A5102877295- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- Neuropeptides and Animal Physiology
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Asthma and respiratory diseases
- Pharmacological Receptor Mechanisms and Effects
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Allergic Rhinitis and Sensitization
- Microbial infections and disease research
- Forensic Toxicology and Drug Analysis
- Respiratory viral infections research
- Respiratory and Cough-Related Research
- Cancer, Stress, Anesthesia, and Immune Response
- COVID-19 epidemiological studies
- Infection Control and Ventilation
- Cannabis and Cannabinoid Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric health and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Receptor Mechanisms and Signaling
University of Montana
2018-2024
Carroll University
2023
McLean Hospital
2023
Behavioral Pharma (United States)
2023
Harvard University
2023
University of Colorado Boulder
2021
Albany College of Pharmacy and Health Sciences
2010
Albany Medical Center Hospital
2010
Australian Wine Research Institute
1990
Abstract Opioid use disorders (OUD) and overdose are public health threats worldwide. Widespread access to highly potent illicit synthetic opioids such as fentanyl is driving the recent rise in fatal overdoses. Vaccines containing fentanyl-based haptens conjugated immunogenic carrier proteins offer a long-lasting, safe, cost-effective strategy protect individuals from upon accidental or deliberate exposure its analogs. Prophylactic therapeutic active immunization with an anti-fentanyl...
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) , is one of the top infectious killers in world. The only licensed vaccine against TB, Bacille Calmette-Guérin (BCG), provides variable protection pulmonary especially adults. Hence, novel TB approaches are urgently needed. Both Th1 and Th17 responses necessary for yet effective adjuvants delivery systems inducing robust immunity lacking. Herein we describe a synthetic Mincle agonist, UM-1098, silica nanoparticle system...
Most licensed seasonal influenza vaccines are non-adjuvanted and rely primarily on vaccine-induced antibody titers for protection. As such, antigenic drift suboptimal vaccine strain selection often results in reduced efficacy. Further, H3N2 demonstrate poor efficacy compared to H1N1 type B vaccines. New vaccines, adjuvants, or delivery technologies that can induce broader cross-seasonal protection against drifted virus strains, likely through induction of protective T cell responses,...
Mycobacterium tuberculosis (Mtb) continues to be a major health threat worldwide, and the development of Mtb vaccines could play pivotal role in prevention control this devastating epidemic. Th17-mediated immunity has been implicated disease protection correlates immune against Mtb. Currently, there are no approved adjuvants capable driving Th17 response vaccine setting. Recent clinical trial results using trehalose dibehenate have demonstrated formulation-dependant proof concept adjuvant...
Abstract Opioid use disorders (OUD) and opioid-related fatal overdoses are a public health concern in the United States. Approximately 100,000 occurred annually from mid-2020 to present, majority of which involved fentanyl or analogs. Vaccines have been proposed as therapeutic prophylactic strategy offer selective long-lasting protection against accidental deliberate exposure closely related To support development clinically viable anti-opioid vaccine suitable for human use, incorporation...
Currently approved pharmacotherapies for opioid use disorders (OUDs) and overdose reversal agents are insufficient to slow the spread of OUDs due proliferation fentanyl. This is evident in 31% rise drug deaths from 2019 2022, with rates increasing 21.6 28.3 overdoses per 100,000 deaths. Vaccines a potential alternative or adjunct therapy treatment several substance (nicotine, cocaine) but have shown limited clinical success suboptimal antibody titers. In this study, we demonstrate that...
Despite the ever present need for an effective Mycobacterium tuberculosis vaccine efforts development have been largely unsuccessful. Correlates of immune protection against are not wholly defined, but Th1 and likely Th17 adaptive responses demonstrated to be necessary vaccine-mediated protection. Unfortunately, no approved adjuvants able drive a response, though recent clinical trials with CAF01 proof concept. Herein we discovery characterization new class potential Th17-inducing adjuvants,...
Adjuvants and immunomodulators that effectively drive a Th17-skewed immune response are not part of the standard vaccine toolkit. Vaccine adjuvants delivery technologies can induce Th17 or Th1/17 immunity protection against bacterial pathogens, such as tuberculosis (TB), urgently needed. Th17-polarized be induced using agonists bind activate C-type lectin receptors (CLRs) macrophage inducible (Mincle). A simple but effective strategy was developed for codelivering Mincle with recombinant...
Pseudomonas aeruginosa (Pa), a WHO priority 1 pathogen, resulted in approximately 559,000 deaths globally 2019. Pa has multitude of host-immune evasion strategies that enhance virulence. Most clinical isolates are infected by phage called Pf the ability to misdirect response and provide structural integrity biofilms. Previous studies demonstrate vaccination against coat protein (CoaB) Pf4 virions can assist clearance from dorsal wound model mice. Here, consensus peptide was derived CoaB...
Introduction Atopic diseases have been steadily increasing over the past decades and effective disease-modifying treatment options are urgently needed. These studies introduce a novel synthetic Toll-like receptor 4 (TLR4) agonist, INI-2004, with remarkable efficacy as therapeutic intranasal for seasonal allergic rhinitis. Methods Using murine airway sensitization model, impact of INI-2004 on responses was assessed. Results One or two doses significantly reduced resistance, eosinophil influx,...
The Macrophage-Inducible C-type Lectin receptor (Mincle) plays a critical role in innate immune recognition and pathology, therefore represents promising target for vaccine adjuvants. Innovative trehalose-based Mincle agonists with improved pharmacology potency may prove useful the development of Th17-mediated adaptive responses. Herein, we report on vitro silico investigations specific ligand–receptor interactions required effective engagement activation Th17-polarizing cytokines....
Rodent vendors are often utilized interchangeably, assuming that the phenotype of a given strain remains standardized between colonies. Several studies, however, have found significant behavioral and physiological differences Sprague Dawley (SD) rats from separate vendors. Prepulse inhibition startle (PPI), form sensorimotor gating in which low-intensity leading stimulus reduces response to subsequent stimulus, may also vary by vendor. Differences PPI rat strains well known, but divergence...
Abstract Influenza is a highly communicative viral pathogen that infects 9–35 million individuals and results in 12,000–56,000 deaths the US annually. For most commonly used seasonal influenza vaccine, historical efficacy rates range from 10–60% thus improvements to current vaccine are needed. We identified novel series of synthetic TLR7/8 ligands improve when alone or combination with our TLR4 ligand. In human PBMCs, elicited secretion inflammatory cytokines TNFα, IL-6, IL-1β as well...
Abstract The widespread illicit use of fentanyl and its analogs is associated with the increased incidence fatal drug overdoses in United States recent years. Pre-clinical studies vaccines targeting opioids show selectivity efficacy but clinical data suggests vaccine against drugs abuse may be limited by individual variability a requirement for high sustained antibody levels. New strategies are needed to enhance increase quantity quality anti-drug response. We investigated ability novel...
INTRODUCTION: The 5-year survival rate for all cancer types has risen to 68%, with many survivors (CS) reaching remission. While exercise is a proven therapy CS during and immediately following treatment, may assume that long-term (LTCS) no longer benefit from exercise-based interventions, leading its rare prescription or evaluation. However, up 95% of diagnoses are linked modifiable risk factors such as obesity, physical inactivity, the intake processed food/alcohol. Due these factors,...