A5034665632- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Multiple and Secondary Primary Cancers
- Genital Health and Disease
- BRCA gene mutations in cancer
- Ultrasound and Hyperthermia Applications
- PARP inhibition in cancer therapy
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Sex and Gender in Healthcare
- Estrogen and related hormone effects
- Glutathione Transferases and Polymorphisms
- Uterine Myomas and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer survivorship and care
- Reproductive tract infections research
- Family Support in Illness
- Fungal Infections and Studies
- Molecular Biology Techniques and Applications
- Herpesvirus Infections and Treatments
- Endometriosis Research and Treatment
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
Tomsk National Research Medical Center
2014-2024
Russian Academy of Sciences
2018-2024
National Research Tomsk State University
2021
Tomsk Cancer Research Institute
2016-2020
Academy of Medical Sciences
2014
Определение стадии опухолевого процесса является важнейшим этапом в лечении пациенток со злокачественными заболеваниями, напрямую коррелирует с прогнозом и выбором специализированного лечения, облегчая при этом обмен информацией между медицинскими специалистами. Система стадирования должна обладать тремя основными характеристиками: она быть действенной, надежной практичной. Существующая система (классификации) рака эндометрия разработана 2009 г., высоковоспроизводимой не требует чрезмерных...
To evaluate the relapse-free and overall survival of HPV-positive patients with regard to physical status type 16 HPV HPV-negative primary CC. As a main result study predictive value was determined for Episomal form virus is favorable factor. Integrated severely unfavorable factor such significantly lower, than HPV- mixed virus. The results research are data on CC depending (for HPV+ patients) cancer.
The study involved 500 patients with LSIL (low grade squamous intraepithelial lesion), HSIL (high stage I-IV cervical cancer, infected human papillomavirus (HPV), as well 235 women without pathological changes in mucosa. comprehensive survey included colposcopy, cytological and histological analysis, detection genotyping of high-risk papillomavirus. Viral load physical status HPV16 DNA was evaluated cases mono-infection (n = 148). prevalence virus-positive among the LSIL/NSIL, cancer healthy...
Background. The age-standardized cervical cancer incidence rate in the Tomsk region 2021 was consistently higher than average for Russian Federation (21.2 / 100,000 versus 13.6 women). Primary prevention of is best achieved by human papillomavirus (HPV) vaccination girls. Aim. To evaluate HPV vaccine efficacy within framework implementation two regional programs: “Prevention gynecological and rehabilitation women diagnosed with 2008–2010” “Urgent measures to improve care population...
The study included 168 patients with precancerous cervical lesions 37 low-grade squamous intraepithelial (LSIL), 131 high-grade (HSIL), and 150 women, who had not abnormal cell changes. All underwent full colposcopy assessment, cytological/histological examination, molecular detection genotyping of high-risk human papillomavirus. Viral load physical status HPV-16 DNA was evaluated in cases mono-infection (n=208). prevalence virus-positive among the LSIL/NSIL healthy women 78.5 50.7 %,...
Due to improvements in short- and long-term clinical outcomes a study of quality life is one the most promising trends oncology today. This review analyzes published literature on problems dealing with patients gynecological cancer. Data respect extent anticancer treatment as well psychological social aspects are presented. The relationship between survival has been estimated.
Background . Determination of the feasibility performing minimally invasive surgery for cervical cancer and identification criteria optimal surgical access that ensures safety, effectiveness, satisfactory immediate long-term results remain challenging in gynecological oncology. The aim study was to evaluate treatment outcomes patients with who underwent radical hysterectomy via laparotomy compared those surgery. Material methods Treatment 91 carvical were analyzed. assessment objective tumor...
Background. The inclusion of lenvatinib in the immunotherapy regimen for patients with MSS/pMMR endometrial cancer (EC) is due to its ability modulate tumor microenvironment, which allows use pembrolizumab low-immunogenic tumors. However, only 30 % advanced or metastatic EC have a clinical response when treated and lenvatinib. In this regard, there an obvious need identify biomarkers that allow accurate selection candidates type therapy. Aim. To determine predictive value subpopulations...
