A5083606959- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Alzheimer's disease research and treatments
- Radioactive element chemistry and processing
- Autoimmune Neurological Disorders and Treatments
- Glioma Diagnosis and Treatment
- Mass Spectrometry Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Medical Imaging and Pathology Studies
- Cardiovascular Function and Risk Factors
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Medical Device Sterilization and Disinfection
- Angiogenesis and VEGF in Cancer
- Artificial Intelligence in Healthcare and Education
- Orthopaedic implants and arthroplasty
Université Grenoble Alpes
2018-2025
Centre Hospitalier Universitaire de Grenoble
2019-2025
Inserm
2018-2025
Laboratoire de Radiopharmaceutiques Biocliniques
2018-2023
Assistance Publique Hôpitaux de Marseille
2021
Hôpital Albert Michallon
2021
39 Background: To assess the prognostic value of post-therapy [ 177 Lu]Lu-PSMA (LuPSMA)-SPECT/CT by visual RECIP 1.0 during LuPSMA radioligand therapy and to develop an evidence-based clinical protocol monitor efficacy LuPSMA. Methods: Patients who received between April 2019 November 2023 underwent at least two LuPSMA-SPECT/CT (SPECT) were included. Three independent readers interpreted pairs baseline interim after 2 cycles for Response Evaluation Criteria In PSMA-imaging (RECIP) 1.0. The...
Air pollution contributes to cardiovascular morbimortality. effects on function assessed from non-invasive and invasive imaging have been reported but never myocardial perfusion. This study aimed characterize relations of air exposure perfusion (MPI). Patients referred SPECT (single-photon emission computed tomography) MPI were prospectively enrolled between 2017 2020. Myocardial ischemia was the SPECT. Moderate-to-severe defined as a > 10 % ischemic myocardium. Exposures particulate matter...
Abstract Background Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation pathology Alzheimer’s disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 novel radiotracer for efficient detection and longitudinal monitoring species human brain. Methods The development production involved llama immunization with largest isoform oligomers different maturation states. Subsequently, underwent comprehensive vitro characterization...
(1) Background: As outcome of patients with metastatic melanoma treated anti-PD1 immunotherapy can vary in success, predictors are needed. We aimed to predict at the patients' levels, overall survival (OS) and progression-free (PFS) after one year immunotherapy, based on their pre-treatment 18F-FDG PET; (2) Methods: Fifty-six patients-without prior systemic treatment-were retrospectively included. Forty-five PET-based radiomic features were computed top five associated patient's selected....
Our aim was to analyse whether biomarkers extracted from baseline 18F-FDG PET before anti-PD1 treatment contribute prognostic survival information for early risk stratification in metastatic melanoma. Fifty-six patients, without prior systemic treatment, BRAF wild type, explored using were included retrospectively. primary endpoint overall (OS). Total metabolic tumoral volume (MTV) and forty-one IBSI compliant parameters PET. Parameters associated with outcome evaluated by a cox regression...
Introduction [ 18 F]fluorodeoxyglucose ([ F]FDG) brain PET is used clinically to detect small areas of decreased uptake associated with epileptogenic lesions, e.g., Focal Cortical Dysplasias (FCD) but its performance limited due spatial resolution and low contrast. We aimed develop a deep learning-based image enhancement method using simulated improve lesion visualization. Methods created 210 numerical phantoms (MRI segmented into 9 regions) assigned 10 different plausible activity values...
To assess whether whole-body (WB) bone SPECT/CT provides additional diagnostic information over [18F]-FCH PET/CT for the detection of metastases in setting prostate cancer biochemical recurrence (PC-BR).Patients referred a PC-BR and whom benefited from WB FCH were retrospectively included. Tests classified as positive, equivocal, or negative metastases. A best valuable comparator (BVC) strategy including imaging follow-up data was used to determine metastatic status absence systematic...
