A5017996337- Hippo pathway signaling and YAP/TAZ
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Wnt/β-catenin signaling in development and cancer
- Fungal Infections and Studies
- Histone Deacetylase Inhibitors Research
- Pharmacovigilance and Adverse Drug Reactions
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- Gastrointestinal disorders and treatments
- Pharmacy and Medical Practices
- Cellular Mechanics and Interactions
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Extracellular vesicles in disease
- Tuberculosis Research and Epidemiology
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Parasitic Infections and Diagnostics
Nagoya City University
2021-2024
Aichi Cancer Center
2021-2024
Abstract Background Invasive fungal infections (IFIs) represent a potentially fatal complication in patients who undergo allogeneic hematopoietic stem cell transplantation (HSCT) if the initiation of therapy is delayed. Some guidelines recommend antifungal prophylaxis or preemptive for these depending on risk IFIs following HSCT. This retrospective study aimed to identify group safely HSCT with low‐dose fluconazole (FLCZ) (100 mg/day). Methods We retrospectively reviewed 107 underwent their...
Reoccurring/high-risk neuroblastoma (NB) tumors have the enrichment of non-RAS/RAF mutations along mitogen-activated protein kinase (MAPK) signaling pathway, suggesting that activation MEK/ERK is critical for their survival. However, based on preclinical data, MEK inhibitors are unlikely to be active in NB and demonstrated dose-limiting toxicities limit use. Here, we explore an alternative way target MAPK pathway high-risk NB. We find models among most sensitive over 900 tumor-derived cell...
Although tyrosine kinase inhibitors (TKIs) targeting EGFR-activating mutations significantly improved the outcome of EGFR-mutant NSCLC, resistance inevitably emerges. Despite heterogeneity these mechanisms, many induce activation MAPK signaling in presence EGFR-TKIs. While
Indoleamine 2,3-dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to kynurenine (Kyn), is important microenvironmental factor suppressing antitumor immunity. Here, we investigated the clinical impact of aberrant Trp metabolism in patients with multiple myeloma (MM) treated lenalidomide (Len) and evaluated its effects on T cell immunity ex vivo. Kyn concentrations were quantified sera from 72 relapsed or refractory MM prior initiation therapy Len plus dexamethasone (Ld)....
Abstract A 15‐year‐old male was diagnosed with acute myeloid leukemia t(6;9)(p23;q34), a chimeric DEK ‐ NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple aspirations showed increased blasts to 63%, which were positive for myeloperoxidase, CD13, CD33, CD56, and CD34. Surprisingly, t(8;21)(q22;q22.1), RUNX1‐RUNX1T1 (not DEK‐NUP214) gene, detected full...
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: Extracellular vesicles (EVs), mainly exosomes, play a role in cell-cell communication by carrying lipids, proteins, small RNAs possibly DNA between cells. Recently, it has been reported that EVs are involved MM-related processes including angiogenesis, osteolysis, immunosuppression drug resistance. Moreover, there several reports on the emerging of as new therapeutic agents for treatment MM,...