A5100413233- Marine Sponges and Natural Products
- Synthetic Organic Chemistry Methods
- RNA modifications and cancer
- Traditional and Medicinal Uses of Annonaceae
- Biological Activity of Diterpenoids and Biflavonoids
- Nuclear Structure and Function
- Bacteriophages and microbial interactions
- Natural product bioactivities and synthesis
- Particle Accelerators and Free-Electron Lasers
- HVDC Systems and Fault Protection
- Cancer Research and Treatments
- Photocathodes and Microchannel Plates
- Particle accelerators and beam dynamics
- Statistical Distribution Estimation and Applications
- RNA Research and Splicing
- Sesquiterpenes and Asteraceae Studies
- Marine Toxins and Detection Methods
- Synthesis of Organic Compounds
- Synthesis and Biological Activity
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Asymmetric Synthesis and Catalysis
- X-ray Spectroscopy and Fluorescence Analysis
- Probability and Risk Models
- Bioactive natural compounds
Stanford University
2015-2024
Dalian University of Technology
2023
Houston Methodist
2019-2023
Chinese Academy of Sciences
2007-2023
University of Chinese Academy of Sciences
2023
Northwest Institute of Eco-Environment and Resources
2023
Cornell University
2002-2022
Tunghai University
2022
Xinjiang Agricultural University
2021
ZheJiang Academy of Agricultural Sciences
2021
The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma (RCC). However, there have been no studies on the causative role of or any other initiation maintenance kidney tumorigenesis. Here, we show through a conditional transgenic mouse model that oncogene, but not RAS initiates maintains RCC. Desorption electrospray ionization-mass-spectrometric imaging was used to obtain chemical maps metabolites lipids RCC samples. Gene expression analysis revealed tumors...
Abstract Chemotherapy can eradicate a majority of cancer cells. However, small population tumor cells often survives drug treatments through genetic and/or non-genetic mechanisms, leading to recurrence. Here we report reversible chemoresistance phenotype regulated by the mTOR pathway. Through genome-wide CRISPR knockout library screen in pancreatic treated with chemotherapeutic agents, have identified pathway as prominent determinant chemosensitivity. Pharmacological suppression activity...
Abstract The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). considered undruggable to date. Here, we comprehensively identify genes essential for survival of high but not low cells by a CRISPR/Cas9 genome-wide screen MYC-conditional HCC model. Our uncovers novel synthetic lethal (MYC-SL) interactions and identifies most MYC-SL described previously. In particular, the reveals nucleocytoplasmic transport be interaction. We show that majority are...
The thermal emittance and temporal response of a photocathode set an upper limit on the maximum achievable electron beam brightness from photoemission source, or photoinjector. We present measurements these parameters over broad range laser wavelength for two different negative affinity (NEA) photocathodes. NEA GaAs GaAsP has been measured by techniques—a measurement size downstream solenoid, whose strength was varied, double slit transmission measurement—for spot sizes shapes. effect space...
We present a detailed study of the six-dimensional phase space electron beam produced by Cornell Energy Recovery Linac Photoinjector, high-brightness, high repetition rate (1.3 GHz) DC photoemission source designed to drive hard x-ray energy recovery linac (ERL). A complete simulation model injector has been constructed, verified measurement, and optimized. Both horizontal vertical 2D transverse spaces, as well time-resolved (sliced) space, were simulated directly measured at end for 19 77...
Cucumber green mottle mosaic virus (CGMMV) causes substantial global losses in cucurbit crops, especially watermelon. N6-methyladenosine (m6A) methylation RNA is one of the most important post-transcriptional modification mechanisms eukaryotes. It has been shown to have regulatory functions some model plants, but there no research regarding m6A modifications watermelon.We measured level resistant watermelon after CGMMV infection using a colorimetric method. And results found that...
To achieve the lowest emittance electron bunches from photoemission guns, it is essential to limit uncorrelated growth due space charge forces acting on bunch in vicinity of photocathode through appropriate temporal shaping optical pulses illuminating photocathode. We present measurements profile a bulk crystal GaAs illuminated with 520 nm wavelength frequency-doubled Yb-fiber laser. A transverse deflecting rf cavity was used make these measurements. The measured laser pulse and...
Abstract Background Due to language limitations, the abstract of journal article may be only way for people non-Chinese speaking countries know about trials in traditional Chinese medicine (TCM). However, little is known reporting quality these trial abstracts. Our study assess abstracts randomized controlled (RCT) published four leading medical journals TCM, and identify any differences between English version same publication. Method Two reviewers hand-searched Journal Integrated...
Thermal emittance measurements of a CsK2Sb photocathode at several laser wavelengths are presented. The is obtained with solenoid scan technique using high voltage dc photoemission gun. thermal 0.56+/-0.03 mm-mrad/mm(rms) 532 nm wavelength. results compared simple model and found to be in good agreement.
