A5072619089- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
- Liver Disease and Transplantation
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Liver Diseases and Immunity
- COVID-19 and Mental Health
- Hepatitis Viruses Studies and Epidemiology
- Opioid Use Disorder Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Digital Contact Tracing
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Data-Driven Disease Surveillance
- Viral-associated cancers and disorders
- Diabetes Management and Education
- HIV/AIDS Research and Interventions
University of British Columbia
2018-2024
BC Centre for Disease Control
2018-2024
Provincial Health Services Authority
2024
AstraZeneca (United States)
2024
European University of Tirana
2022
Ministry of Health
2018
Yale University
2013-2017
Icahn School of Medicine at Mount Sinai
2010-2013
Boston Children's Hospital
2009
Importance SARS-CoV-2 infection may lead to acute and chronic sequelae. Emerging evidence suggests a higher risk of diabetes after infection, but population-based is still sparse. Objective To evaluate the association between COVID-19 including severity diabetes. Design, Setting, Participants This cohort study was conducted in British Columbia, Canada, from January 1, 2020, December 31, 2021, using Columbia Cohort, surveillance platform that integrates data with registries administrative...
Abstract Background Population‐level monitoring of hepatitis C virus (HCV) infected people across cascades care identifies gaps in access and engagement treatment. We characterized the population‐level cascade for HCV British Columbia (BC), Canada before after introduction Direct Acting Antiviral (DAA) Methods BC Hepatitis Testers Cohort (BC‐HTC) includes 1.7 million individuals tested HCV, HIV, reported cases B, active tuberculosis from 1990 to 2018 linked medical visits, hospitalizations,...
The APOBEC3 family comprises seven cytidine deaminases (APOBEC3A [A3A] to A3H), which are expressed various degrees in HIV-1 susceptible cells. Vif protein counteracts restriction by mediating its degradation the proteasome. We hypothesized that proteins from subtypes differ their abilities counteract different proteins. Seventeen alleles were tested for degrade and A3G, A3F, A3H haplotype II (hapII). show most neutralize A3G A3F efficiently but display differences with respect inhibition of...
Background. Healthcare workers may come into contact with fomites that contain infectious hepatitis C virus (HCV) during preparation of plasma or following placement removal venous lines. Similarly, injection drugs users fomites. Hypothesizing prolonged viability HCV in contribute significantly to incidence, we determined the longevity infectivity and effectiveness antiseptics.
Abstract Objectives To quantify mortality rates for patients successfully treated hepatitis C in the era of interferon-free, direct acting antivirals and compare these with those general population. Design Population based cohort study. Setting British Columbia, Scotland, England (England consists cirrhosis only). Participants 21 790 people who were interferon-free (2014-19). divided into three liver disease severity groups: without (pre-cirrhosis), compensated cirrhosis, end stage disease....
The British Columbia COVID-19 Cohort (BCC19C) was developed from an innovative, dynamic surveillance platform and is accessed/analyzed through a cloud-based environment. integrates recently provincial datasets (refreshed daily) with existing administrative holdings registries weekly/monthly). platform/cohort were established to inform the response in near "real-time" answer more in-depth epidemiologic questions.
HIV-1 requires the cellular transcription factor CBFβ to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of allow for increased steady-state levels Vif, enhanced degradation, viral infectivity. This conserved functional interaction enhances proteins from multiple subtypes is required degradation all human rhesus Vif-sensitive APOBEC3 by their respective lentiviral proteins.
Abstract We evaluated the effect of sustained virologic response (SVR) from direct‐acting antiviral (DAA)‐ and interferon‐based treatments on hepatocellular carcinoma (HCC) risk in a large population‐based cohort Canada. used data BC Hepatitis Testers Cohort, which includes ~1.3 million individuals tested for HCV since 1990, linked with healthcare administrative registry datasets. Patients were followed end treatment to HCC, death or 31 December 2016. assessed HCC among those who did not...
Objectives We sought to 1) identify long COVID phenotypes based on patient reported outcome measures (PROMs) and 2) determine whether the were associated with quality of life (QoL) and/or lung function. Methods This was a longitudinal cohort study hospitalized non-hospitalized patients from March 2020 January 2022 that conducted across 4 Post-COVID Recovery Clinics in British Columbia, Canada. Latent class analysis used using baseline PROMs (fatigue, dyspnea, cough, anxiety, depression,...
We compared the seroprevalence of SARS-CoV-2 anti-nucleocapsid antibodies in blood donors across Canadian regions 2021. The was highest Alberta and Prairies, it so low Atlantic Canada that few correlates were observed. Being male young age predictive seropositivity. Racialization associated with higher British Columbia Ontario but not Prairies. Living a materially deprived neighborhood predicted seroprevalence, more linear quintiles whereas Ontario, most affluent 60% similarly 40% elevated....
