A5038364292- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Effects in Electronics
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Electron and X-Ray Spectroscopy Techniques
- Particle accelerators and beam dynamics
- Particle Detector Development and Performance
- Radiation Effects and Dosimetry
- Atomic and Molecular Physics
- X-ray Spectroscopy and Fluorescence Analysis
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Particle Accelerators and Free-Electron Lasers
- Mass Spectrometry Techniques and Applications
- Field-Flow Fractionation Techniques
- Transplantation: Methods and Outcomes
- Nuclear reactor physics and engineering
- Integrated Circuits and Semiconductor Failure Analysis
- Laser Design and Applications
- Advancements in Photolithography Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Silicon Carbide Semiconductor Technologies
- Head and Neck Cancer Studies
MedAustron
2015-2024
Ludwig-Maximilians-Universität München
2020
Universitätsklinik für Strahlentherapie
2020
University of Vienna
2020
Centre Léon Bérard
2010-2013
Ion Beam Applications (Belgium)
2010-2012
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2010-2011
Université Claude Bernard Lyon 1
2010-2011
Centre National de la Recherche Scientifique
2010-2011
Inserm
2010-2011
GATE (Geant4 Application for Emission Tomography) is a Monte Carlo simulation platform developed by the OpenGATE collaboration since 2001 and first publicly released in 2004. Dedicated to modelling of planar scintigraphy, single photon emission computed tomography (SPECT) positron (PET) acquisitions, this widely used assist PET SPECT research. A recent extension platform, as V6, now also enables x-ray radiation therapy experiments. This paper presents an overview main additions improvements...
This work proposes a generic method for modeling scanned ion beam delivery systems, without simulation of the treatment nozzle and based exclusively on data library (BDL) measurements required planning systems (TPS). To this aim, new tools dedicated to plan were implemented in Gate Monte Carlo platform. The was applied from IBA proton pencil scanning delivery. Optical energy parameters system modeled using set depth–dose profiles spot sizes measured at 27 therapeutic energies. For further...
The GEANT4-based GATE Monte Carlo (MC) platform was initially focused on PET and SPECT simulations.The new release v6.0 (February 2010) proposes tools dedicated for radiation therapy simulations.In this work, we investigated some part of extension proposed a general methodology Linac simulations.Details the modeling 6 MV photon beam delivered by an Elekta Precise Linac, with fields ranging from 5 × to 30 cm 2 at isocenter are presented.Comparisons were performed measurements in water.The...
Active scanning delivery systems take full advantage of ion beams to best conform the tumor and spare surrounding healthy tissues; however, it is also a challenging technique for quality assurance. In this perspective, we upgraded GATE/GEANT4 Monte Carlo platform in order recalculate treatment planning system (TPS) dose distributions active systems. A method that allows evaluating TPS with GATE has been developed applied XiO (Elekta), IBA proton pencil beam (PBS) system. First, evaluated...
The dose core of a proton pencil beam (PB) is enveloped by low area reaching several centimeters off the central axis and containing considerable amount dose. Adequate modeling different components PB profile is, therefore, required for accurate calculation. In this study, we experimentally validated one electromagnetic two nuclear scattering models in GATE/Geant4 calculation beams therapeutic energy window (62-252 MeV) with without range shifter (RaShi).The multiple Coulomb (MCS) model was...
Purpose GATE‐RTion is a validated version of GATE for clinical use in the field light ion beam therapy. This paper describes project and illustrates its potential through applications developed three European centers delivering scanned proton carbon treatments. Methods collaborative framework provided by OpenGATE collaboration. It contains release based on specific Geant4 version, set tools to integrate into environment network users. Results Three are presented: Proton radiography at Centre...
To describe the implementation of dosimetry equipment and phantoms into clinical practice light ion beam therapy facilities. This work covers not only standard such as computerized water scanners, films, 2D-array, thimble, plane parallel ionization chambers, but also specifically devoted to pencil scanning delivery technique columns, scintillating screens or multilayer chambers.Advanced acceptance testing procedures developed at MedAustron complementary proposed by manufacturer are...
