erythrocyte Function and Pathophysiology
- Immune cells in cancer
- Nanopore and Nanochannel Transport Studies
Indian Institute of Science Bangalore
2019-2024
Newcastle University
2024
Newcastle upon Tyne Hospital
2024
Indian Institute of Chemical Biology
2020-2022
Council of Scientific and Industrial Research
2020
University of Engineering & Management
2016-2017
Institute of Engineering
2017
Salmonella is a facultative intracellular pathogen that has co-evolved with its host and also developed various strategies to evade the immune responses. recruits an array of virulence factors escape from defense mechanisms. Previously chitinase A ( chiA ) was found be upregulated in . Although studies show several structurally similar chitinases chitin-binding proteins (CBP) many human pathogens have profound role aspects pathogenesis, like adhesion, virulence, evasion, intravacuolar not...
Macrophages engulf pathogens into dynamic phagosomes, which many bacteria manipulate for survival. However, isolating pure pathogen-containing phagosomes remains challenging. Here, we developed a novel flow cytometry-based isolation and ultrasensitive proteomics approach to analyse phagosomal bacterial proteomes from macrophages infected with wild-type (WT) Salmonella enterica serovar Typhimurium (STM), ΔphoP mutant, or dead WT at 30 min 4 hrs post-infection. Our provides higher throughput,...
Abstract Plasma‐activated water (PAW) is emerging as a green alternative technology in biomedicine due to its rich and diverse aqueous reactive nitrogen oxygen species (RONS). This study explores how configure pin (P2W) discharge generate neutral pH high‐strength plasma‐activated (hs‐PAW) bactericidal activity on hypervirulent multidrug resistance (MDR) pathogens. The factors affecting the strength of PAW, namely: type, PAW temperature, plasma enclosure, activation time, were studied...
Abstract Intracellular membrane fusion is mediated by membrane‐bridging complexes of soluble N ‐ethylmaleimide‐sensitive factor attachment protein receptors (SNAREs). SNARE proteins are one the key players in vesicular transport. Several reports shed light on intracellular bacteria modulating host machinery to establish infection successfully. The critical SNAREs macrophages responsible for phagosome maturation Syntaxin 3 (STX3) and 4 (STX4). Reports also suggest that Salmonella actively...
Immortalised cell lines that mimic their primary counterparts are fundamental to research, particularly when large numbers required. Here, we report immortalisation of bone marrow-derived macrophages (iBMDMs) using the J2 virus resulted in loss a protein interest, MSR1, WT cells by an unknown mechanism. This led us perform in-depth mass spectrometry-based proteomic characterisation common murine macrophage (J774A.1, RAW264.7, and BMA3.1A7), comparison with iBMDMs, as well BMDMs from both...
The presented paper is based on a new technology, QCA (Quantum-dot Cellular Automata), promising successor for CMOS transistor technology. implementation of logic circuits by the traditional devices (eg. transistors, diodes and resistors are replaced quantum (quantum dots or single domain nano magnets). use quantum-dots emerging technology implementing digital systems at nano-scale level. This technique depending interaction electrons within dots. project proposes layouts decoder QCA....
The recent rise in the incidence of hepatitis B virus (HBV) infections a densely populated city eastern India ("mixing vessel" people varied socio-economic and immune status) prompted this study. Applying saliva on fingers for enumerating bank notes is common practice Indian subcontinent. Paper may be potential source "horizontal" transmission virus, especially if there are cuts/bruises oral mucous membrane or skin.To investigate whether paper currencies could plausible mode horizontal HBV...
The diagnostic information and the prescription of any health discrepancies are generated by checking certain parameters with an expert verified medical database. taken as input via sensors or through keyboard. microcontroller based intelligent system is designed help data base.
Abstract Intracellular pathogens rely on manipulating host endocytic pathways to ensure survival. Legionella and Chlamydia exploit SNARE proteins, with cleaving syntaxin 17 (STX17) interacting VAMP8 VAMP7. Similarly, Salmonella targets the host’s endosomal fusion machinery, using SPI effectors like SipC SipA interact 6 (STX6) 8 (STX8), respectively, maintaining its vacuolar niche. Recent evidence highlights 7 (STX7), a Qa-SNARE involved in endo-lysosomal fusion, as potential target. BioID...
In the present work, experiments are conducted to understand consequence of stresses generated by flowing fluid on bacterial morphology and virulence in microfluidic channels.
Abstract Deposits of biofluid droplets on surfaces (such as respiratory formed during an expiratory event fallen surfaces) are composed the water-based salt-protein solution that may also contain infection (bacterial/viral).The final patterns deposit dictated by composition fluid and flow dynamics within droplet. This work reports spatio-temporal, topological regulation deposits control motility bacteria tweaking inside using non-contact vapor-mediated interactions. When evaporated a glass...
ABSTRACT A droplet of blood, when evaporated on a surface, leaves dried residue—the fractal patterns formed the residues can act as markers for infection present in blood. Exploiting unique found naturally we propose Point-of-Care (POC) diagnostic tool detecting broad-spectrum bacterial infections (such Enterobacter aerogenes, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, Salmonella Typhi ) The diagnosis process is straightforward be...