A5022238974- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Hematopoietic Stem Cell Transplantation
- Viral Infectious Diseases and Gene Expression in Insects
- Viral-associated cancers and disorders
- Phagocytosis and Immune Regulation
- S100 Proteins and Annexins
- Cellular Mechanics and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nanowire Synthesis and Applications
- Immune Response and Inflammation
- Platelet Disorders and Treatments
- Parvovirus B19 Infection Studies
- 14-3-3 protein interactions
- Cytomegalovirus and herpesvirus research
Finnish Red Cross
2022-2024
All India Institute of Medical Sciences
2024
Lassila & Tikanoja (Finland)
2023
University of Helsinki
2011-2019
Adhesion is pivotal for most leukocyte functions, and the β(2) integrin family of adhesion molecules plays a central role. The integrins need activation to become functional, but molecular events resulting in have remained incompletely understood. In human T cells, through TCR results specific phosphorylation T758 on chain LFA-1. We now show that this leads downstream binding 14-3-3 proteins, followed by engagement guanine nucleotide exchange factor protein Tiam1 Rac1 activation....
Background: T cells that are genetically modified with chimeric antigen receptor (CAR) hold promise for immunotherapy of cancer. Currently, there intense efforts to improve the safety and efficacy CAR cell therapies against liquid solid tumors. Earlier we designed a novel backbone (FiCAR) where spacer is derived from immunoglobulin (Ig) -like domains signal-regulatory protein alpha (SIRPα). However, analysis using primary slow laborious. Methods: To explore versatility backbone, set variant...
The integrin leukocyte function–associated antigen-1 (LFA-1) plays a pivotal role in adhesion and migration, but the mechanism(s) by which this is regulated has remained incompletely understood. LFA-1 activity requires phosphorylation of its β2-chain interactions cytoplasmic tail with various cellular proteins. α-chain constitutively phosphorylated necessary for adhesion, how regulates enigmatic. We now show that substitution site (S1140A) T cells inhibits functionally important Thr-758...
Natural killer (NK) cells are a promising allogeneic immunotherapy option due to their natural ability kill tumor cells, and apparent safety. This study describes the development of GMP-compliant manufacturing protocol for local production functionally potent NK tailored high-risk acute myeloid leukemia (AML) neuroblastoma (NBL) patients. Moreover, quality control strategy considerations product batch specifications in early clinical described. The is based on CliniMACS Prodigy platform...
Background: T cells equipped with chimeric antigen receptors (CAR) have shown remarkable efficacy in targeting B lineage malignancies. Improvement of the CAR structure is needed, however, a view to developing flexibly modifiable spacers that are inert interactions unwanted cells. Specifically, binding carrying for IgG’s crystallizable fragment (FcR), recognize IgG-derived domains CARs be avoided. Methods: Two novel CD19 where IgG1-CH2 and -CH3 were replaced Ig-like from signal-regulatory...
Abstract Natural killer (NK) cells recognize malignant via their cell surface receptors and may kill them. Killer immunoglobulin-like (KIR) genotypes of donors have been reported to adjust the risk relapse after allogeneic stem transplantation (HSCT), particularly in patients with acute myeloid leukemia. To test whether non-KIR NK a similar effect, we screened 796 genetic polymorphisms 14 receptor genes for associations graft-versus-host disease (GVHD) HSCT 1,491 (from Finland, UK, Spain,...
Abstract Natural killer (NK) cells have great potential as allogeneic immune cell therapy due to their natural ability recognize and kill tumor cells, apparent safety. This study describes the development of an immunotherapy option tailored for high-risk acute myeloid leukemia (AML) in adults neuroblastoma children. A GMP-compliant manufacturing protocol local production functionally potent NK is detailed study, including a comprehensive description quality control strategy considerations...
Abstract Natural killer (NK) cells recognize and may kill malignant via their cell surface receptors. Killer immunoglobulin-like receptor (KIR) genotypes of donors have been reported to adjust the risk relapse after allogeneic stem transplantation (HSCT), particularly in patients with acute myeloid leukemia. To test whether non-KIR NK receptors a similar effect, we screened 1,638 genetic polymorphisms 21 genes for associations graft-versus-host disease (GVHD) HSCT 1,491 (from Finland, UK,...
National Human Immunodeficiency Virus (HIV) testing programs utilize antibody-based tests for confirming HIV diagnosis which has a diagnostic window period of 23-90 days. In Fiebig acute Stage I-II, an individual antibody-negative but RNA-positive test results. Here, we present case 54-year-old complete remission myeloid leukemia patient, who was recently reported negative by used in programs. However, when his sample further analyzed more sophisticated tests, there the presence early...