A5100385455- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Blood groups and transfusion
- T-cell and B-cell Immunology
- Reproductive tract infections research
- Maternal and Perinatal Health Interventions
- interferon and immune responses
- Blood transfusion and management
- Bacteriophages and microbial interactions
- NF-κB Signaling Pathways
- Global Maternal and Child Health
- Maternal Mental Health During Pregnancy and Postpartum
- Occupational and environmental lung diseases
- Prostate Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Herpesvirus Infections and Treatments
- Reproductive Health and Contraception
- Whipple's Disease and Interleukins
- Cell Adhesion Molecules Research
- 3D Modeling in Geospatial Applications
- Pancreatitis Pathology and Treatment
- Ectopic Pregnancy Diagnosis and Management
Henan University
2024
Tongji University
2020-2023
Shanghai Tenth People's Hospital
2020-2023
Hunan Provincial People's Hospital
2023
Dahua Hospital
2022
Union Hospital
2019-2021
Huazhong University of Science and Technology
2019-2021
Suzhou Municipal Hospital
2019
Nanjing Medical University
2019
Wuhan University
2018
3017 Background: B7-H3, a member of the B7 superfamily, is highly expressed in various solid tumors, but has limited expression at low level normal tissues. HS-20093 B7-H3-targeted antibody-drug conjugate. It could be an attractive therapeutic option for advanced especially patients (pts) who have failed multi-line therapy requiring novel and more effective treatment. Methods: This first-in-human, multicenter, open-label phase 1 study tumors (NCT05276609). Dose escalation part assessed...
A comprehensive analysis of the molecular mechanism underlying colorectal tumor evaluated development cancer (CRC) and proposed targeting small inhibitors. Nonetheless, adoptive resistance these therapies remains a challenge with respect to achieving an effective clinical response. Thus, identifying mechanisms guiding CRC growth is essential. The results Cancer Genome Atlas (TCGA) dataset demonstrated critical role signal transducer activator transcription 3 (STAT3) pathway in immune...
This article reported the mechanism of Anlotinib in gastric cancer treatment. Gastric cells were treated with (8 μM) and transfected by STING shRNA vectors. Cell counting kit-8 assay, wounding healing Transwell experiment applied for proliferation, migration, invasion detection. PD-L1 fluorescence intensity was explored flow cytometry. IFN-β level researched enzyme-linked immunosorbent reaction. Xenograft tumor performed administering mice anti-PD-L1 antibody. Immunohistochemistry western...
Background Less than 20% of melanoma patients respond to programmed cell death-1 (PD-1) blockade immunotherapies. Thus, it is crucial understand the dynamic changes in tumor microenvironment (TME) after PD-1 blockade, for developing immunotherapy efficacy. Methods A genomic analysis was conducted by The Cancer Genome Atlas (TCGA) datasets and web platform TIMER2.0 datasets. Pathway enrichment performed using Kyoto Encyclopedia Genes Genomes (KEGG) pathway. Peripheral blood mononuclear cells...
Abstract Galectin‐3 plays an important role in cell‐cell adhesion, macrophage activation, angiogenesis, metastasis and apoptosis is overexpressed pancreatic cancer. We explored the importance of galectin‐3 screening, early diagnosis, prognosis therapeutic effect evaluation A time‐resolved fluorescence immunoassay was performed to detect serum level. Serum samples were collected from healthy controls patients with cancer before after different treatments, relationships between level clinical...
Background Postpartum visits (PPVs) have been advocated as a way to improve health outcomes for mothers and their infants, but the rate of PPVs is still low in rural China. This study aims investigate utilization explore factors associated with Parity most concerned factor this study. Methods A cross-sectional household survey was performed two counties Zhejiang province. Questions include socio-economic, services women's delivery data. Chi-square tests multivariate logistic regression...
Previous studies have revealed that upregulation of interleukin 15 receptor α (IL15RA) contributes to improved prognosis breast cancer. The present study aimed elucidate the molecular mechanisms underlying antitumor effect induced by IL15RA upregulation, and identify a gene signature capable predicting survival patients with Using paired expression methylation data cancer samples from Cancer Genome Atlas portal, differentially expressed genes (DEGs) were identified in hypermethylated...
Nearly 350 million persons worldwide are chronically infected with hepatitis B virus (HBV). Ubiquitin (Ub) is a highly conserved small regulatory protein, ubiquitous in eukaryotes, that usually serves as signal for the target protein recognised and degraded proteasomes . The Ub-mediated processing of antigens rapid efficient stimulates cell-mediated immune responses. Accordingly, has been widely used chronic-infection cancer studies to improve response.Many clinical trials have shown DNA...
Parental occupational exposures might affect childhood cancer in the offspring through genetic changes ovum or sperm transplacental carcinogenesis. The 24 published epidemiologic studies of this association have all used case-control designs, with controls generally selected from birth certificates general population sampling. Occupational were inferred job titles on interviews. A large number occupation-cancer associations been reported, many which not addressed confirmed other studies....
Objectives: To investigate the psychological predictors in Chinese multiparous pregnant women of advanced maternal age (AMA) for choosing aneuploidy screening or diagnostic testing.Methods: A total 84 AMA were consecutively enrolled from Renming Hospital, Wuhan University. All participants completed three questionnaires: Zung Self-Rating Anxiety Scale (SAS), Depression (SDS), and Pregnancy Stress Rating (PSRS). Demographic information choice noninvasive prenatal testing (NIPT) versus...
How to choose an appropriate method monitoring dynamic ABO chimera post-ABO-incompatible HSCT is crucial not only assess the status of erythroid engraftment but also achieve personalized safety transfusion.We evaluated efficacy micro gel column technique (MGCT) and flow cytometry (FCM) by series artificial mixtures from 0.5% 50% investigating 15 cases ABO-incompatible patients with longitudinally blood grouping RBCs reticulocytes.5% 2% can be efficiently detected MGCT FCM, respectively. 6.3%...
Abstract In recent years, the rapid advancement of Building Information Modeling (BIM) technology has led to an increasing variety application scenarios, necessitating diverse demands on technology. Among these requirements, lightweighting BIM models is paramount importance. However, conventional approaches primarily focus themselves, neglecting varying needs users. This study presents a novel method for models, starting from user interests or specific scenario requirements. It employs...
HLA-DQB1*04:74 differs from HLA-DQB1*04:01:01:01 by one nucleotide substitution in codon 54 exon 2.
HLA‐C*03:466 differs from HLA‐C*03:04:01:01 by one nucleotide substitution in codon 280 exon 5.
The complete mitochondrial sequence of the redeye mullet Liza haematocheila has been determined. circle genome is 16,822 bp in size, and consists 13 protein-coding genes, 2 rRNA 22 tRNA genes a control region. gene order composition L. was similar to that most other teleosts. base H-strand 26.42% (A), 26.38% (T), 16.72% (G) 30.47% (C), with an AT content 52.8%. All are encoded on heavy strand exception ND6 eight genes. presented will be favor resolving phylogenetic relationships within...
Background: To explore the predictive value of venous cord blood neutrophil-to-lymphocyte ratio (NLR) and platelet to lymphocyte (PLR) for Early-onset sepsis (EOS) in preterm infants. Methods: A prospective cohort neonates with gestational ages <32 weeks a single hospital from January 2017 2020 were enrolled. Multivariable logistic regression was used determine independent risk factors EOS. ROC curves created estimate capacity. Results: total 427 included study. 176 exposed...