We report herein the case of an 80-year-old man who was referred for a biochemical recurrence high-risk prostate cancer. In addition to cancer recurrence, F-choline allowed partial initial staging incidental diffuse large B-cell lymphoma which further confirmed and staged using F-FDG biopsy. Two types metabolic behavior were therefore identified corresponded 2 different uptake patterns, that is, those tumoral cell contingents.
Abstract We report herein the case of a 33-year-old woman who was referred for FDG PET/CT staging prior to pregnancy after 4-year lost follow-up breast invasive ductal carcinoma (pT2N1 SBRII). revealed right supraclavicular lymphadenopathy potentially caused by recurrence. No additional site involved. Supraclavicular ultrasonography showed typical “snowstorm” appearance. MRI signs implant intracapsular rupture and signal intensity silicone within node. Fine-needle aspiration microbiopsy...
Recent progress in breast cancer research has led to the identification of Vascular Cell Adhesion Molecule-1 (VCAM-1) as a key actor metastatic colonization. VCAM-1 promotes lung-metastases and is associated with clinical early recurrence poor outcome triple negative (TNBC). Our objective was perform vivo imaging mice models TNBC. The Cancer Genomic Atlas (TCGA) database analyzed evaluate prognostic role MDA-MB-231 (VCAM-1+) control HCC70 (VCAM-1-) TNBC cells were subcutaneously xenografted...
ABSTRACT Background Parkinson’s disease (PD) diagnosis relies on motor symptoms such as akinesia, rigidity, and tremor, which manifest late in the course, contributing to delayed diagnosis. However, cognitive, limbic manifestations may precede symptoms, offering an earlier diagnostic opportunity, but their early kinetics require further characterization. Although high frequency deep brain stimulation (DBS) of subthalamic nucleus (STN) significantly improves it does not specifically address...
Background: Machine learning (ML) models based on radiomics analysis of amino-acid positron emission tomography (PET) images have demonstrated efficiency in predicting the histomolecular diagnosis gliomas. However, clinical validation these methods for physician interpretation remains challenging. This study aimed to investigate whether an explainable model impacts nuclear physicians' aggressiveness presumed gliomas at diagnosis.Methods: Patients underwent dynamic 6-[18F]fluoro-L-DOPA PET...
The aim of this brief communication is to highlight the potential bacteriological risk linked processes control radiopharmaceutical preparations made in a radiopharmacy laboratory. Survival rate Pseudomonas aeruginosa (ATCC: 27853) or Staphylococcus aureus 25923) epidermidis 1228) multidose technetium-99 m solution was studied.Depending on nature and level contamination by pathogenic bacteria, lethal effect radioactivity not systematically observed. We found that P. indeed affected...
Prostate Specific Membrane Antigen (PSMA) is a highly relevant target in nuclear medicine due to its overexpression prostate cancer. The 68Ga/177Lu-PSMA-1 combination theranostic agent for the detection and treatment of tumors overexpressing PSMA target. Specifically, 177Lu-PSMA-1 used castration-resistant cancer that ineffective or intolerant latest generation chemotherapy and/or hormone therapy. This radiopharmaceutical manufactured synthesizing unit must pass quality control where...
Abstract Prostate cancer bone metastases usually appear as osteosclerotic lesions. However, atypical lesions have also been described. We report herein the case of a 65-year-old man treated since 2013 for prostate with early metastases. This asymptomatic patient was referred 18 F-choline PET/CT due to major elevation prostate-specific antigen >1500 ng/mL. The results indicated multiple lesions, disseminated on axial skeleton, girdles, and upper extremities femurs. Interestingly, we...
Despite the development of positron emission tomography (PET), single photon computed (SPECT) still accounts for around 80% all examinations performed in nuclear medicine departments. The search new radiotracers or chelating agents Technetium-99m is therefore ongoing. O-TRENSOX and O-TRENOX two synthetic siderophores would be good candidates this purpose as they are hexadentate ligands based on very versatile efficient 8-hydroxyquinoline subunit. First, radiolabeling with 99mTc was...