A5028646292- Colorectal Cancer Surgical Treatments
- Advanced Neuroimaging Techniques and Applications
- Colorectal and Anal Carcinomas
- MRI in cancer diagnosis
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Ultrasound and Hyperthermia Applications
- MicroRNA in disease regulation
- Healthcare Systems and Public Health
- Long-Term Effects of COVID-19
- Endometrial and Cervical Cancer Treatments
- Diverticular Disease and Complications
- Extracellular vesicles in disease
- RNA regulation and disease
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Colorectal Cancer Screening and Detection
- COVID-19 and Mental Health
- Neurogenesis and neuroplasticity mechanisms
- RNA modifications and cancer
- Multiple and Secondary Primary Cancers
- Circular RNAs in diseases
- Radiopharmaceutical Chemistry and Applications
Tomsk National Research Medical Center
2019-2025
Russian Academy of Sciences
2019-2025
National Research Tomsk State University
2016-2024
Novosibirsk State Medical University
2020-2022
Ministry of Health of the Russian Federation
2020
Tomsk Cancer Research Institute
2016
Background . Treatment of patients with locally advanced pelvic cancer remains challenging. The use modern surgical techniques has expanded the feasibilities performing multivisceral resections (MVR) in this category patients. However, postoperative period who have undergone MVR is associated a high risk developing complications. purpose study was to assess short-term and long-term treatment outcomes multiple-primary cancer. Material Methods From 2009 2021, 114 treated clinics Cancer...
Abstract Myelin deficiency is commonly recognized as an important pathological feature of brain tissues in schizophrenia (SZ). In this pilot study, global myelin content abnormalities white matter (WM) and gray (GM) SZ patients were non-invasively investigated using a novel clinically-targeted quantitative imaging technique, fast macromolecular proton fraction (MPF) mapping. MPF maps obtained from 23 healthy subjects 31 clinical 1.5T magnetic resonance (MRI) scanner. Mean WM GM was compared...
Background: Depression is one of the most severe sequelae COVID-19, with major depressive disorder often characterized by disruption in white matter (WM) connectivity stemming from changes brain myelination. This study aimed to quantitatively assess myelination clinically diagnosed post-COVID depression (PCD) using recently proposed MRI method, macromolecular proton fraction (MPF) mapping. Methods: The involved 63 recovered COVID-19 patients (52 mild, 11 moderate, and 2 severe) at 13.5 ±...
Age-related myelination decrease is considered one of the likely mechanisms cognitive decline. The present study based on longitudinal assessment global and regional normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities FLAIR-MRI levels anti-myelin autoantibodies serum. Eleven healthy subjects (33–60 years first study) scanned twice, 7 apart. An MPF was found WM, GM, mixed WM-GM, as well 48...
Depression is one of the most severe sequelae COVID-19, with major depressive disorder often characterized by disruption in white matter (WM) connectivity , stemming from changes brain myelination. This study aimed to quantitatively assess myelination clinically diagnosed post-COVID depression using recently proposed MRI method, macromolecular proton fraction (MPF) mapping. The involved 63 recovered COVID-19 patients (52 mild, 11 moderate, 2 severe) at 13.5±10.0 months post-recovery, matched...
Age-related myelination decrease is considered one of the likely mechanisms cognitive decline. The present preliminary study based on longitudinal assessment global and regional normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities FLAIR-MRI levels anti-myelin autoantibodies serum. Eleven healthy subjects (33–60 years first study) scanned twice, seven apart. An MPF was found WM, grey (GM),...
Страница 99 МРТ В ДИАГНОСТИКЕ ОСТРОЙ ЛУЧЕВОЙ РЕАКЦИИ У БОЛЬНОЙ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫСтарцева Ж.А., Усова А.В., Фролова И
A clinical case with acute radiation reaction of the left breast after organ-preserving surgery 10 Gy IORT (24.8 Gy) conventional therapy has been presented. Comprehensive MRI examination showed signs radiation- induced damage to skin, soft tissues and vessels residual breast.
Background: Overweight and especially obesity are associated with the risk of development progression colorectal cancer. It can be assumed that there multifaceted interactions between tumor adipose tissue during anti-tumor treatment. Cancer cells secrete exosomes, extracellular vesicles affecting microenvironment promoting its or regression. The presence transcription/translation/folding factors (heat shock proteins (HSPs), matrix metalloproteinases (MMPs) their inhibitors (TIMPs) in...
