J. J. Fragío Gil

ORCID: 0000-0003-3473-7927
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About
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Research Areas
  • Systemic Lupus Erythematosus Research
  • Rheumatoid Arthritis Research and Therapies
  • Systemic Sclerosis and Related Diseases
  • Infectious Diseases and Tuberculosis
  • Orthopedic Infections and Treatments
  • Hematological disorders and diagnostics
  • Inflammatory Myopathies and Dermatomyositis
  • Infective Endocarditis Diagnosis and Management
  • Autoimmune and Inflammatory Disorders Research
  • Neuroendocrine Tumor Research Advances
  • IgG4-Related and Inflammatory Diseases
  • Liver Diseases and Immunity
  • Atherosclerosis and Cardiovascular Diseases
  • Biosimilars and Bioanalytical Methods
  • Monoclonal and Polyclonal Antibodies Research
  • Immunodeficiency and Autoimmune Disorders
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Skin Diseases and Diabetes
  • Bone Metabolism and Diseases
  • Liver Disease Diagnosis and Treatment
  • Bone health and treatments
  • Ocular Diseases and Behçet’s Syndrome
  • Psoriasis: Treatment and Pathogenesis
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Gastrointestinal Bleeding Diagnosis and Treatment

Hospital Universitari i Politècnic La Fe
2020-2024

Hospital General Universitario De Valencia
2023-2024

Valencia Catholic University Saint Vincent Martyr
2021-2024

Instituto de Salud Musculoesquelética
2024

Leitat Technological Center
2020-2023

Instituto de Investigación Sanitaria La Fe
2018-2022

Universidad Autónoma del Caribe
2020

<h3>Objectives</h3> To assess the effectiveness and safety of baricitinib in treatment Rhupus. <h3>Methods</h3> We conducted a retrospective observational review medical records from Rheumatology Department at our hospital between 2019 2023, identifying patients diagnosed with Rhupus, who received baricitinib. The diagnosis Rhupus was assigned to met diagnostic criteria for both Rheumatoid Arthritis (RA) Systemic Lupus Erythematosus (SLE). study involves comprehensive analysis clinical...

10.1136/lupus-2024-el.211 article EN cc-by-nc Poster presentations 2024-03-01

<h3>Objectives</h3> To analyze the effectiveness and safety of Belimumab in SLE patients with data from a Real-World cohort. <h3>Methods</h3> A single center observational study was performed including who had initiated treatment September 2017 to January 2023. Demographic, clinical, laboratory, variables were collected. Effectiveness evaluated according changes baseline SLEDAI-2K disease activity markers (proteinuria, complement consumption and/or Anti DNAds). Safety collected any adverse...

10.1136/lupus-2024-el.212 article EN cc-by-nc Poster presentations 2024-03-01

Objective To develop an improved score for prediction of severe infection in patients with systemic lupus erythematosus (SLE), namely, the SLE Severe Infection Score-Revised (SLESIS-R) and to validate it a large multicentre cohort. Methods We used data from prospective phase RELESSER (RELESSER-PROS), register Spanish Society Rheumatology. A multivariable logistic model was constructed taking into account variables already forming SLESIS score, plus all other potential predictors identified...

10.1136/lupus-2023-001096 article EN cc-by-nc Lupus Science & Medicine 2024-04-01

<h3>Background</h3> Little is known about depression in SLE. To evaluate the prevalence of and associated factors a large, multicenter SLE cohort (RELESSER-PROS). <h3>Methods</h3> Prospective longitudinal study patients answering positively to question Lupus Impact Tracker (LIT) questionary (question number 7, LITQ7 'I was depressed') over 5 consecutive annual visits (V1 V5). Self-perceived answered from 0 ('none time') 4 ('most time'). Covariates with potential impact were considered....

10.1136/lupus-2023-kcr.247 article EN cc-by-nc 2023-07-01

<h3>Background:</h3> Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and cartilage destruction. In addition to its impact on musculoskeletal system, RA has been recognized as systemic associated with an increased risk of cardiovascular disease. Current CV screening management strategies underestimate the actual in RA. Thus, adequate stratification special relevance identify patients at <h3>Objectives:</h3> To evaluate profile assessing both...

10.1136/annrheumdis-2024-eular.5850 article EN Annals of the Rheumatic Diseases 2024-06-01

<h3>Background:</h3> Idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of systemic rheumatic diseases characterized by chronic muscle weakness and the infiltration mononuclear cells into tissue. The etiology is unknown; however, association between IIM neoplastic processes recognized, being more pronounced in dermatomyositis (DM) compared to polymyositis (PM). Nonetheless, nature extent this are not fully elucidated. <h3>Objectives:</h3> To analyze clinical phenotype...

