A5075723846- Genetic factors in colorectal cancer
- Latin American Urban Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Respiratory viral infections research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- Microscopic Colitis
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal Cancer Screening and Detection
- Blood transfusion and management
- Viral gastroenteritis research and epidemiology
- Hemostasis and retained surgical items
- Cardiac, Anesthesia and Surgical Outcomes
- Architecture and Art History Studies
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- Cultural Heritage Management and Preservation
Fundación Instituto Valenciano de Oncología
2024-2025
St Mark's Hospital
2019-2024
Complexo Hospitalario Universitario A Coruña
2023
Queen Mary University of London
2021-2022
London North West Healthcare NHS Trust
2020-2022
Imperial College London
2018-2021
St. Mark's Hospital
2020-2021
University College Hospital
2021
University College London
2021
Universidad Politécnica de Madrid
2012-2019
Abstract Molecular clocks that record cell ancestry mutate too slowly to measure the short-timescale dynamics of renewal in adult tissues. Here, we show fluctuating DNA methylation marks can be used as cells where ongoing and demethylation cause repeated ‘flip–flops’ between methylated unmethylated states. We identify endogenous CpG (fCpG) sites using standard arrays develop a mathematical model quantitatively human stem from these data. Small intestinal crypts were inferred contain slightly...
A. Garcia‐Reyne, F. López‐Medrano, J.M. Morales, C. García Esteban, I. Martín, Eraña, Y. Meije, Lalueza, Alastruey‐Izquierdo, J.L. Rodríguez‐Tudela, Aguado. Cutaneous infection by Phomopsis longicolla in a renal transplant recipient from Guinea: first report of human this fungus. Transpl Infect Dis 2011: 13: 204–207. All rights reserved Abstract: We the case 72‐year‐old female with nodular lesion distal phalange third left finger produced dematiaceous fungus that was identified as . She...
Patients with familial adenomatous polyposis (FAP) are at increased risk of developing gastric adenomas. There is limited understanding their clinical course and no consensus on management. We reviewed the management adenomas in patients FAP from two centers.Patients histologically confirmed were identified between 1997 2018. Patient demographics, adenoma characteristics, management/surveillance outcomes collected.Of 726 FAP, 104 (14 %; 49 female) diagnosed a median age 47 years (range 19 -...
Total colectomy with ileorectal anastomosis (TC-IRA) is a surgical option for patients familial adenomatous polyposis (FAP). Regular endoscopic surveillance of the rectum recommended to prevent rectal cancer. We aimed document polyp progression in following TC-IRA and evaluate role polypectomy during surveillance.Patients FAP who underwent between 1990 2017 were identified. Demographic, genetic data retrieved. Cumulative adenoma (polyp) counts obtained, whilst accounting any polypectomies...
Attenuated familial adenomatous polyposis is characterised by low number (≤100) and delayed development of colorectal adenomas. Various definitions have been used, genotype-phenotype correlations suggested.We aimed to evaluate phenotypic genotypic correlation in patients with presumed attenuated assess variability.This a retrospective study.This study was conducted at tertiary registry.Individuals were identified. Phenotypic group defined as 100 or fewer adenomas age 25 years variant the...
Familial adenomatous polyposis (FAP) is a condition caused by constitutional pathogenic variant of the coli gene that results in intestinal adenoma formation and colorectal cancer, necessitating pre-emptive colectomy. We sought to examine interaction between mucosal immune system commensal bacteria FAP test for dysfunction might accelerate tumorigenesis. Colonic biopsies were obtained from macroscopically normal tissue 14 healthy donors 13 patients with during endoscopy or surgical...
Abstract Background Respiratory syncytial virus (RSV) is a highly infectious disease that poses significant clinical and medical burden, as well social disruption economic costs, recognized by the World Health Organization public health issue. After several failed attempts to find preventive candidates (compounds, products, including vaccines), new alternatives might be available, one being nirsevimab, first only option approved for RSV prevention in neonates infants during their season. The...
<h3>Introduction/Background</h3> Tumour size is one of the key prognostic markers currently used to tailor type and radicality surgical treatment. Presented study aimed evaluate accuracy preoperative tumour assessment by imaging using data from SENTIX: a prospective, single-arm, international multicenter sentinel lymph node biopsy without pelvic dissection in patients with early-stage cervical cancer. <h3>Methodology</h3> Between 05/2016–09/2020, forty-seven sites across 18 countries...
AbstractFrom September 1984 to July 1987, 33 children received intra-operative radiotherapy as part of a multidisciplinary tumor treatment. Their age ranged from 2 17 years. Tumors types: Ewing's sarcoma (n=11), osteosarcoma (n=8), soft tissue sarcomas (n=5), Wilms' (n=3), neuroblastoma malignant pheochromocytoma (n=l), Hodgkin's disease (n=1), and optic nerve glioma (n=1). In 25 patients the was localized while 8 had distant metastases. Intraoperative used in 26 previously untreated radical...
ABSTRACT Objectives: Prophylactic colectomy at a premalignant stage is the cornerstone of management familial adenomatous polyposis (FAP). Before surgery, colonoscopy surveillance recommended in children with FAP. This study aimed to examine natural history FAP by evaluating adenoma progression and factors influencing timing colectomy. Method: Patients younger than 18 years first who had undergone more 1 were identified. Demographic, endoscopic, genetic, surgical data retrieved. Cumulative...
Abstract Background and study aims Some patients with familial adenomatous polyposis (FAP) extensive duodenal or cancer require total duodenectomy. Regular postoperative endoscopic surveillance of the remaining jejunum stomach is recommended, but little known about outcomes after this surgery. Patients methods FAP who underwent either pancreatoduodenectomy (PD) pancreas-preserving duodenectomy (PPTD) were identified at two expert centers. Data collected, as well survival outcomes. Results...
Los años cincuenta constituyen un punto de inflexión determinante en la carrera Louis I. Kahn; momento el que su ambición por comprender origen mismo arquitectura le llevó a plantear una serie trasformaciones decisivas concepción del orden y espacio moderno. Sus intuiciones sobre condición autónoma e indivisible estancia desde íntimo compromiso entre envolvente estructura se entrelazaron con interés simultáneo hacia los procesos crecimiento forma, parte influenciado figuras clave contexto...
Objetivo: El objetivo de este estudio fue determinar la contribución valor filgotinib en el tratamiento colitis ulcerosa moderada a grave España, comparado con sus principales alternativas terapéuticas. Metodología: Se seleccionó marco EVIDEM para análisis decisión multicriterio (MCDA). está formado por 12 criterios cuantitativos y 4 contextuales. llevó cabo una revisión literatura poblar evidencia relevante cada criterio. Un panel multidisciplinar 8 expertos determinó vedolizumab,...