Abstract Observations highlight the complex tectonic, magmatic, and geodynamic phases of Cenozoic post-collisional evolution Himalayan-Tibetan orogen show that these migrate erratically among terranes accreted to Asia prior Indian collision. This behavior contrasts sharply with expected large, hot orogens formed by collision lithospheres laterally uniform properties. Motivated this problem, we use two-dimensional numerical geodynamical model experiments enigmatic orogeny can result from...

Abstract This paper presents the development of an origami-inspired support system (the OriGuide) that enables insertion flexible instruments using medical robots. Varying parameters a triangulated cylindrical origami pattern were combined to create effective highly compressible anti-buckling maintains constant inner diameter for supporting instrument and outer throughout actuation. The proposed is composed two repeated patterns: bistable points mitigate shaft buckling monostable enable...

Abstract Adenosine is a purine nucleoside with immunosuppressive activity that acts through cell surface receptors (A1, A2a, A2b, A3) on responsive cells such as T lymphocytes. IL-2 major growth and survival factor responsible for inducing Jak1, Jak3, STAT5 phosphorylation, well causing to translocate the nucleus bind regulatory elements in genome. In this study, we show adenosine suppressed IL-2-dependent proliferation of CTLL-2 by inhibiting STAT5a/b tyrosine phosphorylation associated...

Abstract Building on our previous results, we use 2‐D upper mantle‐scale thermomechanical numerical models to explore key controls the evolution of Alpine‐type orogens and Alps per se, focusing (ultra)high‐pressure ((U)HP) metamorphic rocks. The show that UHP rocks form exhume by burial subsequent buoyant ascent continental crust in subduction conduit. Here test sensitivity surface erosion rate, crustal heat production, plate convergence/divergence rates, geometry subducting margin, strength...

Recently, there has been an increased interest in endowing intelligent behaviors and features soft robotic systems. As a prerequisite for intelligence, system must integrate sensing, information processing, the ability to act response external stimuli. This work presents crawler that demonstrates locomotion using electroactive liquid crystal elastomers (LCEs). By integrating independent components such as photo-responsive LCE switch into conductive electromechanical processing network based...

Abstract Adenosine, a purine nucleoside found at high levels in solid tumors, is able to suppress the recognition/adhesion and effector phases of killer lymphocyte‐mediated tumor cell destruction. Here, we demonstrate that adenosine, concentrations are typically present extracellular fluid exerts profound inhibitory effect on induction mouse cytotoxic T cells, without substantially affecting T‐cell viability. proliferation response mitogenic anti‐CD3 antibody was impaired presence 10 μM...

Abstract Ultrahigh‐pressure (UHP) rocks from the Western Gneiss Region (WGR) of Norway record subduction Baltican continental crust during Silurian to Devonian Scandian collision. Here, we report a new coesite locality island Harøya in Nordøyane UHP domain, most northerly yet documented WGR, and reconstruct P–T history host eclogite. The coesite–eclogite lies within migmatitic orthogneiss, interpreted as Baltica basement, that underwent multiple stages deformation partial melting exhumation....

The design and testing of a highly compressible origami bellows for harsh environments is described. Several patterns are evaluated the Kresling fold pattern was customized to constraints selected use in design. Origami were prototyped five different materials tested fatigue, thermal cycling, ablation, radiation. Tested show good fatigue life exceeding 100,000 cycles some resilience potential environmental conditions such as abrasion, high can be designed fit within given inner outer...

Abstract Adenosine is an immunosuppressive molecule that associated with the microenvironment of solid tumors. Mouse T cells activated anti‐CD3 antibody in presence adenosine or without coformycin (to prevent breakdown by deaminase) exhibited decreased tyrosine phosphorylation some intracellular proteins and were inhibited their ability to proliferate synthesize interleukin (IL)‐2. In addition, interfered activation‐induced expression co‐stimulatory molecules CD2 CD28. Activation‐induced...

