A5034734893- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Genomics and Phylogenetic Studies
- Nuclear Structure and Function
- Birth, Development, and Health
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
- PARP inhibition in cancer therapy
- Metabolism and Genetic Disorders
- Adenosine and Purinergic Signaling
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Aquaculture disease management and microbiota
- Turtle Biology and Conservation
- Apelin-related biomedical research
- Polyamine Metabolism and Applications
Universidad de Oviedo
2017-2023
Centro de Investigación Biomédica en Red de Cáncer
2018
Dietary intervention constitutes a feasible approach for modulating metabolism and improving the health span lifespan. Methionine restriction (MR) delays appearance of age-related diseases increases longevity in normal mice. However, effect MR on premature aging remains to be elucidated. Here, we describe that extends lifespan two different mouse models Hutchinson-Gilford progeria syndrome (HGPS) by reversing transcriptome alterations inflammation DNA-damage response genes present this...
Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic molecular evolutionary information on giant is scarce. Here, we describe a global analysis of genomes Lonesome George-the iconic last member Chelonoidis abingdonii-and Aldabra tortoise (Aldabrachelys gigantea). Comparison these with those related species, using both unsupervised supervised analyses, led us detect...
Autophagy is a housekeeping catabolic process crucial for maintaining cell, tissue and organism functions. Through the years, study of animal models with tissue-specific inactivation autophagy essential genes has allowed us to understand its protective roles in context multiple human diseases, including cancer neurodegeneration. However, due nature autophagy, effects systemic inhibition mammals have not been explored detail. Here, we report generation ATG4A-only mice, simultaneously...
ATG4 (autophagy related 4 cysteine peptidase); ATG4A 4A ATG4B 4B ATG4C 4C ATG4D 4D Atg8 8); GABARAP (GABA type A receptor-associated protein); GABARAPL1(GABA protein like 1); GABARAPL2 2); MAP1LC3A/LC3A (microtubule associated 1 light chain 3 alpha); MAP1LC3B/LC3B beta); mATG8 (mammalian Atg8); PE (phosphatidylethanolamine); PS (phosphatydylserine); SQSTM1/p62 (sequestosome 1).