A5040564075- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Trypanosoma species research and implications
- HIV Research and Treatment
- Biochemical and Molecular Research
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- HIV/AIDS drug development and treatment
Brown University
2017-2021
John Brown University
2020
University of Massachusetts Amherst
2018
Abstract EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate regulate largely distinct gene sets during this process. is dominantly expressed in immature NK cells drives early lineage specification by inducing hallmark receptors functions. By contrast, dominant mature cells, where it induces responsiveness to IL-12 represses the cycle, likely through transcriptional repressors. Regardless, many genes with functions...
The liver harbors two main innate lymphoid cell (ILC) populations: conventional NK (cNK) cells and tissue-resident (trNK) cells. Using the MCMV model of infection, we find that, in contrast to cNK cells, trNK initially undergo a contraction phase followed by recovery homeostatic levels. is independent because similar phenotype observed following poly(I:C)/CpG or α-GalCer injection. rapid due apoptosis, whereas occurs via proliferation situ. Interestingly, apoptosis not mediated fratricide...
Checkpoint blockade therapy is effective against many cancers; however, new targets need to be identified treat patients who do not respond current treatment or demonstrate immune escape. Here, we showed that blocking the inhibitory receptor Killer cell lectin-like G1 (KLRG1) enhances anti-tumor immunity mediated by NK cells and CD8+ T cells. We found loss of KLRG1 signaling alone significantly decreased melanoma breast cancer tumor growth in lungs mice. In addition, demonstrated can...
Abstract DNA replication, transcription and chromatin remodeling are coordinated to ensure accurate duplication of genetic epigenetic information. In regard trypanosomatid parasites such as Trypanosoma brucei display unusual properties including significantly fewer origins replication than model eukaryotes, a highly divergent Origin Replication Complex (ORC), an apparent lack several factor homologs. Although recent studies in T. indicate functional links among transcription, antigenic...
Abstract The liver harbors two main innate lymphoid cell (ILC) populations, conventional NK (cNK) cells and tissue-resident (trNK) also called ILC1s. While the antiviral functions of cNK have been well established, trNK are only beginning to be uncovered. Using MCMV model infection, we found that in contrast cells, population initially undergoes a contraction phase prior recovery homeostatic levels. rapid is due apoptosis, while occurs via proliferation situ. Liver apoptosis not mediated by...
Abstract Natural Killer (NK) cells belong to the ILC1 subgroup, which contains conventional NK (cNK) cells, and tissue-resident (trNK) cells. The murine liver is home both cNK trNK In this organ, can be distinguished based on expression of transcription factors Eomes T-bet. are double positive for T-bet while do not express Eomes. During viral infection, fate activated cell population relatively well defined. However, remains unexplored. Using MCMV model we found that a contraction phase...
Abstract The presence of tissue-resident NK (trNK) cells in the liver has only recently been appreciated. While role conventional (cNK) well-characterized, trNK cell function is beginning to be elucidated. Using MCMV model infection, we found that contrast cNK cells, initially undergo a contraction phase followed by recovery homeostatic levels. independent virus itself as similar phenotype observed following Poly I:C/CpG or α-GalCer injection. Interestingly, this initial other lymphocyte...
Abstract Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) regulates cellular apoptosis and inflammation, growing evidence indicates a key role in antiviral defense. Cytomegalovirus (CMV, b-herpesvirus) establishes lifelong persistent/latent infection that depends upon viral subversion of host innate adaptive defenses. We have shown both human mouse CMV inhibit signaling by the TRAIL death receptors (DR) through use specific proteins. MCMV m166 blocks TRAIL-DR expression...