10.1136/annrheumdis-2024-eular.2790 article EN Annals of the Rheumatic Diseases 2024-06-01

<h3>Background:</h3> Rheumatisms are the second most frequent reason for consultation in Europe [1]. In Spain, bulk of prevalence studies exploit public health data [2-3], despite fact that our system is mixed. Spanish private spending reaches 26.7% total and booming [4]. However, there a fundamental lack focused on care, which local [5-6]. <h3>Objectives:</h3> To characterise activity performed by rheumatologists medicine throughout geography. <h3>Methods:</h3> Members SERPA working group...

10.1136/annrheumdis-2024-eular.3402 article EN Annals of the Rheumatic Diseases 2024-06-01

<h3>Background:</h3> IgG4-related disease (IgG4-RD) is a rare, systemic, immunomediated fibroinflammatory process with uncertain etiology and pathophysiology that can affect multiple organs, presenting common clinical, radiological, serological characteristics. Although the associated IgG4, serum levels are not elevated in all patients; it has also been described other respiratory system diseases (bronchiectasis, asthma, sarcoidosis), pancreatic (chronic pancreatitis), liver (cirrhosis), or...

10.1136/annrheumdis-2024-eular.4415 article EN Annals of the Rheumatic Diseases 2024-06-01

<h3>Background:</h3> Systemic sclerosis (SSc) is an autoimmune disease of unknown etiology, characterized by fibrosis in the skin, vascular walls, and certain organs such as lungs, digestive tract, heart, or kidneys. The classically divided into limited (lcSSc) diffuse (dcSSc), according to, among other manifestations, extent cutaneous involvement. Within lcSSc, CREST syndrome described, which includes calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, telangiectasia....

10.1136/annrheumdis-2024-eular.6044 article EN Annals of the Rheumatic Diseases 2024-06-01

Rheumatoid arthritis (RA) increases the risk of premature mortality, primarily due to cardiovascular diseases (CVD). While Systematic Coronary Risk Evaluation (SCORE) and its updated version SCORE2 are used estimate CVD risk, these tools may not adequately capture full profile in RA patients.

10.1177/1759720x241302667 article EN cc-by-nc Therapeutic Advances in Musculoskeletal Disease 2024-01-01

We present the case of a 70 years old woman with infectious discitis which was detected using Fluorine fluodeoxiglucose positron emission tomography/computed tomography (18F-FDG PET/CT), after negative magnetic resonance imaging. A Streptococuss gallolyticus (bovis gender bacteria) grow on culture. In addition 18F-FDG PET also demonstrated endocarditis confirmed by transesophageal echocardiography and colonic neoplasm. Here we have highlighted potential role PET/CT study in patients clinical...

10.1016/j.radcr.2019.04.006 article EN cc-by-nc-nd Radiology Case Reports 2019-08-03

<h3>Background:</h3> Systemic lupus erythematosus (SLE) is an autoimmune chronic disease produced by aberrant immunological response that consequently, causes a widespread organic damage. Treatment leads to regulating this disrupted response. As result, in 2011 Belimumab was approved for adults patients diagnosed with SLE, what monoclonal human antibody whose target B-lymphocyte stimulator (BLyS), protein involved the pathogeny. <h3>Objectives:</h3> To evaluate glucocorticoesteroid dose...

10.1136/annrheumdis-2019-eular.6585 article EN Annals of the Rheumatic Diseases 2019-06-01

<h3>Background</h3> Antimalarials represent the cornerstone of SLE treatment, since its uses control clinical manifestations in many patients, prevents disease flare and permits steroid reduction. The aim this study is to describe safety profile reasons for discontinuation antimalarials patients with determine which factors act as a predictor drop-out. <h3>Methods</h3> A single centre, retrospective, case was performed including according SLICC 2012 criteria. Clinical demographical variables...

10.1136/lupus-2020-eurolupus.209 article EN Poster presentations 2020-03-01

<h3>Background:</h3> Pulmonary involvement is the main cause of death in Systemic Sclerosis patients (SS). However, there little information whether its presence capable affecting functional capacity and if this influences quality life perceived by them. <h3>Objectives:</h3> To determine pulmonary with SS (Interstitial Lung Disease or Arterial Hypertension) related to greater disability. <h3>Methods:</h3> Observational cross-sectional study, a prospectively performed protocol, diagnosed...

10.1136/annrheumdis-2019-eular.6576 article EN Annals of the Rheumatic Diseases 2019-06-01
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