Background: The fundamental question of normal brain myelination in human is still poorly understood. Methods: Age-dependent global, regional, and interhemispheric sex-related differences 42 (19 men, 23 women) healthy adults (19–67 years) were explored using the MRI method fast macromolecular fraction (MPF) mapping. Results: Higher males compared to females was found global white matter (WM), most WM tracts, juxtacortical regions, putamen. largest between men women, exceeding 4%, observed...
The majority of colorectal cancer patients (CRCPs) develop tumors on the background “metabolically healthy obesity” or metabolic syndrome. aim work was to study levels matrix metalloproteinases (MMPs) and heat shock proteins (HSPs) surface blood plasma CD9-positive FABP4-positive small extracellular vesicles (sEVs) from CRCPs depending status tumor angiogenesis, as well evaluate sEVs markers predictors effectiveness thermoradiotherapy. In CRCPs, compared with polyps (CPPs), proportion triple...
The purpose of the study was to develop and evaluate technique for volumetric tumor segmentation based on diffusion-weighted magnetic resonance imaging (DW-MRI) in predicting assessing response chemotherapy patients with bladder cancer (BC). Material Methods . We examined 26 morphologically verified transitional cell carcinoma bladder. group characterized by presence one or several tumors a size 17 46 mm. Before planning according M-VAC scheme, post-processing DW-MRI lesions, assessment...
Cervical cancer is the second most common after breast and third cause of cancer-related death followed by lung cancers among women worldwide. advances in diagnostic imaging techniques provide better assessment regional distant cervical metastasis. use contrast-enhanced ultrasound a revolutionary modality; it has several advantages over ct: no radiation exposure, nephrotoxicity, obtaining real-time information, relatively low cost ease use. currently, contrast agent sonoVue widely used...
The objective is to study the treatment results of patients with low rectal cancer complete tumor regression after neoadjuvant chemoradiation (CRT) and consolidating chemotherapy. Materials methods. investigation involved 70 adenocarcinoma stage mrT2-3N0-1M0 who were treated from 2013 till 2018. All these given in standard long-course fractionated radiation 2.0 Gy per day, total dose 45 Capecitabine daily 825 mg / m2 days radiation. If clinical morphological was registered 6 weeks completion...
Purpose was the assessment of diagnostic efficiency MR-rectography in diagnostics small-size rectal neoplasms. 12 patients with polyps and small tumors a rectum are examined, size detected neoplasms varied range 3-18 mm. Native MRI retrograde contrasting by ultrasonic gel carried out. Results compared results videocolonoscopy. Sensitivity native MRT 24%, MR- rectography 88%. can be used
Background. Currently, the indications for multivisceral pelvic resections have increased dramatically. However, short-and long-term outcomes after these locally advanced rectal cancer remain a subject of debate. The purpose study was to evaluate short-term surgical and oncological in patients with cancer. Material methods . We analyzed 32 (13 men 19 women) aged 44-69 years, cancer, who were treated between 2010 2016. Of patients, 28 (87.5 %) had invasion into adjacent organs (posterior wall...
This scientific review assesses the current diagnostic capabilities of diffusion-weighted images used in magnetic resonance imaging protocol for bladder cancer. It actualizes this impulse sequence employed within framework a multiparametric MRI study as one functional techniques. The deals with possibilities an independent version and combination T2-weighted to visualize tumor, postoperative changes, associated pathology. gives differential criteria identifying extent tumor invasion,...
Objective: Assessing short-term and long-term results of multivisceral resections (MVR) performed for rectal cancer (RC) with invasion into adjacent pelvic organs, as well the effectiveness bladder reconstruction formation a urinary reservoir «low» pressure. Methods: The work was based on surgical treatment 37 patients locally advanced or primary multiple RC underwent MVR. Invasion small organs observed in 89.2%, malignant tumors (PMMT) – 10.8% included study. Results: According to...
The purpose of the study: to analyze short-term efficacy and tolerability preoperative chemotherapy in patients with upper ampullary rectal carcinoma. Material methods. A prospective study conducted at cancer research institute (tomsk, russia) between 2018 2020 included 47 operable part rectum mrt3n0m0 (mesorectal fascia involvement (crm+) or low-grade cancer), mrt4аn0m0 mrt3–4аn1m0. All were divided into two groups. Group i comprised 22 patients, who received 3 cycles folfox-4 followed by...
Experiment of use MRI in diagnostics rectovaginal fistulas after combination therapy rectal cancer is shown on clinical examples. We used retrograde contrasting a rectum with 150ml ultrasonic gel to make more informative case low diagnostic efficiency ultrasound, colonoscopy and gynecological examination.