A5044920884- Sarcoma Diagnosis and Treatment
- Congenital limb and hand anomalies
- Soft tissue tumor case studies
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Evolution and Paleontology Studies
- Hip disorders and treatments
- Nuclear Structure and Function
- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- Forensic Anthropology and Bioarchaeology Studies
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Bone fractures and treatments
- Craniofacial Disorders and Treatments
- Health, Environment, Cognitive Aging
- Physiological and biochemical adaptations
- Medical Imaging Techniques and Applications
- Medical and Biological Sciences
- Bone and Joint Diseases
- Stochastic processes and statistical mechanics
- Tendon Structure and Treatment
- Cell Image Analysis Techniques
University College London
2020-2023
Royal Veterinary College
2017-2023
University of London
2021
Inria Saclay - Île de France
2015
ETH Zurich
2011-2012
<ns4:p>Research software is often developed with expedience as a core development objective because experimental results, but not the software, are specified and resourced project output. While such code can help find answers to specific research questions, it may lack longevity flexibility make reusable. We reimplemented BoneJ, our for skeletal biology image analysis, address design limitations that put at risk of becoming unusable. improved quality BoneJ by following contemporary best...
<ns4:p>Research software is often developed with expedience as a core development objective because experimental results, but not the software, are specified and resourced project output. While such code can help find answers to specific research questions, it may lack longevity flexibility make reusable. We reimplemented BoneJ, our for skeletal biology image analysis, address design limitations that put at risk of becoming unusable. improved quality BoneJ by following contemporary best...
Intra-cortical bone remodelling is a cell-driven process that replaces existing tissue with new in the cortex, leaving behind histological features called secondary osteons. While scaling of dimensions on macroscopic scale well known, less known about how spatial osteons vary relation to adult body size species. We measured cross-sectional area individual intact and their central Haversian canals transverse sections from 40 stylopodal bones 39 mammalian species (body mass 0.3–21 000 kg)....
Birds undisputedly range amongst nature's foremost navigators. To successfully navigate between breeding and wintering quarters, they, in addition to other natural orientation cues, rely on their ability sense the Earth's magnetic field. For this reason, migratory birds have become key model species for studying sensory mechanisms underlying field-guided navigation, as evidenced by identification of several brain regions believed be involved processing field information. However, there is...
The BFW model introduced by Bohman, Frieze, and Wormald [Random Struct. Algorithms, 25, 432 (2004)] recently investigated in the framework of discontinuous percolation Chen D'Souza [Phys. Rev. Lett., 106, 115701 (2011)], is studied on square simple-cubic lattices. In two three dimensions, we find numerical evidence for a strongly transition. clusters at threshold are compact with fractal surface dimension $d_f=1.49\pm0.02$. On lattice, distinct jumps size largest cluster observed. We proceed...
The interfascicular matrix (IFM; also known as the endotenon) is critical to mechanical adaptations and response load in energy-storing tendons, such human Achilles equine superficial digital flexor tendon (SDFT). We hypothesized that IFM a progenitor cell niche housing an exclusive subpopulation.
Bone adaptation is modulated by the timing, direction, rate and magnitude of mechanical loads. To investigate whether frequent slow, or infrequent fast, gaits could dominate bone to load, we compared scaling limb bones from two mammalian herbivore clades that use radically different high-speed gaits, bipedal hopping (suborder Macropodiformes; kangaroos kin) quadrupedal galloping (order Artiodactyla; goats, deer kin). Forelimb hindlimb were collected 20 artiodactyl 15 macropod species (body...
Many physiological, biomechanical, evolutionary and clinical studies that explore skeletal structure function require successful separation of trabecular from cortical compartments a bone has been imaged by X-ray micro-computed tomography (micro-CT) prior to analysis. Separation often involves manual subdivision these two similarly radio-opaque compartments, which can be time-consuming subjective. We have developed an objective, semi-automated protocol reduces user bias enables...
Changes in trabecular micro-architecture are key to our understanding of osteoporosis. Previous work focusing on structure model index (SMI) measurements have concluded that disease progression entails a shift from plates rods bone, but SMI is heavily biased by bone volume fraction. As an alternative SMI, we proposed the ellipsoid factor (EF) as continuous measure local shape between plate-like and rod-like extremes. We investigated relationship EF distributions, fraction geometry murine...
Abstract Worldwide research groups and funding bodies have highlighted the need for imaging biomarkers to predict osteoarthritis (OA) progression treatment effectiveness. Changes in trabecular architecture, which can be detected with non‐destructive high‐resolution CT imaging, may reveal OA before apparent articular surface damage. Here, we analysed tibial epiphyses of STR/Ort (OA‐prone) CBA (healthy, parental control) mice at different ages characterise effects mouse age strain on multiple...
Changes in trabecular micro-architecture are key to our understanding of osteoporosis. Previous work focusing on structure model index (SMI) measurements have concluded that disease progression entails a shift from plates rods bone, but SMI is heavily biased by bone volume fraction. As an alternative SMI, we proposed the Ellipsoid Factor (EF) as continuous measure local shape between plate-like and rod-like extremes. We investigated relationship EF distributions, fraction geometry murine...
Intra-cortical bone remodelling is a cell-driven process that replaces existing tissue with new in the cortex, leaving behind histological features called secondary osteons. While scaling of dimensions on macroscopic scale well known, less known about how spatial osteons vary relation to adult body size species. We measured cross-sectional area individual intact and their central Haversian canals transverse sections from 40 stylopodal bones 39 mammalian Scaling analysis our data shows mean...
Abstract Bone adaptation is modulated by the timing, direction, rate, and magnitude of mechanical loads. To investigate whether frequent slow, or infrequent fast, gaits could dominate bone to load, we compared scaling limb bones from two mammalian herbivore clades that use radically different high-speed gaits, bipedal hopping (suborder Macropodiformes; kangaroos kin) quadrupedal galloping (order Artiodactyla; goats, deer kin). Forelimb hindlimb were collected 20 artiodactyl 15 macropod...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Abstract The interfascicular matrix (IFM) is critical to the mechanical adaptations and response load in energy-storing tendons, such as human Achilles equine superficial digital flexor tendon (SDFT). We hypothesized that IFM a progenitor cell niche housing an exclusive subpopulation. Immunolabelling of SDFT was used identify niche, localising expression patterns CD31 (endothelial cells), CD146 (IFM cells) LAMA4 basement membrane marker). Magnetic-activated sorting employed isolate compare...
R scripts and MySQL queries, along with raw measurements, spreadsheets database tables that form the basis of figures 3-7 1-3 Doube et al. 2018