A5062406870- Cancer, Hypoxia, and Metabolism
- Pharmaceutical Practices and Patient Outcomes
- Geriatric Care and Nursing Homes
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- High Altitude and Hypoxia
- Intergenerational Family Dynamics and Caregiving
- Nutrition and Health in Aging
- Neurological diseases and metabolism
- Hereditary Neurological Disorders
- Ubiquitin and proteasome pathways
- Dementia and Cognitive Impairment Research
- Neurogenetic and Muscular Disorders Research
- Cardiovascular and exercise physiology
- Physical Activity and Health
- Chronic Disease Management Strategies
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Intensive Care Unit Cognitive Disorders
- ATP Synthase and ATPases Research
- Healthcare cost, quality, practices
University of South Australia
2020-2025
Flinders University
2018-2025
Macquarie University
2024
The University of Sydney
2018
Australian Research Council
2008-2009
Centre National de la Recherche Scientifique
2004-2008
The University of Adelaide
2003-2008
Centre Antoine Lacassagne
2004-2008
Ambedkar University Delhi
2006
Boston Children's Hospital
1999
Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1alpha (HIF-1alpha) becomes stabilized and directly activates transcription of downstream genes. In addition this "canonical" certain aspects the pathway require integration with Notch signaling, i.e., HIF-1alpha can interact intracellular domain (ICD) augment response. work, we demonstrate an additional level complexity in cross-talk: factor-inhibiting HIF-1 (FIH-1) regulates not only HIF activity, but also...
Abstract Background This study estimated the prevalence of evidence-based care received by a population-based sample Australian residents in long-term (LTC) aged ≥ 65 years 2021, measured adherence to clinical practice guideline (CPG) recommendations. Methods Sixteen conditions/processes amendable estimating at population level were identified from data and CPGs. Candidate recommendations ( n = 5609) extracted 139 CPGs which converted indicators. National experts each condition rated...
The hypoxia-inducible factor (HIF) is a key player in transcriptional pathway that controls the hypoxic response of mammalian cells. Post-translational modification alpha subunit HIF determines its half-life and activity. Among multiple reported modifications, acetylation, by an acetyltransferase termed arrest-defective-1 protein (ARD1), has been to decrease HIF-1alpha stability therefore impact on gene expression. In contrast, we report both overexpression silencing ARD1 had no or -2alpha...
To assess the effectiveness of a pharmacist-led intervention using validated tools to reduce medicine-induced deterioration and adverse reactions.Multicenter, open-label parallel randomised controlled trial involving 39 Australian aged-care facilities.Residents on ≥4 medicines or ≥1 anticholinergic sedative medicine.Pharmacist-led detect signs symptoms which occurred every 8 weeks over 12 months.Usual care (Residential Medication Management Review) provided by accredited pharmacists.Primary...
Objectives This analysis estimates the whole‐of‐system direct costs for people living with dementia in residential care by using a broad health and social provision perspective compares it to without care. Methods Data were collected from 541 individuals permanently 17 facilities across Australia. The annual cost of was determined individual resource use data reported status individuals. Results average approximately AU$88 000 (US$ 67 100) per person 2016. constituted 93% total costs....
Abstract Accumulation of HIF‐1α during normoxic conditions at high cell density has previously been shown to occur and can be used stabilize protein in the absence a specific anaerobic chamber. However, impact origin this pool HIF‐1α, obtained under normoxia, underestimated. In study, we have systematically compared related pools stabilized normoxia by those low hypoxia. At first glance, these two stimuli appear similar outcomes: stabilization induction HIF‐1‐dependent genes. upon careful...
Abstract The adoption of technology, particularly for monitoring the effects medications in residential aged care (nursing home), has been slow. Ageing populations have led to increased demand globally, resulting a growing imperative implement technological solutions meet complex healthcare and medication needs older people care. This commentary explores potential challenges associated with implementing interventions within improve effects. Drawing on insights from two implementation trials,...
