A5020887439- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Radiopharmaceutical Chemistry and Applications
- Metal complexes synthesis and properties
- Asymmetric Hydrogenation and Catalysis
- Boron Compounds in Chemistry
- Chemical Synthesis and Analysis
- Magnetism in coordination complexes
- Various Chemistry Research Topics
- Catalytic Cross-Coupling Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Carbon dioxide utilization in catalysis
- Radioactive element chemistry and processing
- Science Education and Pedagogy
- Ferrocene Chemistry and Applications
- Sinusitis and nasal conditions
- Computational Drug Discovery Methods
- Crystal structures of chemical compounds
- Organic and Molecular Conductors Research
- Innovative Teaching Methods
- Chemical Synthesis and Reactions
- DNA and Nucleic Acid Chemistry
Nanyang Technological University
2009-2024
National University of Singapore
1991-2018
Tianjin University of Science and Technology
2018
National University Health System
2018
Yanbian University of Science and Technology
2018
National Institute of Education
2000-2014
National Institute of Education Sciences
2014
In-Q-Tel
2010-2011
University of Edinburgh
2005-2006
Technical University of Munich
1999
Group 7−12 transition-metal complexes serve as effective catalysts for the regioselective intramolecular hydroamination of aminoalkynes having general formula RC⋮C(CH2)nNH2 (n = 3, R H, Ph; n 4, H) and 2-(phenylethynyl)aniline. Primary products are pyrrolidines piperidines bearing an α-alkylidene functionality 2-phenylindole, respectively. Isomerization yields corresponding pyrrolines 1,2-dehydropiperidines. The catalytic properties depend on appropriate choice ligand, solvent, temperature,...
In this paper, we define flip teaching as a curricular platform that uses various strategies, tools, and pedagogies to engage learners in self-directed learning outside the classroom before face-to-face meetings with teachers classroom. With understanding, adopted design enactment of one Year 1 2 undergraduate chemistry laboratory session at higher education institution. The undergraduates viewed videos demonstrating practical procedures answered pre-laboratory questions posted on...
The IL-13 receptor α2 (IL-13Rα2) is a for which has conflicting roles in mediating responses the lower airway, with little known about its impact on upper airway diseases. We sought to investigate expression of receptors, IL-13Rα1 and IL-13Rα2, chronically inflamed nasal epithelium, explore IL-13-induced signaling pathways an vitro model human epithelial cells (hNECs).The protein mRNA levels receptors biopsies patients polyps (NP) healthy controls were evaluated. investigated goblet cell...
This study focused on grade 12 students’ understanding of reaction kinetics. A 4-tier diagnostic instrument was developed for this purpose and administered to 137 students in the main study. Findings showed that kinetics is a difficult topic these students, with total 25 alternative conceptions (ACs) being uncovered. Except one AC, other ACs uncovered have not been reported before literature. An interesting point emerging from nearly 70% were obtained questions featured graphs. Overall,...
A series of substituted salicylaldehyde dibenzyl semicarbazones [RC6H3(OH)CH=N-NHCON(CH2Ph)2] and their copper(II) complexes were synthesized characterized. The chloridocopper(II) the 4-OH 5-OH ligands (complexes 9 7) show modest affinity good selectivity (over duplex DNA) for quadruplex formed from human telomeric (HTelo) DNA sequence. Substitution chlorido these two with pyridine yielded derivatives (7-py 9-py) increased HTelo. These also HTelo over calf-thymus (170- 211-fold,...
A facile and convenient strategy for the assembly of N-arylated heterocycles has been demonstrated using a MnCl2·4H2O/trans-1,2-diaminocyclohexane catalyst K3PO4 as base in water.
The copper(ii) complexes of two salicylaldehyde semicarbazones, HOC(6)H(4)CH[double bond, length as m-dash]N-NHCONR(2) [H(2)Bnz(2) (R = CH(2)Ph) and H(2)Bu(2) Bu)], were evaluated for their DNA binding cleavage properties by spectrophotometric titration, ethidium bromide displacement assay electrophoretic mobility shift assay. Results showed that the Cu(ii) can bind to via a partial intercalation mode with constants 1.1 × 10(4) 9.5 10(3) M(-1) [Cu(HBnz(2))Cl] [Cu(HBu(2))Cl], respectively....
The in vitro cytotoxic studies of a series salicylaldehyde semicarbazones, HOC6H4CH˭N–NHCONR2 (H2R2) and their Cu(ii) complexes on number human tumor cell lines were conducted it was observed that cytotoxicities enhanced following complexation to copper. These copper(ii) also demonstrated higher activities than the reference drug, cisplatin, at micro molar range. Apoptotic assays cycle analysis copper complexes, [Cu(HBnz2)Cl] [Cu(HBu2)Cl] revealed they mediated cytotoxicity MOLT-4 cells via...
The sandwich complex commo-[3,3′-Fe{4-(Me2S)-1,2-C2B9H10}2]1 was synthesised. Its meso and DD/LL isomers are easily separated by fractional recrystallization from acetone were spectroscopically characterized. charge-transfer salt [3,3′-Fe{4-(Me2S)-1,2-C2B9H10}2]+[ddq]˙–2 formed between the DD/LL-1 racemate 2,3-dichloro-5,6-dicyano-p-benzoquinone (ddq). X-Ray crystallography revealed an increase in iron-dicarbollide distance on oxidation of DD/LL-1(Fe–C2B3 1.50 Å) to cation 2(Fe–C2B3 1.54 Å)....
We hypothesized that gene expression and fatty acid composition would differ among different muscle depots over time on a grain-based finishing diet. Additionally, we the concentration of SFA decrease MUFA increase proportionately with increases in percent intramuscular lipid (%IML). Ten Yanbian Yellow cattle steers (approximately 8 mo age) were fed corn-based diet which proportion corn ration was increased at 4-mo intervals. Muscle samples taken by biopsy from chuck (trapezius), loin...
The complexes [Re2(μ-OR)2(μ-dppf)(CO)6] (R = H, 1; Me, 2; Et, 3; Ph, 4) were synthesized by the controlled acidolysis of anions [Re2(μ-OR)3(CO)6]- Et) and [Re2(μ-OH)(μ-OPh)2(CO)6]- (5), respectively, in presence dppf (1,1'-bis(diphenylphosphino)ferrocene). ligands 1−4 undergo a twisting motion solution at room temperature, which, case 3, is correlated with restricted rotation ethyl groups about O−CH2 bonds. Complex 3 an interesting example organometallic complex which two exchanging...
Copper complexes with potent anti-tumor effect have been extensively developed. Most investigations of their modes action focused on the biomolecular targets but not signal transduction between target binding and cell death. We previously shown that cytotoxic complex pyridine(2,4-dihydroxybenzaldehyde dibenzyl semicarbazone)copper(II) (complex 1) shows selective to human telomeric G-quadruplex DNA over double-stranded in vitro. Herein, we elucidate mechanism by which 1 induces apoptosis...