A5051173903- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Blood donation and transfusion practices
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Microbial infections and disease research
- Travel-related health issues
- Hepatitis Viruses Studies and Epidemiology
- Vibrio bacteria research studies
- Medical Research and Treatments
- Hepatitis C virus research
- Erythrocyte Function and Pathophysiology
- Childhood Cancer Survivors' Quality of Life
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Prion Diseases and Protein Misfolding
- Malaria Research and Control
- RNA modifications and cancer
Swiss Red Cross
2019-2024
During the last few decades, efforts to increase safety of blood and products have mainly focused on preventing viral infections HCV, HIV, HBV Treponema pallidum. The evolution these approaches achieved in is shown for 25 years Switzerland. In detail, prevalences incidences infection disease theoretical estimated residual risks (RR) blood-borne are presented. Prevalences, and, particular, RR decreased considerably over years. This was primarily by adoption strict criteria selection donors,...
Results of genotyping with true high-throughput capability for MNSs antigens are underrepresented, probably because technical issues, due to the high level nucleotide sequence homology paralogous genes GYPA, GYPB and GYPE. Eight MNSs-specific single polymorphisms (SNP) were detected using matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry (MALDI-TOF MS) in 5800 serologically M/N S/s pre-typed Swiss blood donors 50 individuals known or presumptive black African...
Introduction: Hepatitis E virus (HEV) genotype 3 is the major cause of acute viral hepatitis in several European countries. It acquired mainly by ingesting contaminated pork, but has also been reported to be transmitted through blood transfusion. Although most HEV infections, including those via products, are usually self-limiting, they may become chronic immunocompromised persons. thus essential identify HEV-infected donations prevent transmission vulnerable recipients. Aims: Prior decision...
High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even >99% individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible is hardly found, and if patient carries alloantibodies, cross-match will be positive with virtual every red cell unit tested.In this study, we applied high-throughput SNP genotyping on >37,000 Swiss donors, intending identify homozygous carriers low-frequency...
Risk of transfusion-transmitted (TT) malaria is mainly associated with whole blood (WB) or red cell (RBC) transfusion. mitigation relies mostly on donor deferral while a limited number countries perform testing, both negatively impacting availability. This study investigated the efficacy pathogen reduction system using amustaline and glutathione (GSH) to inactivate Plasmodium falciparum in WB.WB units were spiked ring stage P. infected RBCs. Parasite loads measured samples at time infection,...
Background Interest in an effective pathogen reduction technology ( PRT ) for whole blood WB tailored to address specific needs of limited‐resource settings is growing. The Swiss Red Cross Humanitarian Foundation SRCHF supports a clinical programme promote resource‐limited where rates use and transfusion‐transmitted infections are high. Pathogen Cerus Corporation INTERCEPT ® Blood System) Terumo BCT (Mirasol investing trials red‐blood‐cell RBC . selected the its Africa based on data related...