A5018656492- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Cancer survivorship and care
- Brain Metastases and Treatment
- Advanced Breast Cancer Therapies
- Microscopic Colitis
- Healthcare Policy and Management
- Otitis Media and Relapsing Polychondritis
- Infective Endocarditis Diagnosis and Management
- Global Cancer Incidence and Screening
- Emergency and Acute Care Studies
- Colorectal Cancer Treatments and Studies
- Systemic Lupus Erythematosus Research
- Prostate Cancer Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Sexual Differentiation and Disorders
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Streptococcal Infections and Treatments
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Stuttering Research and Treatment
- Data-Driven Disease Surveillance
- Chemotherapy-induced cardiotoxicity and mitigation
- Management of metastatic bone disease
University of Pennsylvania
2024-2025
St Bartholomew's Hospital
2023
Dana-Farber Cancer Institute
2023
King's College London
2022
Navitas Systems (United States)
2022
Civita
2022
Guy's and St Thomas' NHS Foundation Trust
2021
Royal Perth Hospital
1958-2020
Princess Margaret Hospital for Children
2020
Guy's Hospital
2020
Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically with corticosteroids, and infliximab (IFX) used in corticosteroid-refractory cases. However, robust outcome data these patients are scarce. We conducted a multicenter (six cancer centers), cohort study of outcomes IFX between 2007 2020. The primary was corticosteroid-free clinical...
This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection receptor ( AR ) gene alterations within the body and/or enhancer region.
The case of a man aged 62 years with bilateral mammary metastases from prostatic carcinoma is presented. importance histological features in differentiating this lesion primary emphasized. ætiological implications such differentiation are discussed.
Maternal obesity is a growing health concern that has previously been associated with increased need for induction of labour (IOL) and caesarean section (CS) rates. Currently, limited evidence explores the influence maternal body mass index (BMI) on Bishop Score (BS) outcome IOL. This study hypothesises will lead to lower BS at presentation, higher rates failed IOL, CS rates.To explore likelihood IOL.A retrospective cohort analysis was conducted all live, term, singleton, cephalic deliveries...
Objective To evaluate the implementation of a novel algorithm‐based discharge programme for community follow‐up men with prostate cancer. Patients and Methods Men cancer considered suitable were identified from consultant‐led clinical nurse‐specialist telephone clinics at Nottingham University Hospitals National Health Service Trust. discharged on to one four pathways: watchful waiting, androgen‐deprivation therapy ( ADT ), post‐prostatectomy, post‐radiotherapy. Primary care providers asked...
Introduction: CTP has increasingly been incorporated into the evaluation of all patients with suspected acute ischemic stroke (AIS), including those minor symptoms. We aimed to assess incremental value in treatment decision-making among low NIHSS. Methods: performed a retrospective cohort study who underwent upon presentation ED at three academic, urban hospitals Philadelphia, PA between January 1, 2022 and December 31, 2022. collected data on initial NIHSS score, AIS decisions, subsequent...
Malignant meningitis is a rare condition with varied clinical presentations, often mimicking other neurological conditions. Here we report case of malignant from primary bronchogenic melanoma. The patient initially presented vomiting and headache. Over the next 12 days she developed rapidly progressive neurology: losing mental faculties, vision, hearing limb power. Lumbar puncture results revealed cells. Computer tomography chest found an endobronchial lesion which was later biopsied...
Background: Development of modern therapeutic approaches over the last decade has improved short-term well-being in JIA patients. This study examines disease damage and body composition (BC). Aims: Comparison patients’ clinical with matched controls assessing BC, cross-sectional inflammatory markers levels joint uveitis-associated relating to their management. Methods: 112 patients (disease duration ≥5 years) were cross-sectionally compared 127 age, sex, ethnicity deprivation score-matched...
e17003 Background: Low levels of serum testosterone are associated with higher all-cause mortality and cardiovascular in some studies.(PMID: 18040028). But men low at reduced risk developing prostate cancer. (PMID: 30077399). In middle-aged elderly men, single point measurements have been shown to reliably reflect long term androgen exposure. [PMID: 1548361]. We assessed the interaction pre-treatment newly diagnosed Methods: Prostate cancer pts enrolled an ethics approved, prospective study...
12091 Background: We prospectively assessed whether Psychological factors such as anxiety and depression can have a detrimental effect on long term overall survival of prostate cancer patients (pts). Methods: Prostate pts participating in an ethics Committee approved, Prospective study evaluating Andropause rating scale. All had radical radiotherapy with androgen deprivation therapy. Pts completed baseline HADS questionnaire before any treatment was initiated & at 3mths after completion...
Background: Development of modern therapeutic approaches over the last decade has improved short-term well-being in JIA patients. This study examines disease damage and body composition (BC). Aims: Comparison patients’ clinical with matched controls assessing BC, cross-sectional inflammatory markers levels joint uveitis-associated relating to their management. Methods: 112 patients (disease duration ≥5 years) were cross-sectionally compared 127 age, sex, ethnicity deprivation score-matched...
63 Background: Androgen deprivation therapy (ADT) plays an important role in the management of non-metastatic prostate cancer (NMPC). We prospectively assessed performance a symptom rating scale, aging men’s symptoms score (AMS) relation to other validated QOL tools. Methods: Following ethics approval, 145 patients with diagnosis NMPC receiving ADT as part radical treatment were enrolled after informed consent. Data was collected using EORTC QLQ-C30, AMS and International Index Erectile...
<h3>Introduction</h3> National Institute of Clinical Excellence guidelines recommend considering a cancer pathway referral for suspected lower gastrointestinal cancers via Lower Gastrointestinal two week wait (LGI 2WW). Unexplained weight loss, abdominal pain, rectal bleeding, unexplained iron deficiency anaemia and change in bowel habit are but few indications. A third cases England diagnosed this route. In the majority, referred on LGI 2WW, is not final diagnosis. United Kingdom led by...
e23087 Background: The evidence for effect of anxiety and depression on cancer survival rates is contradictory (Ref : Prostate-JCO 2014.32:2471, Breast-JCO 1987. 5:768, Lung-JPSM 2017.53:1057). We assessed the prospectively collected HADS score (Hospital Anxiety Depression Scale) subsequent long term survival. Methods: After ethics approval & informed consent, 145 prostate patients (pts) were enrolled, onto a QOL study. questionnaire was completed at baseline 3 mths after start androgen...
Abstract Introduction: Dual HER2 targeting improved pCR rates (ypT0ypN0) compared with Herceptin plus chemotherapy in the TRYPHAENA and NeoSphere registration trials. Pertuzumab-containing regimens (FEC-THP TCHP) were adopted at Kent Oncology Centre (KOC) following national funding approval December 2016. Methods: A retrospective study of 176 (stage 1-3) HER2+ breast cancer patients receiving HER2-directed NACT KOC between November 2014- 2018 was conducted. Single treatment (S) used FEC-TH....