A5028737721- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Schizophrenia research and treatment
- Dementia and Cognitive Impairment Research
- Social and Educational Sciences
- Blood Pressure and Hypertension Studies
- Pharmaceutical studies and practices
- Intensive Care Unit Cognitive Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Hypoxia, and Metabolism
- Pharmacy and Medical Practices
- Heart Failure Treatment and Management
- Patient Satisfaction in Healthcare
- Animal Behavior and Welfare Studies
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Healthcare professionals’ stress and burnout
- Interprofessional Education and Collaboration
- Pain Management and Opioid Use
- Lipid metabolism and disorders
- Developmental Biology and Gene Regulation
- Geriatric Care and Nursing Homes
Umeå University
2016-2025
Uppsala University Hospital
2015
Karolinska Institutet
1988-2008
Rockefeller University
2008
Sahlgrenska University Hospital
2007
Vanderbilt University Medical Center
2007
Washington University in St. Louis
2007
University of Gothenburg
2001-2006
Nobel Foundation
2006
Gladstone Institutes
2004
Tumor hypoxia is linked to increased metastatic potential, but the molecular mechanisms coupling metastasis are poorly understood. Here, we show that Notch signaling required convert hypoxic stimulus into epithelial-mesenchymal transition (EMT), motility, and invasiveness. Inhibition of abrogated hypoxia-induced EMT invasion, and, conversely, an activated form could substitute for induce these processes. deploys two distinct act in synergy control expression Snail-1, a critical regulator...
Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1alpha (HIF-1alpha) becomes stabilized and directly activates transcription of downstream genes. In addition this "canonical" certain aspects the pathway require integration with Notch signaling, i.e., HIF-1alpha can interact intracellular domain (ICD) augment response. work, we demonstrate an additional level complexity in cross-talk: factor-inhibiting HIF-1 (FIH-1) regulates not only HIF activity, but also...
The aim of this study was to investigate the molecular mechanism for changes in proteoglycan binding and LDL receptor affinity on two compositional that have been associated with atherosclerosis: cholesterol enrichment core modification by secretory group IIA phospholipase A2 (sPLA2) surface.Transgenic mice expressing recombinant apolipoprotein (apo) B sPLA2 were generated. Recombinant isolated tested their receptor-binding activity. results show site A (residues 3148-3158) apoB100 becomes...
Drug-related problems, including medication errors and adverse drug events, are common among old people. Due to, for example, greater susceptibility to side effects, people with dementia even more at risk of drug-related problems. The objectives this study were assess the occurrence character problems found or cognitive impairment. Data from a randomized controlled clinical trial exploring effects pharmacist intervention as part hospital ward team in patients 65 years older impairment used....
Increased numbers of drugs and changes in pharmacokinetic pharmacodynamic parameters among elderly people contribute to increased prevalence adverse drug reactions. Drug–drug interactions (DDIs) are an important reason for admission hospital with dementia particularly vulnerable. The aims the present study were assess occurrence characteristics clinically relevant DDIs investigate potential risk factors associated dementia. People ≥ 65 years dementia, admitted two hospitals Northern Sweden,...
A long-term follow up of 136 patients operated on for sex reassignment was done to evaluate the surgical outcome. Social and psychological adjustments were also investigated by a questionnaire in 90 these patients. Optimal results operation are essential successful Personal social instability before operation, unsuitable body build, age over 30 years at correlated with unsatisfactory results. Adequate family support is important postoperative functioning. Sex had no influence person's ability work.
Direct binding of apolipoprotein (apo)B-containing lipoproteins to proteoglycans is the initiating event in atherosclerosis, but processes involved at later stages development are unclear. Here, we investigated importance apoB-proteoglycan interaction atherosclerosis over time and role lipoprotein lipase (LPL) facilitate low-density (LDL) retention development. Atherosclerosis was analyzed apoB transgenic mice expressing LDL with normal (control LDL) or reduced proteoglycan-binding...
Antipsychotic drugs are widely used for the treatment of Behavioral and Psychological Symptoms Dementia (BPSD), despite their limited efficacy concerns about safety. The aim this study was to describe antipsychotic drug therapy among people with dementia living in specialized care units northern Sweden. This conducted 40 Sweden, a total population 344 dementia. described regard use, ADL function, cognitive function BPSD, using Multi-Dimensional Assessment Scale (MDDAS). These data were...
Polypharmacy and increased sensitivity to side effects cause adverse drug events, drug-drug interactions medication errors in the elderly.The objective of this study was investigate prevalence type drug-related problems associated factors among patients admitted a clinical pharmacist service-naïve medical ward an inland hospital northern Sweden.During September-November 2015 February-April 2016, pharmacists working as part team on conducted 103 reviews. Drug-related were identified...
To assess whether comprehensive medication reviews conducted by clinical pharmacists as part of a healthcare team reduce drug-related hospital readmission rates among people with dementia or cognitive impairment. This randomized controlled trial was carried out between January 9, 2012, and December 2, 2014. Patients aged ≥65 years impairment admitted to three wards at two hospitals located in Northern Sweden were included. Of the 473 deemed eligible for participation, 230 intervention...
The peroxisome proliferator-activated receptor (PPAR) α agonist WY 14,643 increased the secretion of apolipoprotein (apo) B-100, but not that apoB-48, and decreased triglyceride biosynthesis from primary rat hepatocytes. These effects resulted in apoB-100-very low density lipoprotein (VLDL) an apoB-100 on lipoproteins/intermediate lipoproteins. ApoB-48-VLDL was also replaced by more dense particles. proteasomal inhibitor lactacystin did influence recovery or apoB-48 hepatocytes, indicating...
All virulent group A streptococcal isolates bind fibrinogen, a property that is closely linked to expression of type‐specific antiphagocytic surface molecules designated M proteins. Here we show although the proteins from two different strains, M1 and M5, both fibrinogen with high affinity, they interact regions in ligand. Moreover, mapping experiments demonstrated fibrinogen‐binding M5 are quite dissimilar at amino acid sequence level plasma protein. In spite these differences, could be...
ABSTRACT Background: Behavioral and psychological symptoms are common among cognitively impaired individuals psychotropic drugs widely used for their treatment. The aim of this study was to describe the prevalence associated factors anti-dementia drug use old people with cognitive impairment living in geriatric care settings. Methods: comprised 2,019 units county Västerbotten, Sweden. Data concerning use, function activities daily living, function, behavioral were collected, using...
Medication-related problems (MRPs) are common during transitions of care and can lead to hospital readmissions. This patient safety issue is especially pronounced among geriatric patients. In a randomised controlled trial (RCT), the effect pharmacist-led follow-up programme after discharge from for people ≥75 years in north Sweden was investigated. One components telephone calls study participants, find manage MRPs. To explore participants' views on by clinical pharmacist RCT....
Thyroid hormone induces differentiation of many different tissues in mammals, birds, and amphibians. The all differentiate from proliferating precursor cells, the normal cell cycle is suspended while cells undergo differentiation. We have investigated how thyroid affects expression E2F-1 protein, a key transcription factor that controls G1- to S-phase transition. show during hormone-induced embryonic carcinoma oligodendrocyte levels mRNA protein decrease. This caused by receptor (TR)...
Psychotropic drugs are widely used among old people with dementia but few studies have described long-term treatment in this group of patients. The purpose study was to explore the use psychotropic dementia. Data on drug use, functioning activities daily living (ADL), cognitive function and behavioral psychological symptoms were collected at baseline six months later, using Multi-Dimensional Dementia Assessment Scale (MDDAS). data 2005–2006. Detailed about prescribing from prescription...