A5024922159- Medicinal Plants and Neuroprotection
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Biological and pharmacological studies of plants
- Healthcare and Venom Research
- Medicinal Plant Research
- Phytochemical Studies and Bioactivities
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Treatment and Research
- Chemokine receptors and signaling
- Hormonal and reproductive studies
- Sesquiterpenes and Asteraceae Studies
- Inflammatory mediators and NSAID effects
- Multiple Myeloma Research and Treatments
- Immune cells in cancer
Biotechnology Research Center
2023
Agricultural Biotechnology Research Center, Academia Sinica
2015-2017
National Taiwan University
2009
Academia Sinica
2009
Tri-Service General Hospital
2009
National Defense Medical Center
2009
Chaoyang University of Technology
2008
Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation involved promoting tumor growth, invasion, metastasis. This study aims to test the biological effects vivo W. extract on prostate cancer.The efficacy mechanisms action oral administration standardized were analyzed animals bearing subcutaneous or orthotopic cancer xenograft.Exposure cells induced apoptosis selectively androgen receptor (AR)-positive shifted proportion...
Activation of the NFκB pathway is often associated with advanced cancer and has thus been regarded as a rational therapeutic target. Wedelia chinensis rich in luteolin, apigenin, wedelolactone that act synergistically to suppress androgen receptor activity prostate cancer. Interestingly, our evaluation standardized herbal extract (WCE) concluded its efficacy on hormone-refractory through systemic mechanisms. Oral administration WCE significantly attenuated tumor growth metastasis orthotopic...
Crosstalk between the androgen receptor (AR) and other signaling pathways in prostate cancer (PCa) severely affects therapeutic outcome of hormonal therapy. Although anti-androgen therapy prolongs overall survival PCa patients, resistance rapidly develops is often associated with increased AR expression upregulation HER2/3-AKT pathway. However, single agent targeting AR, HER2/3 or AKT usually fails due to reciprocal feedback loop. Previously, we reported that wedelolactone, apigenin,...
Supplementary Data from Herbal Extract of <i>Wedelia chinensis</i> Attenuates Androgen Receptor Activity and Orthotopic Growth Prostate Cancer in Nude Mice
<div>Abstract<p><b>Purpose:</b> <i>Wedelia chinensis</i> is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation involved promoting tumor growth, invasion, metastasis. This study aims to test the biological effects <i>in vivo</i> <i>W. extract on prostate cancer.</p><p><b>Experimental Design:</b> The efficacy mechanisms action oral administration standardized were...
<div>Abstract<p><b>Purpose:</b> <i>Wedelia chinensis</i> is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation involved promoting tumor growth, invasion, metastasis. This study aims to test the biological effects <i>in vivo</i> <i>W. extract on prostate cancer.</p><p><b>Experimental Design:</b> The efficacy mechanisms action oral administration standardized were...
Supplementary Data from Herbal Extract of <i>Wedelia chinensis</i> Attenuates Androgen Receptor Activity and Orthotopic Growth Prostate Cancer in Nude Mice