Purpose Geant4 is a multi‐purpose Monte Carlo simulation tool for modeling particle transport in matter. It provides wide range of settings, which the user may optimize their specific application. This study investigates GATE/Geant4 parameter settings proton pencil beam scanning therapy. Methods GATE8.1/Geant4.10.3.p03 (matching versions used GATE‐RTion1.0) simulations were performed with set prebuilt physics lists (QGSP_BIC, QGSP_BIC_EMY, QGSP_BIC_EMZ, QGSP_BIC_HP_EMZ), using 0.1mm‐10mm as...
This paper describes the clinical implementation and medical commissioning of MedAustron Particle Therapy Accelerator (MAPTA) for non-isocentric scanned proton beam treatments.Medical physics involvement during technical work is presented. Acceptance testing procedures, including advanced measurement methods intra-spill variations, are defined. Beam monitor calibration using two independent based on a dose-area product formalism described. Emphasis given to specificities related irradiation,...
This study aims at selecting and evaluating a ripple filter design compatible with non-isocentric proton carbon ion scanning beam treatment delivery for compact nozzle. The use of treatments when the patient is shifted as close possible towards nozzle exit allows reduction in air gap thus an improvement quality delivery. Reducing less important ions, but filters are still necessary beams to reduce number energy steps required deliver homogeneous SOBP. proper selection also transverse...
This work describes the dosimetric commissioning of treatment planning system (TPS) RayStation v6.1 from RaySearch Laboratories (Stockholm, Sweden) for a synchrotron-based scanned proton beam delivery with isocentric and non-isocentric setups at MedAustron. Focus was on comparison pencil (PBv4.1) Monte Carlo (MCv4.0) calculation algorithms. Commissioning dose calculations done first 1D/2D where performance model in reproducing properties single static beams mono-energetic layers multiple...
PET is a promising technique for in vivo treatment verification hadrontherapy. Three main geometries dedicated to in-beam monitoring have been proposed the literature: dual-head geometry, OpenPET geometry and slanted-closed ring geometry. The aim of this work characterize performance two these detectors realistic clinical conditions. Several configurations systems were simulated using GATE v6.2. For configuration, aperture angles (15° 45°) studied. system, gaps between rings investigated...
Abstract Purpose Reporting on the first implementation of a proton dedicated commercial device (IBA Sphinx/Lynx) for daily Quality Assurance (QA) scanned and carbon ion beams. Methods Daily QA trendlines over more than 3 years protons 2 ions have been acquired. Key parameters were reviewed, namely spot size position, beam range, Bragg peak width, coincidence (between imaging system isocenters), homogeneity dose. Results The performance equipment was evaluated. allowed us to detect machine...
Abstract This work investigates the operational acquisition time limits of Timepix3 and Timepix2 detectors operated in frame mode for high-count rate high deposited energy transfer particles. Measurements were performed using alpha particles from a 241 Am laboratory source proton carbon ion beams synchrotron accelerator. The particle count upper limit is determined by overlapping per-pixel signals, identifiable hits per pixel counter > 2, indicating need to decrease time. On other hand,...
Purpose To develop a computer‐driven and thus less user‐dependent method, allowing for simple straightforward generation of Monte Carlo (MC) beam model scanned proton carbon ion delivery system. Methods In first step, experimental measurements were performed energies in the available energy ranges. Data included depth dose profiles measured water spot sizes air at various isocenter distances. Using an automated regularization‐based optimization process (AUTO‐BEAM), GATE/Geant4 models...
Patient specific quality assurance can be improved using an independent dose calculation system. In addition, the implementation of such a system may support light ion beam therapy facilities in reducing needs for time, by substituting some experimental patient-specific procedures calculation. The GATE-RTion-based IDEAL was developed this purpose. It built DICOM-in, DICOM-out fashion, easy integration into state-of-the-art technology-based workflow scanned therapy. This article describes...