A5086690547- Obesity, Physical Activity, Diet
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Nutritional Studies and Diet
- Psoriasis: Treatment and Pathogenesis
- Multiple Sclerosis Research Studies
- Lysosomal Storage Disorders Research
- Health Promotion and Cardiovascular Prevention
- Diet and metabolism studies
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- Influenza Virus Research Studies
- Health disparities and outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory viral infections research
- Body Composition Measurement Techniques
- Diet, Metabolism, and Disease
- Parasites and Host Interactions
- Vaccine Coverage and Hesitancy
- Trypanosoma species research and implications
Provincial Health Services Authority
2024
BC Centre for Disease Control
2021-2023
Imperial Consultants
2020-2022
University of Alberta
2015-2019
University of British Columbia
2018-2019
University of Saskatchewan
2012-2015
Saskatoon Medical Imaging
2014
The Canadian coronavirus disease 2019 (COVID-19) immunization strategy deferred second doses and allowed mixed schedules. We compared 2-dose vaccine effectiveness (VE) by type (mRNA and/or ChAdOx1), interval between doses, time since dose in 2 of Canada's larger provinces.
ABSTRACT Background The Canadian COVID-19 immunization strategy deferred second doses and allowed mixed schedules. We compared two-dose vaccine effectiveness (VE) by type (mRNA and/or ChAdOx1), interval between doses, time since dose in two of Canada’s larger provinces. Methods Two-dose VE against infections hospitalizations due to SARS-CoV-2, including variants concern, was assessed May 30 October 2, 2021 using test-negative designs separately conducted among community-dwelling adults...
Randomized-controlled trials of messenger RNA (mRNA) vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) included relatively few elderly participants. We assess single-dose mRNA effectiveness (VE) in adults ≥ 70 years old British Columbia, Canada, where second doses were deferred by up to 16 weeks and a spring 2021 wave uniquely codominant circulation Alpha (B.1.1.7) Gamma (P.1) variants concern (VOC).
The British Columbia COVID-19 Cohort (BCC19C) was developed from an innovative, dynamic surveillance platform and is accessed/analyzed through a cloud-based environment. integrates recently provincial datasets (refreshed daily) with existing administrative holdings registries weekly/monthly). platform/cohort were established to inform the response in near "real-time" answer more in-depth epidemiologic questions.
Introduction We compared the population rate of COVID-19 and influenza hospitalisations by age, vaccine status pandemic phase, which was lacking in other studies. Method conducted a population-based study using hospital data from province British Columbia (population 5.3 million) Canada with universal healthcare coverage. created two cohorts based on date admission: annual cohort (March 2020 to February 2021) peak (Omicron era; first 10 weeks 2022). For comparison, we three historical...
Several studies have shown that a poor vitamin D status may increase the risk of developing metabolic syndrome, which leaves question whether improving one’s reduce for syndrome. Here we investigate effect temporal changes in serum 25-hydroxyvitamin (25(OH)D) concentrations on syndrome among Canadians enrolled preventive health program promotes supplementation. We accessed and analyzed data 6682 volunteer participants with repeated observations 25(OH)D applied logistic regression to quantify...
Public health decision makers not only consider benefits but also economic implications when articulating and issuing lifestyle recommendations. Whereas various estimates exist for the burden of physical inactivity, excess body weight smoking, associated with our diet are rare. In present study, we estimated attributable to inadequate consumption vegetables fruit in Canada.We accessed Canadian Community Health Survey assess inadequacy published meta-analyses assemble risk chronic diseases....
To quantify the association of dietary quality with prospective changes in adiposity.Children participating QUALITY (QUebec Adipose and Lifestyle InvesTigation Youth) study underwent examination at baseline 2-year follow-up. Dietary was assessed by Diet Quality Index-International (DQII) using three non-consecutive 24 h diet recalls baseline. The DQII has four main categories: adequacy, variety, moderation overall balance. Fat mass index (FMI; [fat (kg)]/[height (m)]2), central FMI (CFMI;...
The Alberta Project Promoting active Living and healthy Eating in Schools (APPLE Schools) has been recognized as a "best practice" preventing childhood obesity. To inform decision making on the economic implications of APPLE to justify investment, we evaluated project's cost-effectiveness following life-course approach.We developed state transition model for lifetime progression body weight status comparing elementary school students attending control schools. This quantified impact terms...
