A5066686033- Alzheimer's disease research and treatments
- Listeria monocytogenes in Food Safety
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Cardiac Structural Anomalies and Repair
- Vibrio bacteria research studies
- Cholinesterase and Neurodegenerative Diseases
- Escherichia coli research studies
- Mechanical Circulatory Support Devices
- Bacterial Infections and Vaccines
- Parkinson's Disease Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Microbial Inactivation Methods
University of Bern
2018-2025
University Hospital of Bern
2025
Laboratoire de Radiopharmaceutiques Biocliniques
2024
Université Grenoble Alpes
2014-2023
Inserm
2014
Phage therapy is being reconsidered as a valuable approach to combat antimicrobial resistance. We recently established personalized phage pipeline in healthy volunteers, where therapeutic phages were isolated from individuals' skin microbiota. In this study, we aim validate end-stage heart failure patients supported by left ventricular assist devices (LVADs), focusing on targeting Staphylococcus epidermidis, common pathogen responsible for LVAD infections. Over 2.5-year period, 45...
Listeria monocytogenes is a foodborne pathogen that causes abortion, septicemia, gastroenteritis and central nervous system (CNS) infections in ruminants humans. L. strains mainly belong to two distinct phylogenetic groups, named lineages I II. In general, clinical cases humans animals, particular CNS infections, are caused by lineage strains, while most of the environmental food Little known about why more virulent than II, even though various molecular factors mechanisms associated with...
Abstract Background Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation pathology Alzheimer’s disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 novel radiotracer for efficient detection and longitudinal monitoring species human brain. Methods The development production involved llama immunization with largest isoform oligomers different maturation states. Subsequently, underwent comprehensive vitro characterization...
Listeriosis is a severe disease caused by the opportunistic bacterial pathogen Listeria monocytogenes (L. monocytogenes). Previous studies indicate that of four phylogenetical lineages known, lineage I strains are significantly more prevalent in clinical infections than environment. Among 1, sequence type (ST1) belongs to most frequent genotypes and behaves hyperinvasive experimental vitro compared II suggesting yet uncharacterized virulence genes contribute high certain strains. This study...
Previous works have shown the interest of naturally fluorescent proflavine derivatives to label Abeta deposits in vitro. This study aimed further characterize properties 3-acetylamino-6-[3-(propargylamino)propanoyl]aminoacridine (COB231) derivative as a probe. compound was therefore evaluated on human post-mortem and mice brain slices vivo 18-month-old triple transgenic APPswe, PS1M146V tauP301L (3xTgAD) presenting main characteristics Alzheimer's disease (AD). COB231 labelled amyloid...
Abstract Background Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation pathology Alzheimer’s disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 novel radiotracer for efficient detection and longitudinal monitoring species human brain. Methods The development production involved llama immunization with largest isoform oligomers different maturation states. Subsequently, underwent comprehensive vitro characterization...