A5105979257- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Microbial metabolism and enzyme function
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Alcohol Consumption and Health Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Insect Utilization and Effects
- Neonatal Health and Biochemistry
- Protein Hydrolysis and Bioactive Peptides
- Healthcare and Venom Research
Centro de Ingeniería Genética y Biotecnología
2024
International Centre for Genetic Engineering and Biotechnology
2023-2024
Academy of Scientific and Innovative Research
2023
North East Institute of Science and Technology
2023
Background: Diagnosing sepsis in preterm neonates is a significant challenge, underscoring the urgent need for timely and accurate methods. Serum inflammatory protein signatures show promising potential early precise disease diagnosis. Methods: In this study, cohort of (n=50, 25-35 weeks gestation, female 40%) at time suspicion follow-up were enrolled along with healthy neonates. Based on clinical presentation blood culture or MALDI results, cases categorized into culture-positive...
Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bidirectional interactions between gut made dysbiotic microbiome one of the key factors NAFLD. In this study, we reported increased abundance Collinsella aerofaciens in obese NASH patients living India. We isolated C. from fecal samples biopsy-proven observed that their genome enriched with carbohydrate metabolism, acid biosynthesis, pro-inflammatory...
ABSTRACT Background Sepsis, a life-threatening disorder with multi-organ dysfunction, is leading cause of neonatal mortality. Current microbiology-based sepsis diagnosis time-consuming, and identification deregulated host serum metabolite signatures might be useful to develop early screening tools host-directed therapeutics. Methods In this multi-institutional study, 500 neonates (41.2% female) were classified culture-positive (CP) or negative (CN) cases controls (no sepsis: NS, healthy...
<title>Abstract</title> Better diagnostic biosignature is essential for neonatal sepsis. In this report, we identified a serum metabolite signature sepsis cases by mass spectrometry-based profiling of samples from two discovery cohorts (set-I/-II: n=71/269) patients (culture positive or negative:CP/CN) and controls (healthy:HC, no-sepsis:NS) validated in an independent cross-sectional (n=60) longitudinal cohort (n=100). The AUC ROC the six...
Abstract Dietary intake of antioxidant and anti-inflammatory-rich foods is a growing approach for fighting inflammation its associated disorders. Edible insects are gaining popularity as food source; however, their therapeutic properties, anti-inflammatory activity mechanism action remain largely unexplored. Herein, we evaluate the effectiveness Antheraea assamensis pupae hydrolysates against oxidative stress inflammation. The proteins isolated from were digested with pepsin or pancreatin, +...