The Cornell University energy recovery linac (ERL) photoinjector has recently demonstrated operation at 20 mA for approximately 8 hours, utilizing a multialkali photocathode deposited on Si substrate. We describe the recipe deposition, and will detail parameters of run. Post-run analysis indicates presence significant damage to substrate, perhaps due ion back-bombardment from residual beam line gas. While exact cause substrate remains unknown, we multiple surface characterization techniques...
Our previous study indicated that DEK protein was overexpressed in colorectal carcinoma (CRC) compared with the normal mucosa. also significantly correlated prognostic characteristics of patients CRC, demonstrating played an important role CRC progression. In this work, we evaluate effects on biological behaviors and explore related molecular mechanisms. The results showed human tissues, Ki-67 index apoptotic index. depletion by RNAi SW-620 HCT116 cells decreased cell proliferation, but...
Abstract Double-hit lymphoma (DHL) is among the most aggressive and chemoresistant subtypes. DHLs carry genomic abnormalities in MYC, BCL2, and/or BCL6 oncogenes. Due to simultaneous overexpression of these driver oncogenes, are highly resistant frontline therapies. Most overexpress both MYC BCL2 oncogenes concurrently. We reasoned that suppression two would be more effective eradicating than inactivation single oncogene. XPO1 a receptor for nuclear cytoplasmic transport protein RNA species....
Abstract Background Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancers, is driven by oncogenic KRAS mutations. Farnesyl thiosalicylic acid (FTS), also known as salirasib, a RAS inhibitor that selectively dislodges active proteins from cell membrane, inhibiting downstream signaling. FTS has demonstrated limited therapeutic efficacy in PDAC patients despite being well tolerated. Methods To improve PDAC, we performed genome-wide CRISPR synthetic lethality screen to identify...
We present a comparison between space charge calculations and direct measurements of the transverse phase dominated electron bunches from high voltage dc photoemission gun followed by an emittance compensation solenoid magnet. The were performed using double-slit measurement system over range bunch current values. data are compared with detailed simulations 3D codes GPT Parmela3D. initial particle distributions generated measured temporal laser beam profiles at photocathode. brightness as...
Accurate assessment of changes in cellular differentiation status response to drug treatments or genetic perturbations is crucial for understanding tumorigenesis and developing novel therapeutics human cancer. We have developed a computational approach, the Lineage Maturation Index (LMI), define state hematopoietic malignancies based on their gene expression profiles. confirmed that LMI approach can detect known both normal malignant cells. To discover therapies, we applied this analyze...
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers. Dissecting tumor cell proteome from that of non-tumor cells in PDAC bulk critical for tumorigenesis studies, biomarker discovery, and development therapeutics. However, investigating has proven evasive due to tumor's extremely complex cellular composition. To circumvent this technical barrier, we have combined bioorthogonal noncanonical amino acid tagging (BONCAT) data-independent acquisition mass spectrometry (DIA-MS)...
In general, finite mixtures of distributions with increasing failure rates are not increasing. However, conditions have been given by Lynch [8] so that a mixture has rate. We establish similar results for other standard classes and also give examples which show although the assumptions stringent, continuous families lifetime do rates. result follows from Savits [12] techniques last-cited paper can be applied to as well.
Glioblastoma multiforme (GBM) is one of the most common glial cell tumors and has drawn more attention in clinic recent years. Brucine been reported to significantly suppress gastric cancer, lung prostate cancer growth vivo by inducing apoptosis. Here, effects brucine on U251 human glioma were investigated vitro proliferation assay, FACs, qPCR a xenograft tumor model. Treatment with reduced expression BCL-2 cyclooxygenase-2 (COX-2), while upregulated BAX cells resulted survival rate...
The failure rate of a mixture even the most standard distributions used in reliability can have complicated shape. However, rates mixtures two carefully selected will well-known bathtub Here we show that whole families distribtions bathtub-shaped rate.
The first enantioselective total syntheses of (+)-11,12-epoxy-11,12-dihydrocembrene-C 1 and (−)-7,8-epoxy-7,8-dihydrocembrene-C 2, two naturally occurring cembranoxides isolated from tropical marine soft corals, are achieved via a general approach by employing an intramolecular McMurry coupling Sharpless asymmetric epoxidation as key steps readily available starting materials. presented here verify the absolute stereochemistry assignment (11S,12S) Bowden et al. decades ago, epoxy...
The first total synthesis of two new natural prenylflavonoids, exiguaflavanone K (1) and (±)-leachianone G (2), has been achieved by condensation 2-hydroxy-3-prenyl-4,6-dimethoxymethoxyacetophenone (5) with hydroxy-protected benzaldehydes 6 7, respectively, followed cyclization demethoxymethylation.