A5101627704- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Nerve injury and regeneration
- Mosquito-borne diseases and control
- Heme Oxygenase-1 and Carbon Monoxide
- Calpain Protease Function and Regulation
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Signaling Pathways in Disease
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Complement system in diseases
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
University of Arizona
2017-2021
St. Joseph's Hospital and Medical Center
2018
University of California, Irvine
2017
Traumatic injury to CNS fiber tracts is accompanied by failure of severed axons regenerate and results in lifelong functional deficits. The inflammatory response trauma mediated a diverse set cells proteins with varied, overlapping, opposing effects on histological behavioral recovery. Importantly, the contribution individual complement spinal cord (SCI) pathology not well understood. Although presence components increases after SCI association myelin, it unknown whether affect axon growth...
The inflammatory response to spinal cord injury (SCI) involves localization and activation of innate adaptive immune cells proteins, including the complement cascade. Complement C3 is important for classical, alternative, lectin pathways activation, its cleavage products C3a C3b mediate several functions in context inflammation, but little known about potential on regeneration survival injured neurons after SCI. We report that 6 weeks dorsal hemisection with peripheral conditioning lesion,...
Alveolar macrophages are terminally differentiated, lung-resident of prenatal origin. unique in their long life and important role lung development function, as well lung-localized responses to infection inflammation. To date, no unified method for identification, isolation, handling alveolar from humans mice exists. Such a is needed studies on these innate immune cells various experimental settings. The described here, which can be easily adopted by any laboratory, simplified approach...
Toxoplasma gondii is an intracellular parasite that causes a long-term latent infection of neurons. Using custom MATLAB-based mapping program in combination with mouse model allows us to permanently mark neurons injected proteins, we found -injected (TINs) are heterogeneously distributed the brain, primarily localizing cortex followed by striatum. In addition, determined cortical TINs commonly (>50%) excitatory (FoxP2 + ) and striatal often (>65%) medium spiny (MSNs) ). By performing...
Abstract Toxoplasma gondii is an intracellular parasite that causes a long-term latent infection of neurons. Using custom MATLAB-based mapping program in combination with mouse model allows us to permanently mark neurons injected proteins, we found -injected (TINs) are heterogeneously distributed the brain, primarily localizing cortex followed by striatum. immunofluorescence co-localization assays, determined cortical TINs commonly (>50%) excitatory (FoxP2 + ) and striatal often (>65%)...