Background. Metabolic syndrome (MetS) includes five chronic disease risk factors which doubles the of CVD and increases diabetes fivefold. Objective. To determine prevalence MetS its in Canadians (12–79 y) to compare dietary intake with without MetS. Subjects Methods. Cycle 1 Canadian health measures survey, CHMS data, 2007–2009, was used. identify cases, most recent criteria were used for adults adolescents. Ethnical cut points waist measurement applied adults. Results Conclusion. The among...
Only few studies examined the effect of diet on prospective changes in cardiometabolic (CM) risk factors children and youth despite its importance for understanding role early life cardiovascular disease adulthood. To test hypothesis that dietary intake is associated with CM factors, we analyzed longitudinal observations made over a period 2 years among 448 students (aged 10-17 years) from 14 schools Canada. We applied mixed regression to examine associations at baseline body mass index,...
Background . Cardiovascular disease (CVD) is the leading cause of death in adult Canadians. Cardiometabolic risk (CMR) derived from 10-year cardiovascular diseases and metabolic syndrome (MetS) needs to be evaluated Canadian adults. Objective To determine CMR among adults by sociodemographic lifestyle characteristics. Subjects Methods Data Health Measures Survey (CHMS), Cycle 1, 2007–2009, was used. Framingham Risk Score (FRS) implemented predict CVD, identified using most recent criteria....
In British Columbia, Canada, most adults 50-69 years old became eligible for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in April 2021, with chimpanzee adenoviral vectored (ChAdOx1) restricted to ≥55-year-olds and second doses deferred ≥6 weeks optimize single-dose coverage.Among old, messenger RNA (mRNA) ChAdOx1 effectiveness (VE) against SARS-CoV-2 infection hospitalization, including variant-specific, was assessed by test-negative design between 4 October...
To identify which anthropometric measurement would be the best predictor of metabolic syndrome (MetS) in Brazilian adolescents.Cross-sectional study conducted on 222 adolescents (15-17 years) from a city southern Brazil. Anthropometric, physical activity, blood pressure and biochemical parameters were investigated. MetS criteria transformed into continuous variable (MetS score). Linear regression analyses performed to assess associations BMI, hip circumference, neck circumference (NC),...
Initial risk assessment to estimate 10-year of cardiovascular disease (CVD) is completed by Framingham Risk Score (FRS). In 2012 2 modifications were added FRS the Canadian Cardiovascular Society: doubled in subjects aged 30–59 years who have CVD present a first-degree relative before 55 age for men and 65 women; calculated each individual. Our aim was implement these evaluate differences compared with traditional FRS. Further, we evaluated association between dietary intake risk. The Health...
Mucopolysaccharidosis II (MPS II; Hunter syndrome) is a rare, X-linked, life-limiting lysosomal storage disease characterized by deficiency in the activity of enzyme iduronate-2-sulfatase. Accumulation glycosaminoglycans tissues and organs throughout body causes cellular damage, leading to multisystemic manifestations. Patients generally require multidisciplinary care across wide range specialties.
ABSTRACT Introduction Randomized-controlled trials of mRNA vaccine protection against SARS-CoV-2 included relatively few elderly participants. We assess singe-dose effectiveness (VE) in adults ≥70-years-old British Columbia (BC), Canada where the second dose was deferred by up to 16 weeks and a spring 2021 wave uniquely co-dominant circulation B.1.1.7 P.1 variants concern (VOC). Methods Analyses community-dwelling with specimen collection between April 4 (epidemiological week 14) May 1 (week...
ABSTRACT Introduction In randomized controlled trials, single-dose efficacy against SARS-CoV-2 illness exceeded 90% for mRNA vaccines (BNT162b2 and mRNA-1273), 75% ChAdOx1. British Columbia (BC), Canada second doses were deferred up to 16 weeks ChAdOx1 was only initially recommended adults 55 years of age older. We compared vaccine effectiveness (VE) during the spring 2021 wave in BC when Alpha Gamma variants concern (VOC) predominated. Methods VE estimated infection hospitalization by...
To assess treatment patterns of Ixekizumab (IXE) and evaluate the speed onset long-term clinical quality-of-life outcomes among a subset patients who switched from adalimumab (ADA) secukinumab (SEC) to IXE in real-world setting.A retrospective chart review study was conducted at single US dermatology referral center.153 were included study, 69.3% biologic-experienced. ADA most commonly used biologic prior initiation. 66.7% remained on end. 47.7% received concomitant methotrexate, usage...