A5065227220- Advanced biosensing and bioanalysis techniques
- Protein Structure and Dynamics
- DNA and Nucleic Acid Chemistry
- Plant Gene Expression Analysis
- Chemical Synthesis and Analysis
- Cellular transport and secretion
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Phytochemicals and Antioxidant Activities
- Fermentation and Sensory Analysis
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
Institut Européen de Chimie et Biologie
2016-2019
Université de Bordeaux
2016-2019
Institut Polytechnique de Bordeaux
2016-2019
Centre National de la Recherche Scientifique
1984-2019
Chimie et Biologie des Membranes et des Nanoobjects
2007-2017
Institut Pasteur
1984
Abstract The development of large synthetic ligands could be useful to target the sizeable surface areas involved in protein–protein interactions. Herein, we present long helical aromatic oligoamide foldamers bearing proteinogenic side chains that cover up 450 Å 2 human carbonic anhydrase II (HCA) surface. are composed aminoquinolinecarboxylic acids and more flexible aminomethyl‐pyridinecarboxylic enhance helix handedness dynamics. Crystal structures HCA‐foldamer complexes were obtained with...
Abstract The helical structures of d(C-G-m5C-G-C-G) were studied in aqueous solution at various salt concentrations and temperatures by CD 1H-NMR spectroscopy. At room temperature only the B form is observed 0.1 M NaCl whereas Z forms are simultaneously present 1.8 NaCl. high concentration (4 NaCl) largely predominant (> 95%). proton resonances assigned using polarisation transfer method (between proton-proton decoupling (at concentration). Z-B-Coil transitions as a function with solution....
Abstract Quinoline‐based oligoamide foldamers have been identified as a potent class of ligands for G‐quadruplex DNA. Their helical structure is thought to target loops or grooves and not G‐tetrads. We report co‐crystal the antiparallel hairpin dimeric DNA (G 4 T G ) 2 with tetramer 1 —a helically folded oligo‐quinolinecarboxamide bearing cationic side chains—that consistent this hypothesis. Multivalent foldamer–DNA interactions that modify packing in solid state are observed.
Phosphoinositide lipids recruit proteins to the plasma membrane involved in regulation of cytoskeleton organization and signalling pathways that control cell polarity growth. Among those, Rgd1p is a yeast GTPase-activating protein (GAP) specific for Rho3p Rho4p GTPases, which actin polymerization stress pathways. Phosphoinositides not only bind Rgd1p, but also stimulate its GAP activity on membrane-anchored form Rho4p. Both F-BAR (F-BAR FCH, BAR) RhoGAP domains are lipid interactions. In...