Abstract (Ultra)high-pressure [(U)HP] rocks form and exhume from deep within subduction channels, but subsequent horizontal transport in the shallower orogenic crust makes it difficult to reconstruct their tectonic histories. We use a conceptual framework numerical models show that buoyant exhumation conduit formed during one-sided may lead emplacement of (U)HP into either lower plate (prowedge) or upper (retrowedge) an orogen, depending on whether deforms acts as backstop exhumation. Both...

Subduction and exhumation of ultrahigh-pressure (UHP) metamorphic terranes are typically envisaged as short-lived processes associated with the transition from oceanic subduction to continent-continent collision. Norway's Western Gneiss Region, by comparison, is a giant, late-orogenic UHP terrane that underwent protracted residence at conditions during Scandian phase Caledonian orogeny followed relatively slow exhumation. Here, we use two-dimensional numerical thermal-mechanical models...

Mechanical advantage is traditionally defined for single-input and single-output rigid-body mechanisms. A generalized approach identifying mechanical a multiple-input compliant mechanism, such as many origami-based mechanisms, would prove useful in predicting complex mechanism behavior. While mechanisms are capable of offering unique solutions to engineering problems, the design process complicated by interaction motion forces. This paper presents model multi-input explores how modifying...

Axial micromotion between bone fragments can stimulate callus formation and fracture healing. In this study, we propose a novel mechanically compliant locking plate which achieves up to 0.6 mm of interfragmentary motion as flexures machined into the elastically deflect under physiological load. We investigated biomechanical performance three variations in comparison rigid control plates with small large working lengths comminuted bridge plating scenario using humeral diaphysis surrogates....

The identification of genes associated with colonization and persistence Helicobacter pylori in the gastric mucosa has been limited by lack robust animal models that support infection strains whose genomes have completely sequenced. Here we report an interleukin-12 (IL-12)-deficient mouse (IL-12(-/-) p40 subunit knockout C57BL/6 mouse) is permissive for a motile variant (KE88-3887) Institute For Genomic Research-sequenced strain (KE26695) H. pylori. IL-12-deficient was also more...

Abstract Metamorphic soles found under allochthonous oceanic lithosphere, or ophiolites, are interpreted as derived from lower plate crust material accreted to upper mantle during intraoceanic subduction initiation. Their metamorphic evolution is inferred reflect the thermal structure at site of nucleation, with granulite-bearing linked initiation hot spreading centers. Here we present garnet Lu-Hf geochronology for sole Xigaze ophiolite in South Tibet, whose formed ∼130 Ma through...

Maintaining hand hygiene has been an essential preventive measure for reducing disease transmission in public facilities, particularly during the COVID-19 pandemic. The large number of sanitizer stations deployed within such as on university campuses, brings challenges effective facility management. This paper proposes IoT sensor network tracking usage facilities and supporting management using a data-driven approach. Specifically, system integrates low-cost wireless sensors, LoRaWAN,...

Abstract The regional sandwiching of compliant sheets (ReCS) technique presented in this work creates flat-foldable, rigid-foldable, and self-deploying thick origami-based mechanisms. Regional the sheet is used to create mountain-valley assignments for each fold about a vertex, constraining motion single branch folding. Strain energy deflected flexible members enable self-deployment. This presents methods design mechanisms using ReCS technique, including volume trimming at vertex panels...

Arc magmatism along convergent plate boundaries has been a major contributor to continental crustal growth. During the late Paleoproterozoic−Mesoproterozoic assembly of supercontinent Nuna, following arc-backarc-continent collisions, Makkovik Orogen, southern margin Archean North Atlantic Craton, experienced pulse arc at ca. 1800 Ma. Lithogeochemistry indicates compositions typical ferroan, alkali alkali-calcic, A-type granites. The granitic rocks have εNd(t) values varying from −5.3 +2.0...

Abstract A novel flexure-based compliant bone plate is proposed for long fracture compression. Locking screws can be used in all screw holes while compression generated through pretensioning of flexible elements the plate. Performance differences are characterized use both titanium alloy and stainless steel Biomechanical simulations performed with finite element analysis to determine surface characteristics. The plating technology may offer unique benefits locked plating.