A5029382054- Macrophage Migration Inhibitory Factor
- PI3K/AKT/mTOR signaling in cancer
- Cancer Diagnosis and Treatment
- Connective tissue disorders research
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Hedgehog Signaling Pathway Studies
- Dental materials and restorations
- Chemical Synthesis and Analysis
- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- Antimicrobial Peptides and Activities
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Protease and Inhibitor Mechanisms
- Genomics, phytochemicals, and oxidative stress
- COVID-19 and healthcare impacts
- Pregnancy-related medical research
- Cytokine Signaling Pathways and Interactions
- Lipoproteins and Cardiovascular Health
St. Jude Children's Research Hospital
2025
University of Dundee
2010-2024
Dundee Dental Hospital
2008-2023
PDS Biotechnology (United States)
2023
Oroville Hospital
2021-2022
Clatterbridge Cancer Centre NHS Foundation Trust
2016-2018
The George Institute for Global Health
2015
Technische Universität Dresden
2015
James Cook University Hospital
2005-2015
Ospedale Sacro Cuore Don Calabria
2015
The objective of this experiment was to determine the dose response dexamethasone (DEX) on C2C12 myogenic cells and examine effects anabolic compounds estradiol (E), testosterone (T), dihydrotestosterone (D) alone in combination with DEX proliferation protein turnover cultured cells. In first study, were treated seven concentrations (0, 25, 50, 75, 100, 150, or 200 nM) medium without 5% horse serum (HS) for determination synthesis degradation, six 200, 250 fetal bovine cell measurements....
Mutations in the Candidozyma ( Candida ) auris β-glucan synthase gene FKS1 altering S639 are frequently associated with clinical echinocandin resistance. However, direct impact of these mutations remains uncharacterized. We have developed a novel C. auris- optimized E pisomal P lasmid- I nduced C as9 (EPIC) gene-editing system capable recyclable precision genome editing and demonstrate contribution S639F mutation to The EPIC was generated for use , ADE2 modification evaluated 5 clades....
This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection receptor ( AR ) gene alterations within the body and/or enhancer region.
First identified in 2009, Candidozyma auris (formerly Candida ) is an emerging multidrug resistant fungus that can cause invasive infections with a crude mortality rate ranging from 30-60%. Currently, 30-50% of C. isolates are intrinsically to amphotericin B. In this work, we characterized clinical case acquired B resistance using whole genome sequencing, large-scale phenotypic screen, comprehensive sterol profiling, and genotypic reversion CRISPR. Data obtained work provides evidence...
Abstract The Signal Transducer and Activator of Transcription (STAT) proteins comprise a family latent transcription factors with diverse functions. STAT3 has well established roles in cell proliferation, growth survival, its persistent activation been detected high frequency many human cancers. As constitutive appears to be vital for the continued survival these cancerous cells, it emerged as an attractive target chemotherapeutics. We examined whether inhibitory activities bioactive...
Development of the lip and palate involves a complex series events that requires close co-ordination cell migration, growth, differentiation apoptosis. Palatal shelf elevation is considered to be driven by regional accumulation hydration glycosoaminoglycans, principally hyaluronan (HA), which provides an intrinsic force, directed components extracellular matrix (ECM). During embryogenesis, pericellular surrounding migrating proliferating cells rich in HA. This would suggest HA may important...
Migration stimulating factor (MSF) is a truncated oncofetal fibronectin isoform expressed by fetal and tumor-associated cells. MSF mRNA distinguished from other isoforms its size (2.1 kb) the inclusion of specific intronic sequence at 3' end. Initial Northern blot analysis with MSF-specific probe indicated presence this 2.1-kb transcript an additional unexpected 5.9-kb RNA present in both MSF-secreting (fetal) nonsecreting (adult) fibroblasts. Our investigations into nature these transcripts...
Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk. We aimed to investigate relationship between these factors Akt phosphorylation, determine prognostic value. VEGF-positive HNSCC biopsies, status, were analyzed by immunohistochemistry (IHC) for Akt, phosphorylated at residues S473 T308. Comparisons tissues carried out using a Mann–Whitney U test. Associations variables continuous...
Summary. In order to determine the most effective regimen for prevention of infection after elective hysterectomy, 300 patients were randomly assigned receive three perioperativc doses either amoxycillin‐clavulanic acid (1.2 g intravenous) or metronidazole (1 suppository). Of 280 who assessable 138 given and 142 received metronidazole; 268 underwent abdominal hysterectomy 12 had vaginal hysterectomy. Patients in group significantly less infectious morbidity (13.8%) than those (33.1%). There...
Glucocorticoid receptor (GR) overexpression has been linked to increased tumour aggressiveness and treatment resistance. GR antagonists have shown enhance effectiveness. Emerging research investigated mifepristone, a antagonist, as an anticancer agent with limited in the context of oral cancer. This study effect mifepristone at micromolar (µM) concentrations 1, 5, 10 20 on proliferation migration cancer cells, 24 48 h. Scratch scatter assays were utilised assess cell migration, MTT used...
The signalling pathways involved in metastasis of oral adenoid cancer cells (TYS) response to cancer-associated fibroblasts (COM D24) and normal mucosal (MM1) was examined. Metastatic cell behaviour observed by cell-scatter, 3-D-collagen gel migration, 3-D-spheroid invasion assays. Akt (v-Akt murine thymoma viral oncogene), MAPK(Mitogen activated protein kinase), EGFR (Epidermal growth factor receptor), TGFβRI (Transforming beta receptor 1), CXCR4 (C-X-C chemokine 4) inhibitors were used...
ABSTRACT A single 200-mg dose of clinafloxacin was given orally to each nine healthy male volunteers, and the concentrations drug were measured in plasma, cantharidin-induced inflammatory fluid, urine over following 24 h (48 case urine). The mean maximum concentration plasma 1.34 μg/ml at a time 1.8 postdose. fluid 1.3 3.8 elimination half-life 5.65 h. overall penetration into 93.1%, as assessed by determining ratio area under concentration-time curves. Recovery 58.8% 71.8% 48