This paper presents an intelligent model based on the Pix2Pix conditional generative adversarial network that automates process of predicting recurrence cervical malignancy in patients who have not yet undergone surgery. The implemented accepts a pelvic MRI image as input data and provides output probability tumor generated for "post-operative" perspective. presented differs from its basic analogue by modifying loss function problem conditions replacing standard generator with convolutional...
Background . Endometrial cancer (EC) is one of the most significant oncogynecological problems. The main mortality cause in this disease, as case other malignant neoplasms, tumor progression. presence mutations associated with mismatch repair-deficient great prognostic importance. Immunotargeting therapy (ITT), lenvatinib combination pembrolizumab, seems to be effective solution second line treatment advanced EC without microsatellite instability. At same time, group such patients...
Background . Ovarian cancer is the third most common of female reproductive system after cervical and uterine diagnosed at stage III–IV in 2 out 3 cases. Maintenance therapy with PARP inhibitors signifcantly prolongs disease-free overall survival. The purpose study was to demonstrate long-term remission a patient advanced ovarian using maintenance (olaparib). Description clinical case A 54-year-old verifed IV cancer, peritoneal carcinomatosis left-sided pleurisy received combined modality...
Cervical cancer is the second most common after breast and third cause of cancer-related death followed by lung cancers among women worldwide. advances in diagnostic imaging techniques provide better assessment regional distant cervical metastasis. use contrast-enhanced ultrasound a revolutionary modality; it has several advantages over ct: no radiation exposure, nephrotoxicity, obtaining real-time information, relatively low cost ease use. currently, contrast agent sonoVue widely used...
Background. Endometrial cancer is the most common malignancy of female reproductive system. Patients with metastatic endometrial have overall 5-year survival rate less than 20 %. The efficacy treatment advanced remains low; therefore, search for novel approaches treating great importance. Case description . We report a case 68-year-old who presented lesions found in axillary and lumbar lymph nodes, liver lungs. disease progressed after third-line chemotherapy, no deficiency DNA repair...
The important role of human papillomavirus (HPV) high carcinogenic risk in the emergence and development cervical cancer is undeniable. Approximately 90 % cases verified are HPV positive. level infection with this virus exceeds that gonococci, chlamydia yeast infections. Currently, one most discussed issues possibility association developing malignant neoplasms when localized organs anatomically close to cervix. One these localizations body uterus. It known endometrial based on its...
Visualization of sentinel lymph nodes (SLN) is now widely accepted for node (LN) detection using a radioactive lymphotropic trace. Preoperative lymphoscintigraphy with intraoperative lymphatic mapping under gamma detecting probe guidance proved to be an easy and reliable method SLN detection. Material methods. In this article we present our experience in laparoscopic gamma-probe visualization gynecological cancer. Results. Intraoperative young cervical cancer patients stage I endometrial...
Currently, studies highlighting features of emergence, development, clinical score and prognosis for patients with HPV-negative cervical cancer are scarce. However, the data regarding high recurrence rate mortality in head neck demonstrated. Here, canal exocervical scraping samples collected from 116 primary cancer, I–IV stages, aged 24 to 79 years, were examined real-time PCR assay assessing prevalence 12 oncogenic risk human papillomavirus (HPV) strains, genotyping viral load. It was found...
This review estimates immunohistochemical parameters reflecting apoptotic, proliferative activities, participating in angiogenesis and defining biological behavior of the tumor because treatment outcomes locally advanced cervical cancer remain poor. Disease recurrences occur within first two years after half patients. At same time, many issues concerning role various indices growth as prognostic factors are controversial. Therefore, study histological patterns molecular-biological...
The increased expression levels of Ki67, cyclooxygenase-2 (COX-2) and p16ink4a proteins after neoadjuvant chemotherapy for locally advanced cervical cancer were shown to correlate with unfavorable prognosis. level Ki67 before treatment was 85 % in patients, who subsequently developed disease progression. overall 5-year survival rates significantly higher patients <50 than >50 %. We found the correlation between COX-2 cancer. Thus, 84 66% expressions %, respectively. disease-free found.