A5066445964- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- Social and Economic Solidarity
- Lipoproteins and Cardiovascular Health
- Sphingolipid Metabolism and Signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Social and Political Issues
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
Hospital de Santa Cruz
2021
BackgroundLocalized stress and cell death in chronic inflammatory diseases may release tissue-specific lipids into the circulation causing blood plasma lipidome to reflect type of inflammation. However, deep lipid profiles major have not been compared.MethodsPlasma lipidomes patients suffering from two etiologically distinct diseases, atherosclerosis-related vascular disease, including cardiovascular (CVD) ischemic stroke (IS), systemic lupus erythematosus (SLE), were screened by a top-down...
ABSTRACT OBJECTIVE A key event in atherogenesis is the formation of lipid-loaded macrophages, lipidotic cells, which exhibit irreversible accumulation undigested modified low-density lipoproteins lysosomes. This culminates with loss cell homeostasis, inflammation and death. In this study we propose to identify chemical etiological factors understanding molecular cellular mechanisms responsible for impairment lysosome function macrophages. APPROACH AND RESULTS Using shotgun lipidomics have...
Abstract Background Inflammation impacts several acute and chronic diseases causing localized stress cell death, releasing tissue-specific lipids into the circulation from inflamed cells tissues. The plasma lipidome may be expected to reflect type of inflammation specific tissues involved. However, deep lipid profiles major inflammatory have not been compared. Methods We compare lipidomes patients suffering two etiologically distinct diseases, atherosclerosis-related cardiovascular disease...