Background: The HIV-1 Vif protein counteracts the antiviral activity of cytidine deaminases APOBEC3G and APOBEC3F. Natural variation in may result reduced efficacy against APOBEC3 proteins increased diversity. We speculated that this mechanism could facilitate viral escape from certain antiretroviral drugs. Methods results: analyzed protease, reverse transcriptase sequences viruses plasma obtained 92 HIV-1-infected individuals failing treatment 65 antiretroviral-naive patients. Mutation K22H...
Clinical trials show high efficacy of sofosbuvir/velpatasvir (SOF/VEL), but there are limited data from "real-world" settings. We aimed to evaluate SOF/VEL effectiveness for all hepatitis C virus (HCV) genotypes (GTs) in British Columbia (BC), Canada.We used the BC Hepatitis Testers Cohort, which includes HCV cases province (1990-2015) linked administrative databases, including prescriptions end 2018. measured sustained virologic response (SVR; negative RNA ≥10 weeks after treatment end) and...
Hepatitis B surveillance is essential to achieving Canada's goal of eliminating hepatitis by 2030. rates, association infection with vaccine age-eligibility, and risk factors were analyzed among 1,401,603 first-time Canadian blood donors from 2005 2020. Donors classified as having likely chronic or resolved/occult infections based on surface antigen, anti-hepatitis core nucleic acid test results. Likely chronically infected control (ratio 1:4) participated in risk-factor interviews. The 2019...
<h3>Importance</h3> Achievement of the World Health Organization (WHO) target eliminating hepatitis C virus (HCV) by 2030 will require an increase in key services, including harm reduction, HCV screening, and treatment initiatives member countries. These data are not available for Canada but important informing a national elimination strategy. <h3>Objective</h3> To use decision analytical model to explore association different strategies with epidemiology HCV-associated mortality assess...
Trypsin primes rotavirus for efficient infectivity by cleaving the spike protein, VP4, into VP8* and VP5*. A recombinant VP5* fragment has a trimeric, folded-back structure. Comparison of this structure with virion spikes suggests that rearrangement, analogous to those enveloped virus fusion proteins, may mediate membrane penetration during entry. To detect inferred rearrangement virion-associated authentic VP5*, we raised conformation-specific monoclonal antibodies against in its putative...
Some human APOBEC3 cytidine deaminases have antiviral activity against HIV-1 and other retroviruses. The single deaminase domain APOBEC3H (A3H) enzyme is highly polymorphic multiple A3H haplotypes been identified. haplotype II (A3H-hapII) possesses the strongest HIV-1. There remains, however, uncertainty regarding extent to which A3H-hapII sensitive Vif mediated degradation. We tested, therefore, two different reference proteins widely used in previous studies. show that resistant NL4-3...
Abstract Effectiveness of direct‐acting antiviral (DAA) therapies could be influenced by patient characteristics such as comorbid conditions, which lead to premature treatment discontinuation and/or irregular medical follow‐ups. Here, we evaluate loss follow‐up and effectiveness sofosbuvir/ledipasvir ± ribavirin (SOF/LDV RBV), ombitasvir/paritaprevir/ritonavir + dasabuvir (OBV/PTV/r DSV RBV) for hepatitis C virus (HCV) genotype 1 (GT1) sofosbuvir (SOF 3 (GT3) in British Columbia Canada: The...
Abstract Background & Aims Public health measures introduced to limit transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which causes disease 2019 (COVID‐19), also disrupted various healthcare services in many regions worldwide, including British Columbia (BC), Canada. We assessed the impact these measures, first BC March 2020, on hepatitis C (HCV) testing and first‐time HCV‐positive diagnoses within province. Methods De‐identified HCV data for residents were...
Long coronavirus disease (COVID) patients experience persistent symptoms after acute severe respiratory syndrome 2 (SARS-CoV-2) infection. Healthcare utilization data could provide critical information on the burden of long COVID for service planning; however, not all are diagnosed or assigned diagnostic codes. We developed an algorithm to identify individuals with using population-level health administrative from British Columbia (BC), Canada.An elastic net penalized logistic regression...
Abstract Background Hepatitis C virus (HCV), hepatitis B (HBV), and human immunodeficiency (HIV) infections are associated with significant mortality globally in North America. However, data on impact of concurrent multiple risk limited. We evaluated the effect HCV, HBV, HIV coinfections factors all-cause British Columbia (BC), Canada. Methods The BC Testers Cohort includes ~1.7 million individuals tested for HCV or HIV, reported as a case HBV from 1990 to 2015, linked administrative...
Evidence that opioid agonist therapy (OAT) is associated with increased odds of hepatitis C virus (HCV) treatment initiation among people who use drugs (PWUD) emerging. The objective this study was to determine the association between current OAT and HCV PWUD in a population-level linked administrative dataset.