A5020478567- Bacteriophages and microbial interactions
- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Plant Virus Research Studies
- Marine and coastal ecosystems
- Aquatic Ecosystems and Phytoplankton Dynamics
- Clostridium difficile and Clostridium perfringens research
- Peatlands and Wetlands Ecology
- Virology and Viral Diseases
- Plant Pathogens and Resistance
- Research Data Management Practices
- Plant and Fungal Interactions Research
- Bacterial Identification and Susceptibility Testing
- Pharmacological Effects of Natural Compounds
- Genetics, Bioinformatics, and Biomedical Research
- Aquatic Ecosystems and Biodiversity
- Rabies epidemiology and control
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Genomics and Phylogenetic Studies
- Animal Nutrition and Physiology
- Scientific Computing and Data Management
- Ginger and Zingiberaceae research
- Animal Virus Infections Studies
- Reproductive tract infections research
University of Michigan
2020
Michigan United
2020
University of Tennessee at Knoxville
2016-2019
Auburn University
2015
Annual cyanobacterial blooms dominated by Microcystis have occurred in western Lake Erie (U.S./Canada) during summer months since 1995. The production of toxins bloom-forming cyanobacteria can lead to drinking water crises, such as the one experienced city Toledo August 2014, when was rendered without for >2 days. It is important understand conditions and environmental cues that were driving this specific bloom provide a scientific framework management future events. To end, samples...
Harmful cyanobacterial blooms represent an increasing threat to freshwater resources globally. Despite increased research, the physiological basis of how dominant bloom-forming cyanobacteria, Microcystis spp., proliferate and then maintain high population densities through changing environmental conditions is poorly understood. In this study, we examined transcriptional profiles microbial community in Lake Taihu, China at 9 stations sampled monthly from June October 2014. To target...
The etiological agent of necrotic enteritis (NE) is Clostridium perfringens (CP), which an economically significant problem for broiler chicken producers worldwide. Traditional use in-feed antibiotic growth promoters to control NE disease have resulted in the emergence resistance CP strains. Identification probiotic bacteria strains as alternative antibiotics intestinal colonization crucial. Two experiments were conducted determine changes bacterial assemblages response infection and...
C57BL/6 mice are widely used for in vivo studies of immune function and metabolism mammals. In a previous study, it was observed that when purchased from different vendors were infected with Plasmodium yoelii, causative agent murine malaria, they exhibited both differential responses significantly parasite burdens: these patterns reproducible gut contents transplanted into gnotobiotic mice. To gain insight the mechanism resistance, we removed whole ceca two vendors, Taconic Biosciences (low...
Giant viruses are ecological agents that often involved in the top-down control of single-celled eukaryotic algae populations aquatic ecosystems. Despite an increased interest giant since discovery and characterization Mimivirus other viral giants, little is known about their physiology ecology. In this study, we characterized genome functional potential a virus infects freshwater haptophyte Chrysochromulina parva, originally isolated from Lake Ontario. This virus, CpV-BQ2, member...
Microcystis aeruginosa is a freshwater bloom-forming cyanobacterium capable of producing the potent hepatotoxin, microcystin. Despite increased interest in this organism, little known about viruses that infect it and drive nutrient mobilization transfer genetic material between organisms. The genomic complement sequenced phage suggests these are integrating into host genome, though activity has not been observed laboratory. While analyzing RNA-sequence data obtained from blooms Lake Tai...
Sphagnum -dominated peatlands play an important role in maintaining atmospheric carbon dioxide levels by modifying conditions the surrounding soil to favor growth of over that other plant species. This lowers rate decomposition and facilitates accumulation fixed form partially decomposed biomass. The unique environment produced enriches for a diverse microbial consortia benefit from support moss's growth, while also hostile conditions. While growing body research has begun characterize...
This study examined diel shifts in metabolic functions of Microcystis spp. during a 48-h Lagrangian survey toxin-producing cyanobacterial bloom western Lake Erie the aftermath 2014 Toledo Water Crisis. Transcripts mapped to genomes recently sequenced lower Great Lakes isolates showed distinct patterns gene expression between samples collected across day (10:00 h, 16:00 h) and night (22:00 04:00 h). Daytime transcripts were enriched related Photosystem II (e.g., psbA), nitrogen phosphate...
The gut microbiota has a key role in determining susceptibility to Clostridioides difficile infections (CDIs). However, much of the mechanistic work examining CDIs mouse models uses animals obtained from single source. We treated mice 6 sources (2 University Michigan colonies and 4 commercial vendors) with clindamycin, followed by C. challenge, then measured colonization levels throughout infection. were profiled via 16S rRNA gene sequencing examine variation across alterations due...
Exploratory Science Center, Merck & Co , Inc Cambridge, Massachusetts, United States of America Affiliation: Department Microbiology and Immunology, University Michigan, Ann Arbor, ORCID logo http://orcid org/0000-0003-3140-537X Patrick D Schloss * E-mail: pschloss@umich edu org/0000-0002-6935-4275 Introduction For most biologists, the ability to generate data has outpaced analyze those In addition building upon material from traditional coursework staying current on literature, Journal...
Efforts to catalog viral diversity in the gut microbiome have largely focused on DNA viruses, while RNA viruses remain understudied. To address this, we screened assemblies of previously published mouse metatranscriptomes for presence viruses. We identified coding-complete genomes an astrovirus and five mitovirus-like
Abstract Sphagnum-dominated peatlands play an important role in global carbon storage and represent significant sources of economic ecological value. While recent efforts to describe microbial diversity metabolic potential the Sphagnum microbiome have demonstrated importance its community, little is known about viral constituents. We used metatranscriptomics activity viruses infecting microbes within peat bog. The vegetative portions 6 plants were obtained from a peatland northern Minnesota...
Abstract The gut microbiota has a key role in determining susceptibility to Clostridioides difficile infections (CDIs). However, much of the mechanistic work examining CDIs mouse models use animals obtained from single source. We treated mice 6 sources (2 University Michigan colonies and 4 commercial vendors) with clindamycin, followed by C. challenge then measured colonization levels throughout infection. were profiled via 16S rRNA gene sequencing examine variation across alterations due...