The role of mechanical strain and estrogen status in regulating ERalpha levels bone cells was studied female rats. OVX is associated with decreased protein expression/osteocyte, whereas habitual artificial loading has only a small but positive effect, except on the ulna's medial surface, where stimulates reversal resorption to formation.Osteoporosis most widespread failure bones' ability match their architectural strength load bearing. In men women, severity loss bioavailability estrogen....

ObjectivesChanges in subchondral bone (SCB) and cross-talk with articular cartilage (AC) have been linked to osteoarthritis (OA). Using micro-computed tomography (micro-CT) this study: (1) examines changes SCB architecture a non-invasive loading mouse model which focal AC lesions are induced selectively the lateral femur, (2) determines any modifications contralateral knee, gait, might complicate use of limb as an internal control.MethodsRight knee joints CBA mice were loaded: once 2weeks...

Abstract The contribution of the SNS to bone's response mechanical loading is unclear. Using a noninvasive model axial murine tibia, we found that sciatic neurectomy enhances load-induced new cortical bone formation and pharmacological blockade does not affect such responses, indicating mediate osteogenic effects in bone. Introduction: There increasing evidence sympathetic nervous system (SNS) contributes regulation mass may influence remodeling by modulating bones' load-bearing. aim this...

This study used a PCR-RFLP test to determine the presence of Leishmania (Leishmania) chagasi in 16 captive wild felids [seven Puma concolor (Linnaeus, 1771); five Panthera onca 1758) and four Leopardus pardalis 1758)] at zoological park Federal University Mato Grosso, Brazil. Amplification spp. DNA was seen samples from pumas one jaguar, species characterized as L. using restriction enzymes. It is already known that domestic can act reservoir endemic areas, further studies are necessary...

Objective Osteoarthritis (OA) is a common chronic disease for which disease‐modifying therapies are not currently available. Studies to seek new targets slowing the progress of OA rely on mouse models, but these do allow longitudinal monitoring development. This study was undertaken determine whether gait can be used measure severity in STR/Ort model spontaneous and changes related joint pain. Methods Gait monitored using treadmill‐based video system. Correlations between at 3 treadmill...

Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in strength. It is unclear whether this due to of osteocytes sense strain, osteoblasts form or insufficient mechanical stimulus. can be restored aged by surgical neurectomy, suggesting that changes loading history rescue mechanoadaptation. We use non-biased, whole-bone tibial analyses, along with characterisation surface strains ensuing mechanoadaptive responses mice at a range ages, explore...

Cedrela odorata L. (Meliaceae) is a native plant of the Amazon region and its inner stem bark used in treatment diabetes form maceration Brazilian popular medicine. Until now, there no scientific study on this activity. The present was aimed at evaluating anti-hyperglycemic activity, anti-diabetic, toxicity, antioxidant potential mechanism action hydroethanolic extract odorata.The prepared by 70% ethanol for 7 days to obtain (HeECo). preliminary phytochemical analysis performed according...

Osteoarthritis (OA), affecting joints and bone, causes physical gait disability with huge socio-economic burden; treatment remains palliative. Roles for antioxidants in protecting against such chronic disorders have been examined previously. Sulforaphane is a naturally occurring antioxidant. Herein, we explore whether SFX-01®, stable synthetic form of sulforaphane, modifies gait, bone architecture slows/reverses articular cartilage destruction spontaneous OA model STR/Ort mice. Sixteen mice...

Relatam-se os achados epidemiológicos, clínicos, patológicos e micológicos de conidiobolomicose em ovinos no Estado Mato Grosso. A doença ocorreu uma propriedade município Nobres, um rebanho com 40 ovelhas adultas, entre meses janeiro a junho 2007. Aproximadamente 30% dos da adoeceram todos doentes morreram curso clínico 2-5 semanas. O quadro foi caracterizado por apatia, emagrecimento, dificuldade respiratória dispnéia, respiração ruidosa oral, secreção nasal mucosa ou sero-sanguinolenta,...

ObjectivesHuman osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify predisposing factors. We exploit the lack of overt in female and both sexes parental, control CBA explore whether early divergence tibial bone mass or shape are linked emergent OA.MethodWe undertook detailed micro-CT comparisons trabecular cortical bone, multiple structural/architectural parameters finite element...

