A5016224976- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Acute Myocardial Infarction Research
- Esophageal Cancer Research and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Marine animal studies overview
- Acute Ischemic Stroke Management
- Orthopaedic implants and arthroplasty
- Cardiac Imaging and Diagnostics
Utrecht University
2018-2021
University Medical Center Utrecht
2016-2021
Heidelberg University
2018-2019
University Hospital Heidelberg
2018-2019
Background: Currently, 2 third-generation transcatheter valves, 29-mm Sapien-3 and 34-mm Evolut-R (ER), are indicated for large sized aortic annuli. We analyzed short 1-year performance of these valves in patients with (area ≥575 mm or perimeter ≥85 mm) extra-large (≥683 ≥94.2 annuli undergoing valve replacement. Methods: A total 833 across 12 centers symptomatic stenosis underwent replacement (n=640) ER (n=193). Clinical, anatomic, procedural characteristics were collected, Valve Academic...
Background The timing of onset and associated predictors late new conduction disturbances (CDs) leading to permanent pacemaker implantation (PPI) following transcatheter aortic valve (TAVI) are still unknown, however, essential for an early safe discharge. This study aimed investigate the CDs in patients requiring PPI (LCP) TAVI. Methods results We performed retrospective analysis prospectively collected data from five large volume centres Europe. Post-TAVI electrocardiograms telemetry were...
Postoperative delirium (POD) is a frequently observed complication after transcatheter aortic valve replacement (TAVR). The effects of intraoperative hypotension (IOH) on POD occurrence are currently unclear.A retrospective observational cohort study patients who underwent TAVR was conducted. We predefined IOH as area under the threshold (AUT) five mean arterial blood pressures (MBP), varying from <100 to <60 mmHg. AUT consisted combination duration and depth MBP thresholds, expressed in...
Transcatheter aortic valve implantation (TAVI) is a safe and effective treatment for inoperable, intermediate- or high-risk patients with severe symptomatic stenosis has been associated excellent clinical outcomes. A clinically relevant remaining problem regurgitation (AR) post-TAVI, which increased mortality. Therefore, we conducted prospective randomised trial to assess the safety efficacy of first-generation self-expandable (SEV; CoreValve) third-generation balloon-expandable (BEV; Sapien...
Periprosthetic aortic regurgitation (PPR) after transcatheter valve implantation (TAVI) remains an important issue associated with impaired long-term outcomes. The current randomised study aims to evaluate potential differences between the balloon-expandable Edwards SAPIEN-3 and self-expanding Medtronic CoreValve system main focus on post-TAVI PPR by means of novel imaging endpoints, additional other clinical endpoints.The primary endpoint this is quantitative assessment severity...
The aim of this study was to describe the incidence, mechanisms, management and outcomes intracardiac shunts (ICS) following TAVI.This a multicentre registry across 10 centres aimed at gathering all cases ICS (1.1%) including infection-related (IRICS, 0.3%) or aseptic (AICS, 0.8%) shunts. Patients presented porcelain aorta (24% vs. 6.8%, p=0.024) had been treated with predilation (88% 68.5%, p=0.037) post-dilation (59.1% 19.3%, p<0.001) more often. Median time from intervention diagnosis...
Abstract Objectives To explore the prevalence of smoking, and its association with clinical mortality outcome among patients undergoing transcatheter aortic valve replacement (TAVR). Background Less data exist regarding effect baseline smoking status on TAVR. Methods Consecutive who underwent TAVR at two high volume Dutch centers were included. Smoking was prospectively questioned by a structured interview admission. Primary endpoint 1‐year all‐cause after Results A total 913 consecutive...
Accuracy of aortic regurgitation (AR) quantification by magnetic resonance (MR) imaging in the presence a transcatheter heart valve (THV) remains to be established. We evaluated accuracy cardiac MR velocity mapping for antegrade flow (AF) and retrograde (RF) across THV optimal slice position use imaging. In systematic fully controlled laboratory ex vivo setting, two THVs (Edwards SAPIEN XT, Medtronic CoreValve) were tested porcine model (n = 1) under steady conditions. Results showed high...
Abstract Objectives To compare the outcomes of transfemoral ACURATE neo (NEO) and Sapien 3 (S3) patients in terms device success clinical safety using a propensity score analysis. Background Differences between latest‐generation balloon‐expandable S3 self‐expanding NEO “real‐world TAVI population” are still unclear. Methods We compared up to 6 months analysis (inverse probability treatment weighting [IPTW]) account for differences baseline characteristics. Results A total 345 underwent...
of improved ViV haemodynamics and topdown deployment without pacing.However, it is non-repositionable.
Introduction A substantial proportion of patients submitted to transcatheter aortic valve replacement (TAVR) continues be affected by procedure-related neurological events, with 30-day clinical stroke rates in the range 4-7%. Also, routine neuroimaging studies reveal that ischaemic cerebral infarction caused showers emboli during instrumentation and placement affect virtually all undergoing TAVR1,2,3. In order prevent these embolic phenomena, several protection devices (CEPD) have recently...
We aimed to evaluate the effect of transcatheter aortic valve implantation (TAVI) approaches on mortality and identify modifiers predictors for mortality.Alternative access routes transfemoral (TF) TAVI include surgical intra-thoracic direct-aortic (DA) transapical (TA) approach. TA has been associated with a higher rate. hypothesized that this is related modifiers, in particular left ventricular ejection fraction (LVEF).This multicentre study derived its data from prospective registries. To...
Transcatheter aortic valve implantation (TAVI) is a well-accepted alternative treatment for intermediate or high-risk patients with symptomatic severe native stenosis. As the use of TAVI increases, there continuous growing insight into in technical possibilities procedure and parallel decrease complications. A serious but rare complication ventricular septal defect (VSD). We report case 90-year-old woman who underwent an uncomplicated procedure. She was readmitted within 2 weeks because...
We aimed to evaluate the extent of left ventricular (LV) recovery post transcatheter aortic valve implantation (TAVI) and its clinical predictors.This was a retrospective study on patients treated with TAVI from August 2008 September 2017. Patients were sub-classified according their baseline LV function as normal, mildly impaired, moderately impaired or severely impaired. Echo pre early compared assess change. Predictors change sought univariate multivariate ordinal logistic regression...
Abstract Objectives This study aimed to investigate the onset and associated predictors of new conduction disturbances (CDs) requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve (TAVI). Background The CDs leading PPI are still unknown. However, these essential for safe early discharge. Currently, lead prolonged post-procedural monitoring TAVI, limiting discharge possibilities. Methods We retrospectively analyzed data from five centers in Europe. Post-TAVI...
BackgroundLittle is known about the occurrence of unknown preexisting conduction disturbances/sinus node dysfunction (CDs/SND) in transcatheter aortic valve replacement (TAVR) patients. Preexisting CDs/SND could be a possible predictor for permanent pacemaker (PPM) implantation post-TAVR. In this pilot study, we aimed to investigate additive value pre-TAVR 24-hour Holter monitoring (HM) diagnose predicting PPM post- TAVR.MethodsThis single-center and retrospective study included 164 HM...