A5003422586- Transgenic Plants and Applications
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 and COVID-19 Research
- Plant tissue culture and regeneration
- Garlic and Onion Studies
- CRISPR and Genetic Engineering
- Algal biology and biofuel production
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Genetics and Reproduction
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Plant Genetic and Mutation Studies
- Herbal Medicine Research Studies
- Viral gastroenteritis research and epidemiology
- Medicinal Plants and Neuroprotection
- Essential Oils and Antimicrobial Activity
- Biochemical and Structural Characterization
- COVID-19 Clinical Research Studies
- Coconut Research and Applications
- Cervical Cancer and HPV Research
- Seed and Plant Biochemistry
- Phytoestrogen effects and research
- Seaweed-derived Bioactive Compounds
- Microbial Metabolic Engineering and Bioproduction
- Medical and Biological Ozone Research
Bharathiar University
2013-2023
Chulalongkorn University
2020-2022
Bangalore University
2016
Abstract Formation of oxidative stress in dermal fibroblasts plays crucial roles aging processes skin. The use phytochemicals that can promote capacity to combat is an attractive strategy prevent skin and beauty. Centella asiatica has been used treat multitude diseases for centuries. Previous investigations demonstrated extracts from C. have a broad range beneficial activities through their antioxidant activity. Hence, the extract this medicinal plant could be great candidate anti-skin-aging...
The increase in the world population, advent of new infections and health issues, scarcity natural biological products have spotlighted importance recombinant protein technology its large-scale production a cost-effective manner. Microalgae become significant promising platform with potential to meet increasing demand for proteins other biologicals. are safe organisms that can grow rapidly easily cultivated basic nutrient requirements. Although continuous efforts led considerable progress...
Immune checkpoint antibodies in cancer treatment are receptor-ligand pairs that modulate immunity. PD-1/PD-L1 pathway has emerged as one of the major targets immunotherapy. Atezolizumab, first anti-PD-L1 antibody approved for metastatic urothelial, non-small cell lung, small lung and triple-negative breast cancers, is produced Chinese Hamster Ovary (CHO) cells with several limitations i.e., high-production costs, low-capacity yields, contamination risks. Due to rapid scalability low...
The therapeutic blockade of inhibitory PD-1 signaling has emerged as an effective approach for cancer immunotherapy. Nivolumab (Opdivo®), a monoclonal antibody (mAb) targeting the immune checkpoint, is approved treatment several indications. It functions by blocking PD-1-mediated T-cell inhibition thus reinstating anticancer responses. Tremendous advances in plant biotechnology offer alternative and economical strategy to produce mAbs immune-based therapies. In this study, recombinant...
Isoflavonoids, the diverse group of secondary metabolites derived from phenylpropanoid pathway, are distributed predominantly in leguminous plants and play a vital role promoting human health. Genetic engineering metabolite synthesis pathway has turned out to be an attractive approach for production various metabolites. In our study, we attempted produce isoflavone genistein, well-known health-promoting metabolite, Allium cepa L. (onion) by introducing Glycine max Isoflavone synthase...
Despite the current advances in global vaccination against SARS-CoV-2, boosting is still required to sustain immunity population, and induction of sterilizing remains as a pending goal. Low-cost oral immunogens could be used basis for design affordable easy-to-administer booster vaccines. Algae stand promising platforms produce at low cost, it possible use them delivery carriers since they are edible (not requiring complex purification formulation processes). Herein, Chlamydomonas-made...
Cobra (Naja kaouthia) venom contains many toxins including α-neurotoxin (αNTX) and phospholipase A2 (PLA2), which can cause neurodegeneration, respiratory failure, even death. The traditional antivenom derived from animal serum faces challenges limitations. Heavy-chain-only antibodies (HCAb), fusing VHH with human IgG Fc region, offer advantages in tissue penetration, antigen binding, extended half-life. This research involved the construction transient expression of two types VHH-FC are...
The aim of the study was to evaluate phytochemical components and antioxidant potential methanolic hydrophilic extracts isolated from in vivo vitro cultures onion varieties Bellary CO 3. Phytochemical like total flavonoids, phenolics, ascorbic acid anthocyanins were analyzed. activities examined by DPPH FRAP methods. results indicated that both exhibited radical scavenging activity. activity 3 ranged 6.5% - 11.8% whereas values 0.9 3.3 μM/100 μg FW. 9.9 29.9 mg/kg, vitamin-C 48.6 78.6...
Two highly human pathogenic coronaviruses outbreak in the beginning of 21st century i.e. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East (MERS-CoV) 2002 2012 respectively caused high pathogenicity fatality rates populations. Recently, a new coronavirus named as SARS-CoV-2 or nCoV-2019 was first reported Wuhan, China December 2019 which is responsible for an acute respiratory illness referred Disease (COVID-19), ongoing pandemic. third known virus affecting...
Isoflavonoids, the diverse group of secondary metabolites derived from phenylpropanoid pathway, are distributed predominantly in leguminous plants. It has received considerable attention recent days due to its health promoting benefits and is known prevent certain diseases humans. These isoflavonoids synthesized flavonoid intermediates pathway by enzyme isoflavone synthase. Metabolic engineering isoflavonoid biosynthesis non-legume crop plants could offer these compounds plant species...
Green leafy vegetables (GLVs) symbolize a class of low cost, neglected plants that are known to be wealthy spring natural antioxidants. In the present study, phytochemical and radical scavenging activities both stem leaf fractions 20 commonly consumed GLVs tropical India were evaluated using different systems assays like total antioxidant assay, ferric reducing potential (FRAP), 2,2-diphenylpicrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), hydrogen...
Omalizumab, the anti-immunoglobulin IgE antibody is only approved and available monoclonal as an auxiliary medicament for severe respiratory allergic reactions. It forms small size immune complexes by binding to free IgE, thereby inhibiting interaction of with its receptors. Additionally, anti-IgE can also differently shape airflow impeding stimulation receptors present on structural cells in tract. The study aimed use plants expression system anti-human production, using Nicotiana...