A5090829113- Pharmacological Effects and Toxicity Studies
- Childhood Cancer Survivors' Quality of Life
- Clinical Nutrition and Gastroenterology
- Ethics in Clinical Research
- Ethics and Legal Issues in Pediatric Healthcare
- Adolescent and Pediatric Healthcare
- Inflammatory Bowel Disease
- Nutrition and Health in Aging
- Pediatric Pain Management Techniques
- Dialysis and Renal Disease Management
- Hemoglobinopathies and Related Disorders
- Patient Dignity and Privacy
- Genomics and Chromatin Dynamics
- Zoonotic diseases and public health
- Hemophilia Treatment and Research
- COVID-19 Pandemic Impacts
- Osteoarthritis Treatment and Mechanisms
- Complementary and Alternative Medicine Studies
- Therapeutic Uses of Natural Elements
- Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Stoma care and complications
- Palliative Care and End-of-Life Issues
- Child Nutrition and Feeding Issues
- Histone Deacetylase Inhibitors Research
Children's Healthcare of Atlanta
2019-2023
Royal Devon & Exeter NHS Foundation Trust
2017-2023
Fairmont State University
2022
West Virginia Department of Education
2022
Aflac (United States)
2019-2021
Emory University
2019-2021
Wellcome Trust
2016-2020
Johns Hopkins University
2017
Johns Hopkins Medicine
2017
Sidney Kimmel Cancer Center
2017
Summary Background Few studies have reported the systematic use of exclusive enteral nutrition in perioperative setting. Aim To test hypothesis that provides a safe and effective bridge to surgery reduces post‐operative complications, adult patients with Crohn's disease requiring urgent for stricturing or penetrating complications. Methods Patients treated prior were each matched two control behaviour, type surgery, age at diagnosis duration. Data on phenotype, nutritional status, operative...
SET and MYND domain (Smyd) proteins are involved in the transcriptional regulation of cellular proliferation development vertebrates. However, vivo functions mechanisms by which these act poorly understood.We have used biochemical genetic approaches to study role a Smyd protein Drosophila. We identified eleven Drosophila genes that encode proteins. CG14122 encodes Smyd4 homologue we named dSmyd4. dSmyd4 repressed transcription recruited class I histone deacetylases (HDACs). A region...
Health research is essential for better public health and care. However, the use of personal data in could be put under threat by amendments recently adopted European Parliament. Individual patient records provide a vital resource benefit society. These form basis observational studies factors influencing disease help researchers identify suitable participants to invite them take part clinical trials concerning their condition. It equally make most that has already been completed. By...
Home parenteral support (HPS) is an essential but potentially burdensome treatment that can affect quality of life (QoL). The aims this longitudinal study were to understand whether any changes in HPS over time associated with QoL. Parenteral Nutrition Impact Questionnaire (PNIQ) was used, and data collected on prescribed at three points. Data analysed using multi-level mixed regression models presented as effect size adjusted for confounders. Study recruited 572 participants from 15 sites....
Mothers of children with haemophilia (CWH) experience guilt related to this genetic condition. Several factors contributing maternal have been identified, but the scope and extent not previously quantified.This study provides insight into mothers CWH how they perceive manage guilt. It then identifies most common helpful coping mechanisms.Between May October 2021, we distributed an anonymous electronic survey CWH. The Parent Experience Child Illness measured guilt, PROMIS Proxy for Life...
Acupuncture and acupressure points correlate well with sites on the body that have low transcutaneous electrical resistance (TER). Using lightly sedated, adult Sprague-Dawley rats, we identified an acupoint (i.e. site TER) located hind limb of rat compared effects at this nociceptive threshold to adjacent, non-acupoint high TER). Focal pressure (55.42±2.2 g) was applied for 10 minutes tail flick response (TFR) determined by draping distal portion over a heated wire (75±5°C). Three trials...
Many pleiotropic roles have been ascribed to small abundant HMG-Box (HMGB) proteins in higher eukaryotes but their precise function has remained enigmatic. To investigate genetically we generated a defined deficiency uncovering the functionally redundant genes encoding HMGD and HMGZ, Drosophila counterparts of HMGB1-3 mammals. The resulting mutant is strong hypomorphic allele HmgD/Z. Surprisingly this viable exhibits only minor morphological defects even when homozygous. However, interacts...
Abstract Background Integration of nonpharmacological therapies, such as cognitive and behavioral pain management strategies, is recommended to support comprehensive disease among children adolescents with sickle cell (SCD). The Comfort Ability Program for Sickle Cell Pain (CAP SCP) introduces psychological biobehavioral strategies SCD. This study aimed pilot the implementation CAP SCP in a group setting hospitalized SCD examining feasibility, acceptability, preliminary effectiveness on...
Background: Considering the possible trajectories of COVID-19 pandemic is important to inform both short- and long-term responses prepare for pandemics future. We describe a framework explore four futures over next five years, examining how each could play out globally.Methods: have defined based on biology severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) its human host, scientific it. Rather than predictions, these represent plausible possibilities are used as help what happen....
Standardized pain assessment and interventions are recommended for youth hospitalized pain. This quality improvement (QI) project integrated into a pediatric psychology service aimed to increase the standardized of pain-related functional ability with sickle cell disease (SCD) pain.Children adolescents (n=102) SCD referred consultation poor coping in response during hospitalization completed validated self-report addition intensity inpatient visits. At time initiative, routine was not...
This article describes a quality improvement (QI) initiative integrated into pediatric psychology service that focused on improving the standardized assessment of pica behaviors in patients with sickle cell disease (SCD). Pica, persistent mouthing or eating nonnutritive substances, can result serious health complications and is known problem for SCD. At time project initiation, were assessed, average, 36% new consultations completed by providers SCD across our hospital system. The primary...
Treating geriatric patients can be difficult. Patients often present with subtle or atypical symptoms, and end-of-life care is rarely neatly packaged. We a case of 97 years old Hispanic male multiple medical problems who was diagnosed mantle cell lymphoma after thoracentesis from what thought to para-pneumonic effusion. An oncology evaluation determined that he not candidate for aggressive treatment. There no evidence curative treatment lymphoma. To complicate the decision making process...
Background: Despite data reporting that exclusive enteral nutrition (EEN) improves nutritional status and inflammation in patients with Crohn's disease, few studies have reported its systematic use the perioperative setting. EEN involves of a liquid formula to meet all an individual's dietary requirements. We sought test hypothesis provides safe effective bridge surgery reduces post-operative complications adult disease requiring urgent for stricturing or penetrating complications. Methods:...
72 Background: Many young women with early BC require systemic therapy (ST) which can result in ovarian damage leading to infertility. Fertility preservation (FP) be performed prior ST, however uptake is low. Data suggest oncology providers do not routinely discuss the risk of treatment related infertility (TRI) or FP BC. Methods: We created a QI protocol ensure address fertility needs Non-pregnant age 18-44 years stage I-III who have initiated ST are identified by screening clinic...
I must say that liked this book. In a most logical and readable fashion it set about what can be rather dour, but yet clinically important topic. Opening chapters on the normal tendon etiology of tendinitis were followed by more …
First2 Network, NASA Educator Resource Center (ERC), WV Department of Education (WVDE), and Alliance for STEM the Arts offer compilations resources that serve undergraduate K12 students, parents, educators, industry, other stakeholders throughout WV. Learn how to use submit events these resource compilations, they are connected. Network’s Hub is a searchable online inventory West Virginia STEM-related assets, opportunities. The ERC aims spotlight internships high school students through...