We reported here the first known case of natural infection a lion (Panthera leo-Linnaeus, 1758) with Leishmania (Leishmania) chagasi (L. chagasi) in Brazil. The specimen was created by circus handler state Mato Grosso and donated to zoological park Federal University Grosso. Infection L. detected using PCR-RFLP test. It that domestic felids can act as reservoir endemic areas, making it important studies demonstrate their participation epidemiological chain. this work wild animals have an...

This report describes toxoplasmosis infection in a black-headed night monkey (Aotus nigriceps) from the Zoological Park of Federal University Mato Grosso, Brazil. The animal was submitted alive to Veterinary Hospital Grosso presenting neurologic clinical signs. There were no improvements on animal's condition after treatment, so it euthanized. At necropsy, most significant gross lesions observed hemorrhages diffusely scattered throughout cerebral hemispheres. Histologic findings...

Disuse osteoporosis occurs after extended periods of bed rest or nerve damage leading to increased risk fracture. It remains be established, however, whether the trajectory bone loss is equivalent in bone's cortical and trabecular compartments following long-term reduced loading. Herein, we evaluate sciatic neurectomy-related tibia by microCT. The right hind limb seventeen 12 week-old female mice was subjected neurectomy (right, SN; left, contralateral internal control) animals were...

Epidural anesthesia in dogs is a locoregional technique used veterinary medicine, becoming an important integrated application the anesthetic protocol to provide safer and more effective analgesia patients. For this, professionals must adhere rigorous guidelines possess technical skills. In this context, education, development of practical clinical skills represents crucial aspect training these professionals. However, traditional teaching methods have proven insufficient ensure consistent...

ABSTRACT: Rapid prototyping (RP) is an innovative technology that allows one to obtain a prototype of mold quickly and accurately from virtual model. This study aimed establish the use photogrammetry 3D for production bone biomodels canine species training in orthopedic techniques veterinary medicine. Virtual bio-modelling was performed by technique with commercial anatomical pieces, physical biomodelling printing. Osteotomies were on served as platforms osteosynthesis femur ileum, final...

Changes in trabecular micro-architecture are key to our understanding of osteoporosis. Previous work focusing on structure model index (SMI) measurements have concluded that disease progression entails a shift from plates rods bone, but SMI is heavily biased by bone volume fraction. As an alternative SMI, we proposed the ellipsoid factor (EF) as continuous measure local shape between plate-like and rod-like extremes. We investigated relationship EF distributions, fraction geometry murine...

ABSTRACT: The aim of this report is to describe the clinical, pathological and imaging findings treatment colitis caused by Pythium insidiosum in a canine presenting haematochezia progressive weight loss. Through imaging, thickening transverse descending colon was observed. Histopathological analysis large intestine fragment revealed presence hyphae, confirmed immunohistochemistry PCR as P. insidiosum. Antifungal with itraconazole implemented after partial surgical resection, resulted...

Abstract Many medicinal plants are sought as alternative therapies for various conditions, opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of with therapeutic and properties. One them is copaiba oil, natural product the biodiversity Amazon. anti-inflammatory antimicrobial properties oil have been drawing attention scientific community great in treatment illnesses associated inflammatory infectious processes. purpose present study evaluate analyze latest...

Background: Dioctophimosis is a parasitic disease caused by Dioctophyma renale, more commonly known as "giant Kidney worm," and can be found in other organs or free the abdominal cavity, which related to patient's eating habits. Most of animals affected are asymptomatic. The diagnosis made through ultrasonography, finding eggs parasite urine, necropsy. treatment choice nephrectomy kidney. We aimed report accidental parasitism D. renale an 8-year-old dog, was surgically treated right kidney...

Os cuidados sanitários e o tratamento de patologias em animais silvestres têm sido pauta muitos estudos ganhado bastante importância pesquisas inovações científicas. Este trabalho tem como objetivo relatar cirúrgico uma fratura completa rádio ulna um tamanduá-bandeira, espécie esta ameaçada extinção, atropelado numa rodovia próxima a matas que sofriam queimadas, no norte do estado Mato Grosso/Brasil. O animal silvestre foi atendido pelo Serviço Cirurgia veterinária Hospital Veterinário da...