A5033985506- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- COVID-19 and Mental Health
- Hemoglobinopathies and Related Disorders
- Vasculitis and related conditions
- Adolescent and Pediatric Healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Inflammasome and immune disorders
- Iron Metabolism and Disorders
- Human Health and Disease
- Emergency and Acute Care Studies
- Retinal and Optic Conditions
- Pharmacovigilance and Adverse Drug Reactions
- Atherosclerosis and Cardiovascular Diseases
- Tracheal and airway disorders
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmaceutical studies and practices
- Blood groups and transfusion
- Respiratory and Cough-Related Research
- Sleep and related disorders
- Childhood Cancer Survivors' Quality of Life
- Intestinal and Peritoneal Adhesions
- Circadian rhythm and melatonin
- Ocular Diseases and Behçet’s Syndrome
Assistance Publique – Hôpitaux de Paris
2022-2025
Inserm
2023-2025
Université Paris Cité
2022-2025
Sorbonne Paris Cité
2024-2025
Hôpital Robert-Debré
2022-2024
Centre d’Investigation Clinique 1436
2023-2024
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis, resulting in 3 million hospitalizations each year worldwide. Nirsevimab a monoclonal antibody against RSV that has an extended half-life. Its postlicensure real-world effectiveness RSV-associated bronchiolitis unclear.
Importance Henoch-Schönlein purpura (HSP) is the most common type of vasculitis in children. The factors that trigger disease are poorly understood. Although several viruses and seasonal bacterial infections have been associated with HSP, differentiating specific associations these pathogens onset HSP remains a challenge due to their overlapping patterns. Objective To analyze role epidemiology HSP. Design, Setting, Participants This cohort study comprised an interrupted time-series analysis...
Importance Numerous studies have provided evidence for the negative associations of COVID-19 pandemic with mental health, but data on use psychotropic medication in children and adolescents after onset are lacking. Objective To assess rates trends prescribing before over 2 years France. Design, Setting, Participants This cross-sectional study used nationwide interrupted time-series analysis outpatient drug dispensing from IQVIA X-ponent database. All 8 839 143 prescriptions dispensed to (6...
Kawasaki disease is an acute, febrile, systemic vasculitis of children that primarily affects medium-sized blood vessels with a tropism for the coronary arteries. Although etiological factors remain unknown, infections have been suggested as trigger disease. We sought to calculate fraction potentially attributable seasonal infections.This cohort study used population-based time series analysis from French hospitalisation database (Programme de Médicalisation des Systèmes d'Information),...
Following non-pharmaceutical interventions (NPI) lifting in 2021, an important surge childhood lower respiratory tract infections (LRTI) was reported several countries, raising major concerns about the middle-term consequences of such interventions. Whether this recent upsurge overwhelms initial benefit NPI remains unknown. We conducted interrupted time-series analysis based on exhaustive national surveillance systems. All hospitalisations from January 2015 to March 2023 and all ambulatory...
To assess rates and trends of hypnotic medication prescriptions for children adolescents. Cross-sectional study national dispensing data between January 1, 2016, December 31, 2023, in France. Prescriptions medications (hydroxyzine, alimemazine, melatonin, Z-drugs) dispensed to aged 6 17 years were analyzed. Monthly per 1,000 modeled before after the pandemic onset (March 2020) rate trend changes. Rate ratios (RR) calculated estimated expected prescription rates. Overall, 2,675,142 an average...
Acute chest syndrome (ACS) is one of the leading acute severe complications sickle-cell disease (SCD). Although Streptococcus pneumoniae (S pneumoniae) highly prevalent in children with SCD, its precise role ACS unclear. The efficacy 13-valent pneumococcal conjugate vaccine (PCV13) implementation on still unknown. To assess association PCV13 general pediatric population incidence SCD. This cohort study used an interrupted time-series analysis patient records from a national hospital-based...
ObjectiveTo examine whether the COVID-19 pandemic was associated with an increased incidence of uveitis in children.Study designWe performed a time-series analysis patient records from national, hospital-based, French surveillance system. All children hospitalized for France between January 2012 and March 2022 were included. The newly diagnosed per 100 000 trimester analyzed by quasi-Poisson regression. A cohort at Robert-Debré Hospital used to compare characteristics after before onset...
Using multiple national surveillance systems, we found an increase in the incidence of invasive pneumococcal disease during after relaxation non-pharmaceutical interventions against COVID-19, which strongly varied by age. Age groups with higher respiratory syncytial virus and influenza also experienced incidence, no change carriage.
Importance Mental disorders among the pediatric population are a major area of public health concern. Little is known regarding changes in hospital resource use related to mental (MH) long after onset COVID-19 pandemic March 2020. Objective To assess rates and trends hospitalizations emergency department (ED) visits MH self-harm (SH) children before during 3 years following onset. Design, Setting, Participants This cross-sectional study used national data. The sample included all MH-...
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The long-term impact of the COVID-19 pandemic on mental health children and adolescents is yet unknown. aim this study was to assess rates hospitalizations for (MH) conditions self-harm (SH) among (aged 6 17) in metropolitan France three years after onset. This a national cohort based hospital medico-administrative data (PMSI) collected pre-pandemic onset period (Jan. 2016 - Feb. 2020), initial (March 2020 May 1st post-pandemic year (June 2021), 2nd 2021 2022), 3rd 2022 2023). Monthly...
The long-term impact of the COVID-19 pandemic on mental health children and adolescents is yet unknown. We aimed to assess rate emergency department (ED) visits for (MH) conditions self-harm (SH) among (aged 6 17 years) in metropolitan France three years after onset. This a national cohort study based hospital medico-administrative data (PMSI – RPU database) collected pre-pandemic onset period (Jan. 2016 - Feb. 2020), initial (March 2020 May 1st post-pandemic year (June 2021), 2nd 2021...
Background: Acute chest syndrome (ACS) is a life-threatening complication of sickle-cell disease (SCD). Although respiratory pathogens are frequently detected in children with ACS, their respective role triggering ACS still unclear. We aimed to take advantage the unprecedented dynamics following non-pharmaceutical interventions (NPIs) analyze epidemiology.Methods: performed an interrupted time-series analysis patient records from national hospital-based surveillance system. All < 18 years...