To compare test results from second-generation Frequency-Doubling Technology perimetry (FDT2, Humphrey Matrix; Carl-Zeiss Meditec, Dublin, CA) and standard automated (SAP) in patients with glaucoma. Specifically, to examine the relationship between visual field sensitivity test-retest variability total pattern deviation probability maps both techniques.Fifteen glaucoma who had early moderately advanced loss SAP (mean MD, -4.0 dB; range, +0.2 -16.1) were enrolled study. Patients attended...

Purpose.: To compare the properties of visual field index (VFI) to those mean deviation (MD) in patients with glaucoma. Methods.: MD and VFI were calculated data obtained from an ongoing longitudinal study which glaucoma (N = 109, 204 eyes) observed for 9.8 years (median, 21 tests) static automated perimetry. compared one test each eye, a subset 30 tests selected judgments eight experts who judged percentage remaining field. In series over time, rates change, statistical significance,...

To examine peripapillary choroidal thickness in healthy controls and patients with glaucoma who have focal, diffuse, sclerotic optic disc damage.Healthy (n=92) focal (n=34), diffuse (n=35), (n=34) damage were imaged spectral-domain optical coherence tomography (12° circular scan protocol centered on nerve head). Peripapillary was measured as the distance between automatically segmented retinal pigment epithelium/Bruch's membrane manually outlined interface posterior choroid anterior border...

Purpose.: To evaluate the structure–function relationship between disc margin–based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch's membrane opening–based horizontal width (BMO-HRW), minimum (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) spectral-domain optical coherence (SD-OCT), and visual field sensitivity. Methods.: We examined 151 glaucoma patients CSLT, SD-OCT, standard automated perimetry on same day. Optic head (ONH) RNFL SD-OCT...

Eight strains of Clostridium absonum were shown to form ursocholic acid (UC) from cholic (C) and ursodeoxycholic (UDC) chenodeoxycholic (CDC) but did not transform deoxycholic (DC) in whole cell cultures.T h e structures UC UDC verified by mass spectroscopy, thin-layer chromatography using Komarowsky's spray reagent.The organism transformed C CDC at concentrations below 1.5.M 5.0.M, respectively; higher inhibitory.Optimal yields the final products realized about 15-22 hr 9-15 incubation,...

A gram-positive, anaerobic, chain-forming, rod-shaped anaerobe (isolate G20-7) was isolated from normal human feces. This organism identified by cellular morphology as well fermentative and biochemical data Eubacterium aerofaciens. When isolate G20-7 grown in the presence of Bacteroides fragilis or Escherichia coli (or another 7 alpha-hydroxysteroid dehydrogenase producer) chenodeoxycholic acid, ursodeoxycholic acid produced. Time course curves revealed that 3 alpha-hydroxy-7-keto-5...

purpose. To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous changes. methods. Four expert observers first examined a training set of 40 pairs monoscopic photographs help criterion change. They then classified 44 patients followed prospectively as having either definitely no change, probably or change (score, 0, 1, 2, 3, respectively). Observers were unaware that 10 fellow eyes obtained the same day measure specificity. These...

<b>Aims:</b> To determine whether central corneal thickness (CCT) is a significant predictor of visual field and optic disc progression in open angle glaucoma. <b>Methods:</b> Data were obtained from prospective study glaucoma patients tested with static automated perimetry confocal scanning laser tomography every 6 months. Progression was determined using trend based approach called evidence change (EOC) analysis which sectoral ordinal scores on the significance regression coefficients...

Purpose.: To quantify and characterize the difference between automated manual segmentation of optic nerve head structures with spectral-domain optical coherence tomography (SD-OCT). Methods.: Optic radial scans in 107 glaucoma patients 48 healthy controls were conducted SD-OCT. Independent segmentations internal limiting membrane (ILM) Bruch's opening (BMO) performed manually custom software an algorithm each scan. The minimum distance BMO ILM, termed BMO–minimum rim width (BMO-MRW) was...

To compare the diagnostic accuracy of conventional sector-based analysis with a method devised to detect smallest localized neuroretinal rim and retinal nerve fiber layer thickness (RNFLT) damage.One eye 151 glaucoma patients 83 healthy controls (median age MD, 71.7 66.7 years, -3.6 -0.3 dB, respectively) was imaged spectral-domain optical coherence tomography (OCT). Bruch's membrane opening-minimum width (BMO-MRW) RNFLT were determined at 1° intervals also averaged for each sector. A...

The identification of genes associated with colonization and persistence Helicobacter pylori in the gastric mucosa has been limited by lack robust animal models that support infection strains whose genomes have completely sequenced. Here we report an interleukin-12 (IL-12)-deficient mouse (IL-12(-/-) p40 subunit knockout C57BL/6 mouse) is permissive for a motile variant (KE88-3887) Institute For Genomic Research-sequenced strain (KE26695) H. pylori. IL-12-deficient was also more...

To compare frequency-doubling technology (FDT) perimetry with standard automated (SAP) for detecting glaucomatous visual field progression in a longitudinal prospective study.One eye of patients open-angle glaucoma was tested every 6 months both FDT and SAP. A minimum examinations each perimetric technique required inclusion. Visual determined by two methods: change probability (GCP) analysis linear regression (LRA). For GCP, several criteria were used. The number locations to classify...

A fecal isolate, Streptococcus sp. strain FRP-17, and VGH-1 of faecium were shown to contain beta-glucosidases which converted rutin (quercetin-3-O-beta-D-glucose-alpha-L-rhamnose) quercetin active against o-nitrophenyl-beta-D-glucose. The activity could be measured by increased mutagenicity in the Ames assay or visualized on thin-layer chromatography plates. In both organisms, beta-glucosidase activities inducible addition growth media. Several closely related strains spp. lacked any...

A new analysis method called permutation of pointwise linear regression measures the significance deterioration over time at each visual field location, combines values into an overall statistic, and then determines likelihood change in field. Because outcome is a single P value, individualized to that specific independent scale original measurement, well suited for comparing techniques with different stimuli scales.To test hypothesis frequency-doubling matrix perimetry (FDT2) more sensitive...

Purpose: To compare the visibility of deep optic nerve head (ONH) structures and visible area anterior surface lamina cribrosa (ASLC) with spectral-domain optical coherence tomography (SD-OCT) swept-source OCT (SS-OCT). Materials Methods: In total, 33 glaucoma patients were imaged SD-OCT (Spectralis, 24 radial B-scans centered on ONH) SS-OCT (Atlantis, 12 a horizontal vertical raster scan pattern containing 5 lines each, ONH). One scans that was best matching those selected. All then...