A5018565616- Liver physiology and pathology
- Pluripotent Stem Cells Research
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Silymarin and Mushroom Poisoning
- Cardiac Fibrosis and Remodeling
- Poisoning and overdose treatments
- Signaling Pathways in Disease
- Mast cells and histamine
- Cardiomyopathy and Myosin Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vasculitis and related conditions
- Cardiovascular Function and Risk Factors
- Renal and related cancers
- TGF-β signaling in diseases
- Adipose Tissue and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Animal Genetics and Reproduction
- Renin-Angiotensin System Studies
- Cardiac Structural Anomalies and Repair
- Hepatocellular Carcinoma Treatment and Prognosis
- Reproductive Biology and Fertility
- Orthopaedic implants and arthroplasty
Taichung Veterans General Hospital
2004-2023
National Chung Hsing University
2012-2016
National Yang Ming Chiao Tung University
2012
Non-alcoholic steatohepatitis (NASH) is associated with hepatic fibrogenesis. Despite well-known cholesterol-lowering action of statins, their mechanisms against NASH-mediated fibrogenesis remain unclear. This study aimed at investigating the in vitro and vivo anti-fibrotic properties fluvastatin (Flu). Palmitate (PA)-induced changes intracellular hydrogen peroxide levels primary rat hepatocytes (PRHs) human hepatoma cell line (HepG2) were quantified by dichlorofluorescein diacetate (DCF-DA)...
The protective effect of combination therapy with valsartan and aliskiren against renal fibrosis remains to be defined. This study was undertaken examine the effects induced by unilateral ureteral obstruction (UUO). Combination (15 mg·kg(-1)·day(-1)) (10 mg·kg(-1)·day(-1)), monotherapy (30 (20 all significantly ameliorated increase in blood urea nitrogen degree hydronephrosis determined weight length obstructed kidney. dose titration pressure measurement confirmed that provided a greater...
The purposes of this study were to examine technical details in deriving and maintaining rabbit embryonic stem (rES) cell lines analyze their characteristics. When STO cells used as feeder cells, no rES established using either intact blastocysts or inner masses (ICMs). On the mouse fibroblasts (MEF) feeder, efficiently (24%) derived. Addition leukemia inhibitory factor (LIF) cultured on MEF feeders further increased derivation efficiency (57%) cells. fact that LIF induced...
Acetaminophen (APAP) overdose causes severe liver and kidney damage. APAP-induced injury (AILI) represents the most frequent cause of drug-induced failure. APAP is relatively insoluble can only be taken orally; however, its prodrug, propacetamol, water soluble usually injected directly. In this study, we examined time-dependent effects AILI after propacetamol injection in mice. After analyses alanine aminotransferase aspartate activities histopathology, demonstrated that a novel mouse model...
Abstract Activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrogenesis. armepavine (Arm, C 19 H 23 O 3 N), an active compound from Nelumbo nucifera , has been shown to exert immunosuppressive effects on T lymphocytes and lupus nephritic mice. The aim this study was investigate whether Arm could anti-hepatic fibrogenic vitro vivo . A cell line rat HSCs (HSC-T6) stimulated with tumor necrosis factor-α (TNF-α) or lipopolysaccharide (LPS) evaluate the inhibitory Arm. An...
We investigated the individual and combined effects of leukemia inhibitory factor (LIF) basic fibroblast growth 2 (bFGF2) on derivation maintenance rabbit embryonic stem cell lines isolated from parthenogenetic activated embryos (p-rES). First, we demonstrated that p-rES can be prevented differentiation via LIF (STAT3) bFGF2 (MEK-ERK1/2 PI3K-AKT) signaling MEF feeders. High levels ERK1/2 AKT activities were crucial for maintaining cells in an undifferentiated state. Although under influence...
Background: This study aimed to investigate the relationship between oxidized regenerated cellulose (ORC) and mucosa healing in an experimental animal model. Methods: Fifteen adult Sprague-Dawley rats were randomly divided into three groups that underwent different wound treatments. In Group 1, no pharyngeal was created. 2, sutured with Prolene only. 3, Prolene, covered one layer of ORC before closure skin wound. The animals euthanized either 5 or 10 days after operation, conditions...
Effects of leukemia inhibitory factor (LIF) and fibroblast growth 2 (FGF2) on establishment maintenance rabbit embryonic stem cell (rESC) lines were assessed. When grown MEF feeders, rESC derived from fertilized embryos established maintained in medium containing paracrine factors LIF (via STAT3) and/or FGF2 MEK-ERK1/2 PI3K-AKT). However, high levels ERK1/2 AKT activities rESCs crucial for maintaining their undifferentiated proliferation. Although under the influence either (500, 1,000,...
The purpose of this study was to investigate the effects 50% red beans ethanol natto extracts fermented by Bacillus subtilis on hyperlipidemia in hamsters. Forty male hamsters were randomly assigned normal control, high-fat and with RBNE (red extracts) (200 1000 mg/kg BW) groups. treatment for 8 weeks significantly decreased body visceral fat weight Compared diet group, plasma total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein (LDL-C), high-density (HDL-C) oxidized LDL...
Background: Intravenous norepinephrine (NE) at a dose of 1-6 μg/kg/minute can induce increased extracellular matrix (ECM) and hypertrophic cardiomyopathy. This study aimed to investigate the effects higher NE on cardiac remodeling. Methods: After intraperitoneal urethane-chloralose anesthesia, 7 cats (3.03 ± 0.58 kg) received intravenous infusion 30 (ig/kg/minute for 3 hours. Aortic blood pressure heart rate (HR) were measured by polygraphy 0, 5,15, 30, 60, 90, 120, 180 minutes. Left...