Studies have shown that use of medicines with sedative or anticholinergic properties is associated a decline in physical function; however, the effects not been quantified, and it known how which specific movements are affected. This prospective study quantified impact change load over time on 24-hour activity composition.This used data collected from randomised trial assessing an ongoing pharmacist service residential aged care. The composition sleep, sedentary behaviour, light-intensity...
Introduction Many medicines have adverse effects which are difficult to detect and frequently go unrecognised. Pharmacist monitoring of changes in signs symptoms these effects, we describe as medicine-induced deterioration, may reduce the risk developing frailty. The aim this trial is determine effectiveness a 12-month pharmacist service compared with usual care reducing frailty reactions older people living aged-care facilities Australia. Methods analysis deterioration multicentre,...
Residents of aged-care facilities have high rates adverse drug events. This study aimed to identify risk factors for events in residents. was a secondary using data from multicentre randomised controlled trial. Data 224 residents whom there 6 months baseline information were analysed. We assessed the and falls (post hoc) subsequent months. Adverse identified via key word search resident care record adjudicated by multidisciplinary panel modified version Naranjo criteria. Covariates through...
Aged care residents are vulnerable to the harmful effects of medicines; however, data on prevalence and preventability adverse medicine events in aged scarce. To determine Australian residents. A secondary analysis from Reducing Medicine-Induced Deterioration Adverse Reactions (ReMInDAR) trial was conducted. Potential were identified independently screened by two research pharmacists produce a short-list potential events. An expert clinical panel reviewed each likelihood that event related...
Medicine-related problems are common in older people living residential aged care facilities (RACFs). Recognising the significant medicine-related problems, Australian government has announced a $345 million funding package to employ on-site pharmacists RACFs starting 2023. The new provide range of clinical services reduce adverse events, promote quality use medicines, and improve governance education. Underpinning these services, authors argue that play critical role as resident advocates....
Abstract Purpose This study analysed data from a national survey of people living in Australian Residential Aged Care Facilities (RACFs) reporting on what is the best thing about where they live and suggestions for improvement. Data prior to Covid-19 pandemic were compared with during pandemic. Methods Qualitative Happy Life Index Survey using summative content analysis code responses sets then organise them into categories. Once categorised, pre-Covid-19 mid-Covid-19 descriptive statistics....
Large population-based studies examining frailty trajectory found a linear increase in over time. The pattern which changes time for an individual person is less well-described. We examined the of older adults living aged-care Australia.This secondary study used data from randomised controlled trial involving 39 facilities Australia. intervention was on-going pharmacist-led occurring every 8 weeks 12 months aimed at preventing medicine-induced deterioration and adverse reactions. Frailty...
Abstract Introduction Frailty is increasingly recognised as a dynamic syndrome, with multiple causes, dimensions and consequences. There little understanding of how those frailty assessment metrics interact over time. The aim this study was to describe the longitudinal correlation between five metrics, namely multimorbidity, muscular strength, mood alterations, cognitive capacity, functional capacity in cohort aged care (nursing home) residents. Methods 248 residents Index at baseline <...
PAGE 31133: In the right column, lines 8–11 under “Materials and Methods, Semiquantitative RT-PCR,” sentence “Two independent sets of primers were used to amplify ARD1: set 1 forward primer 5′-AAG CTT GCC ATG GAC TAC AAG-3′ reverse 5′-TGT TGG TAT GGC TGA TTA TCA-3′” should be changed read 5′-ATT TGT GAA GCG TTC CC-3′ 5′-CCT CAT CTG TGC TCT TGG-3′.”
Abstract Purpose Residents living in residential aged care facilities (RACF) are a vulnerable sector of the community during Covid-19 pandemic, both from disease and resultant control measures, such as lockdowns, quarantines, social distancing. In patient centred health system, it is important that views residents their relatives, ie. ‘consumers’, included to help understand effect these measures. The Happy Life Index (HLI) consumer completed survey tool measures modifiable quality life...