A5072909816- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Boron Compounds in Chemistry
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Bone Tumor Diagnosis and Treatments
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Effects of Radiation Exposure
- Head and Neck Surgical Oncology
- Advanced X-ray and CT Imaging
- Particle accelerators and beam dynamics
- Cancer, Hypoxia, and Metabolism
- Anatomy and Medical Technology
- Global Healthcare and Medical Tourism
- Metallurgical Processes and Thermodynamics
- Healthcare Systems and Public Health
- Consumer Behavior and Market Dynamics
- Nutrition and Health Studies
MedAustron
2012-2024
Medical University of Warsaw
2019-2024
Medical University of Vienna
2012-2015
Vienna General Hospital
2014
Jan Długosz University
2013
Comprehensive Cancer Center Vienna
2013
<h2>Abstract</h2><h3>Introduction</h3> : Intracerebral radiation-induced contrast enhancement (RICE) can occur after photon as well proton beam therapy (PBT). This study evaluated the incidence, characteristics and risk factors of RICE PBT delivered to, or in direct proximity brain its impact on health-related quality life (HRQoL). <h3>Material Method</h3> Four hundred twenty-one patients treated by pencil beam-scanning between 2017 2021 were included. Follow-up included clinical evaluation...
Abstract Purpose Carbon ion radiotherapy (CIRT) relies on relative biological effectiveness (RBE)‐weighted dose calculations. Japanese clinics predominantly use the microdosimetric kinetic model (MKM), while European centers utilize local effect (LEM). Despite both models estimating RBE‐distributions in tissue, their physical and mathematical assumptions differ, leading to significant disparities RBE‐weighted doses. Several adopted treatment schedules, necessitating adjustments prescriptions...
Anatomical changes in the head-and-neck (H&N) region during course of treatment can cause deteriorated dose distributions. Different replanning strategies were investigated for volumetric modulated arc therapy (VMAT) and intensity-modulated proton (IMPT).
Patients undergoing radiotherapy will inevitably show anatomical changes during the course of treatment. These can be weight loss, tumour shrinkage, and organ motion or filling changes. For advanced adaptive (ART) information about must extracted from repeated images in order to able evaluate manage these Deformable image registration (DIR) is a tool that used efficiently gather The aim present study was performance two DIR methods for automatic at risk (OAR) contour propagation. Datasets...
To improve outcomes in large sarcomas/chordomas treated with CIRT, there has been recent interest LET optimization. We evaluated 22 pelvic sarcoma/chordoma patients CIRT [large: HD-CTV ≥ 250 cm
We present the early results of a novel partial bulky-tumor irradiation using particles for patients with recurrent unresectable bulky tumors who failed previous state-of-the-art treatments.First, eleven consecutive were treated from March 2020 until December 2021. The targeted Bystander Tumor Volume (BTV) was created by subtracting 1 cm Gross (GTV) surface. It reflected approximately 30% central GTV volume and irradiated 30-45 Gy RBE (Relative Biological Effectiveness) in three fractions....
Abstract Background Large tumor size has been reported as a predicting factor for inferior clinical outcome in carbon ion radiotherapy (CIRT). Besides the factors accompanied with such tumors, larger tumors receive typically more low linear energy transfer (LET) contributions than small ones which may be underlying physical cause. Although dose averaged LET is often used single parameter descriptor to quantify beam quality, there no evidence that this optimal predictor complex mixed...
Dose constraints are of paramount importance for the outcome any radiotherapy treatment. In this article, we report dose-volume as well currently used fractionation schedules carbon ion applied in MedAustron (Wiener Neustadt, Austria).
The increasing number of studies dealing with linear energy transfer (LET)-based evaluation and optimization in the field carbon ion radiotherapy (CIRT) indicates rising demand for LET implementation commercial treatment planning systems (TPS). Benchmarking could play a key role detecting (and thus preventing) computation errors prior implementing such functionalities TPS.This silico study was conducted to benchmark following two LET-related TPS against Monte Carlo simulations: (1) dose...
To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were using Local Effect Model-I (LEM-I), prescribed DRBE|LEM-I|D50% (median dose to HD-PTV) = 73.6 (70.4–76.8) Gy (RBE)/16 fractions. Sacral nerves contoured between L5-S3 levels. DRBE|LEM-I 5% of sacral nerves-to-spare (outside HD-CTV) (DRBE|LEM-I|D5%) restricted <69 (RBE). The median...
Carbon ion beams are well accepted as densely ionizing radiation with a high linear energy transfer (LET). However, the current clinical practice does not fully exploit highest possible dose-averaged LET (LET
Preand probiotics may help restore a dysbiotic oral ecosystem. The first years of life provide window opportunity to modulate the composition microbiota and prevent disease.
Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these is limited. This study analyzed from the EPICOVIDEHA-EPIFLUEHA registry, focusing HM diagnosed during 2023-2024 autumn-winter season. The assessed epidemiology, clinical characteristics, risk factors, outcomes. examined 1312 Of these, 59.5% required hospitalization, 13.5%...
To evaluate the use of formocresol (FC) and ferric sulfate (FS) as pulpotomy agents in vital pulp therapy (VPT) primary molars by dental practitioners.One hundred seventy-nine patients (aged 74.09 ± 20.75 months) who underwent were enrolled. The dmft, number visits, filling materials, clinical radiological observations complications evaluated.The data analysed using chi-square, Spearman's rank correlation odds ratio.The analysis included documentation 179 with 276 pulpotomies: 50 226 (FC)....